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حصه عبد الله العبدالكريم

Associate Professor

عضو هيئة تدريس

كلية العلوم
مبنى 5- الدور الثالث- مكتب 263
المنشورات
مقال فى مجلة
2022

Synthesis, structural elucidation, DFT calculation, biological studies and DNA interaction of some aryl hydrazone Cr3+, Fe3+, and Cu2+ chelates.

journal homepage: www.elsevier.com/locate/cbac

ABSTRACT
The current research focuses on the treatment of Cr(III), Fe(III) and Cu(II) metal ions with aryl hydrazone ligand
named (E)-4-(((diphenylmethylene)hydrazono)methyl)benzene-1,3-diol (DPHB) to afford four novel solid complexes with high yields. Different characterization approaches, including infrared, UV–visible, and NMR spectroscopies, elemental analyses, and thermal gravimetric analysis (TGA), revealed that all mononuclear crystalline
metal chelates with good thermal stability had a six-coordination with octahedral geometry. Density Functional
Theory (DFT) computations were used and provided a reasonable explanation for these metal chelates’ electrical
and structural features. Furthermore, investigations of electronic absorption spectroscopy, hydrodynamics, and
electrophoresis demonstrated that these new compounds interact with calf thymus deoxyribonucleic acid (CTDNA) in a variety of ways. As a result, the Kb and ΔG∕=
b values of such interactions were in the following order:
DPHBCu > DPHBCr > DPHBFe complex. Additionally, the novel metal chelates have been studied antibathogenically and found to be significantly effective compared to the comparable DPHB hydrazone ligand.
The anti-proliferative activities of the investigated compounds were also evaluated against different lines of
cancer cells and exhibited significant cytotoxic activity. In addition, observations of antioxidant activity suggest
that antioxidant activity relative to ordinary ascorbic acid was demonstrated in the molecule.

نوع عمل المنشور
بحث أصيل
اسم الناشر
ELSEVIER
مدينة النشر
UK
رقم المجلد
97
مجلة/صحيفة
Computational Biology and Chemistry
الصفحات
107643
مزيد من المنشورات
publications

The synthesis of a simple, highly tunable, and effective BSI ligand,
2-(benzothiazol-2-ylimino)-2,3-dihydro-1H-imidazol-4-ol, was presented. Three
new coordinating substances of BSI…

2023
publications

A series of new bis-hydrazone complexes was obtained from ((N’E,N’’’E)-2,2 -(1,3-phenylenebis (oxy))bis(N’-(4,5-di-tert-butyl-2-hydroxybenzylidene)acetohydrazide)) ligand (BS) with Co2+, Cu2+, Ni2…

2022
publications

abstract
Variable-temperature X-ray structural study of the complex [(Ph3P)2N]2[Pt2Ag4Cl2(C2Ph)8] prepared by
the reaction of cis-[PtCl2(AsPh3)2] and [(Ph3P)2N][Ag(C2Ph)2] in 1:2 M…

2011
تم النشر فى:
ELSEVIER