Synthesis and antimicrobial potential of spirooxindolopyrrolidine tethered oxindole heterocyclic hybrid against multidrug resistant microbial pathogens
Infectious diseases are a major public health concern worldwide and a leading cause of morbidity and mortality. Spirooxindolopyrrolidine moiety is attractive in this connection, because this structural unit predominates in many biologically relevant natural alkaloids and displayed multifarious biological profiles including antimicrobial activities. In present study, we have synthesized new class of spirooxindolopyrrolidine hybrid heterocycles employing multicomponent cycloaddition methodology. Compound thus synthesized were evaluated for their antimicrobial activity against common microbial pathogens. Of the compounds 4a-d, the compound 4b bearing trifluoromethoxy unit on the oxindole ring exhibited significant antimicrobial activity with an inhibition range from 7.00 ± 0.15 to 20.00 ± 0.08 mm and MIC value from 8.00 to >256.00 μg/mL against selected microbial pathogens. Hence, the compound 4b was a potential candidate to compacting infectious diseases causing microbial pathogens. The overall results of this study indicated that compound 4b has higher potential activities against both multidrug-resistant bacteria and fungal pathogens. Further research studies are needed to fully understand their medicinal properties of new hybrid heterocycles that are being developed in our laboratory for potential therapeutic development to treat various diseases caused by microbial pathogens.
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