تجاوز إلى المحتوى الرئيسي
User Image

Dr. Abdulwahed Fahad Alrefaei

Associate Professor

Faculty member in Ecology and Molecular Epidemiology

كلية العلوم
Zoology Department, College of Sciences, ground floor, Office No. AB 58
المنشورات
مقال فى مجلة
2021

Comparison of the SARS-CoV-2 (2019-nCoV) M protein with SARS-CoV and MERS-CoV infections

, ALHARBI S. and ALREFAEI A. F. . 2021

Coronaviruses M proteins are well-represented in the major protein component of the viral envelope. During the viral assembly, they play an important role by association with all other viral structural proteins. Despite their crucial functions, very little information regarding the structures and functions of M proteins is available. Here we utilize bioinformatic tools from available sequences and 3D structures of SARS-CoV, SARS-CoV2, and MERS-CoV M proteins in order to predict potential B-cell epitopes and assessing antibody binding affinity. Such study aims to aid finding more effective vaccines and recognize neutralizing antibodies. we found some rather exciting differences between SARS-COV-2, SARS-Cov and MERS-CoV M proteins. Two SARS-CoV-2 peptides with significant antigen presentation scores for human cell surface proteins have been identified. The results reveal that N-terminal domains of M proteins of SARS-CoV and SARS-CoV2 are translocated (outside) whereas it is inside (cytoplasmic side) in MERS-CoV.

رقم المجلد
33
مجلة/صحيفة
Journal of King Saud University–Science
الصفحات
1-9
مزيد من المنشورات
publications

The current study aimed to examine thymic stromal lymphopoietin receptor (TSLPR) genetic variation and breast cancer (BC) susceptibility in women in Saudi Arabia.

بواسطة SEMLALI A., ALMUTAIRI M., ALHARBI S., AL AMRI A., ALREFAEI A. F., ALMUTAIRI B., & ROUABHIA M.
2021
publications

Methylenetetrahydrofolate reductase (MTHFR) polymorphism plays a fundamental role in susceptibility to various diseases, including cancers and autoimmune diseases.

بواسطة ALMUTAIRI M., AL-NUMAIR, N., PARINE, N., ALMUTAIRI, B., ALREFAEI, A., ROUABHIA M., SEMLALI, A.
2021
publications

Camptothetin (CPT) is a quinoline alkaloid originally isolated from the Chinese tree, Camptotheca acuminata Decne. CPT was found to have anticancerous and antiviral properties.…

بواسطة DEVASIA R., ALTAF M., ALREFAEI A., MANOHARADAS S.
2021