هلا عبدالرؤوف عز الدهشان

My researh interests focus on immunotherapy, molecular genetics, and genome editing, with a strong emphasis on editing primary cell lines. I possess a robust background in T-cell molecular and cellular immunology, particularly in the realm of cell and gene therapy. My work emphasizes the innovative application of advanced genome editing tools, including CRISPR/Cas9 systems and base editing techniques, to develop groundbreaking therapeutic solutions. During my PhD at University College London, I specialized in CAR-T cell therapy, specifically targeting T-cell malignancies. My project tackled critical challenges such as T-cell fratricide, employing advanced genome editing tools, including virus-free protocols with SpCas9 ribonucleoproteins, to enhance therapeutic efficacy. Future work will focus on exploring next-generation genome editing technologies to enhance the efficacy and specificity of immunotherapies. I am particularly interested in developing innovative approaches for targeted manipulation of immune cell functions to improve outcomes in resistant cancers. Additionally, I seek to investigate the role of the tumor microenvironment in shaping immune responses, with the goal of designing therapies that effectively boost anti-tumor immunity and overall therapeutic effectiveness.