KEY ANSWER

• المقرر الدراسي: صكل 313

True and false questions:

 

1. It safe to use Ezetimibe in women at any circumstance.       [             ]

 

The answer {wrong, Safety y and efficacy have not been established; use during pregnancy only if t he potential benefit t o t he mother outweighs t he possible risk t o t he fetus.  Also, it’s Excretion in breast m ilk is unknown so it is not recommended during lactation}

 

1. Ezetimibe is available as oral tablet 20 mg and 10 mg.    [             ]

 

The answer {wrong, only 10 mg}

 

1. Take at any time of day, with regard for meals.   [             ]

 

The answer {wrong, Take at t he same time of day, without regard for meals.}

 

1. Dosing adjustment is necessary for renal impairment and hepatic Impairment patients.   [             ]

 

The answer {wrong, No dosing adj ust m ent necessary}

 

 

Fill in the blanks:

 

1. I f using concurrent Simvastatin in patient s with moderate to- severe renal          impairment, the manufacturer of Ezetimibe recommends that Simvastatin doses exceeding …20 mg…. be used with caution and close monitoring for adverse events.

 

 

1. Ezetimibe Oral dose for adult is …10 mg\day…… and for Elderly and Children ≥ 10 years are……10 mg\day ….and …10 mg\day ……….. Respectively.

 

 

1. Before initiation of therapy, patient s should be placed on a standard      cholesterol- lowering diet for …6 weeks…… and the diet should be  ………continued……….. during drug therapy.