Synthesis, Characterization, and Antimicrobial Studies of Novel Series of 2,4-Bis(hydrazino)-6-substituted-1,3,5-triazine and Their Schiff Base Derivatives
Hessa. H. Al-Rasheed, E. N. Sholkamy, M. Al Alshaikh, M. R. H. Siddiqui, Ahmed S. Al-Obaidi, and Ayman El-Faham, 2018
The present work represents the synthesis, characterization, and antimicrobial studies of novel series of 2,4-bis(hydrazino)-6-substituted-1,3,5-triazine and their Schiff base derivatives. IR, NMR (H-1 and C-13), elemental analysis, and LC-MS characterized the prepared compounds. The biological activity of the target products was evaluated as well. Twenty-two of the prepared compounds were selected according to their solubility in aqueous DMSO. Only eight compounds showed good activity against the selected pathogenic bacteria and did not show antagonistic effect against fungus Candida albicans. Two compounds 4k and 5g have wide-range effect presently in Gram-positive and Gram-negative bacteria while other compounds (4f, 4i, 4m, 5d, 6i, and 6h) showed specific effect against the Gram-negative or Gram-positive bacteria. The minimum inhibitory concentration (MIC, mu g/mL) of 4f, 4i, 4k, and 6h compounds against Streptococcus mutans was 62.5 mu g/mL, 100 mu g/mL, 31.25 mu g/mL, and 31.25 mu g/mL, respectively. The MIC of 4m, 4k, 5d, 5g, and 6h compounds against Staphylococcus aureus was 62.5 mu g/mL, 31.25 mu g/mL, 31.25 mu g/mL, 100 mu g/mL, and 62.5 mu g/mL, respectively. The MIC of 4k, 5g, and 6i compounds against Salmonella typhimurium was 31.25 mu g/mL, 100 mu g/mL, and 62.5 mu g/mL, respectively. The MIC of 6i compound against Escherichia coli was 62.5 mu g/mL.
Molecular and supramolecular structures of two polymeric and one trinuclear Cd(II) complex with hydralazine-type ligands were presented.
DMB (Dimethylbarbituric) and DETB (Diethylthiobarbituric) are both barbituric and thiobarbituric acid derivatives respectively, that forms enamines with the Nα amine of amino acids.