تجاوز إلى المحتوى الرئيسي
User Image

Iftekhar Md Hassan

Associate Professor

Associate Professor

كلية العلوم
AB-73/1', Ground Floor, Building 5, College of Sciences, Dariyah, KSU
المنشورات
مقال فى مجلة
2014

Antioxidant Bioactivity of Samsum Ant (Pachycondyla sennaarensis) Venom Protects against CCL 4-Induced Nephrotoxicity in Mice

To assess whether SAV could influence the effects of carbon tetrachloride (CCL4) exposure, mice were treated with SAV in doses of 100, 200, 300 and 400 μg/kg body weight and the effects on oxidative status and kidney function were studied. Serum levels of creatinine, malondialdehyde (MDA), and blood urea, together with renal and hepatic levels of MDA, glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) were quantified in order to evaluate antioxidant activity. Results showed that the group injected with CCL4 exhibited significantly higher levels of oxidative stress markers, MDA, and significantly lower concentrations of GSH, SOD and catalase. SAV was found to significantly improve these oxidative markers, occasionally, in a dose-dependent manner. Furthermore, treatment with SAV was associated with the same behaviour in respect to kidney functions which had previously been impaired by CCL4. Histopathological examination demonstrated that SAV, in different groups, improved the renal tissue damage induced by CCL4 and histological scores confirmed that significant improvements were obtained after treatment with SAV, particularly with the lowest dose (100 μg/kg body weight). In conclusion, SAV has the potential capability to restore oxidative stability and to improve kidney functions after CCL4 acute injury.

نوع عمل المنشور
Assistant professorship
رقم المجلد
Article ID 763061
رقم الانشاء
Article ID 763061
مجلة/صحيفة
Oxidative Medicine and Cellular Longevity
الصفحات
8 pages
مزيد من المنشورات
publications

Amyloid fibrils are highly ordered …

بواسطة Mohd Shahnawaz Khan a, ⁎, Sheraz Ahmad Bhat b , Md Tabish Rehman c , Iftekhar Hassan d , Shams Tabrez e , Mohamed F. AlAjmi c , Afzal Hussain c , Fohad Mabood Husain f , Salman Freeh Alamery g
2018
publications

The present study was designed to investigate if elevated copper level can be targeted to enhance the efficacy of a significant anticancer drug, imatinib (ITB). The antineoplastic activity of this…

بواسطة Iftekhar Hassan1, Azmat Ali Khan2, Shazia Aman3, Wajhul Qamar4,5, Hossam Ebaid1, Jameel Al-Tamimi1, Ibrahim M. Alhazza1 & Ahmed M. Rady1
2018
publications

Cells constantly adapt to external humoral cues like cytokines and hormones, but practically most cellular behavior is under locally guided control via cell-cell interactions. Galectins (Gals) are…

بواسطة Ghulam Md Ashraf, Asma Perveen, Syed Kashif Zaidi, Ausaf Ahmad, Shazi Shakil, Chelapram Kandy Firoz, Nasimudeen R. Jabir, Iftekhar Hassan, Taqi Ahmad Khan, Nagendra Sastry Yarla and Shams Tabrez.
2017