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عبير محمد علي بن بعيجان

Associate Professor

عضو هيئة التدريس

كلية العلوم
مبنى 5, الدور الثالث,رقم المكتب 258
المنشورات
مقال فى مجلة
2020

Hybrid Mesoporous Silica Nanoparticles Grafted with 2-(tert-butylamino)ethyl Methacrylate-b-poly(ethylene Glycol) Methyl Ether Methacrylate Diblock Brushes as Drug Nanocarrier

Almeataq, Abdullah M Alswieleh 1,*,y, AbeerM Beagan 1,y, Bayan M Alsheheri 1, Khalid M Alotaibi 1, Mansour D Alharthi 1 and Mohammed S . 2020

This paper introduces the synthesis of well-defined 2-(tert-butylamino)ethyl
methacrylate-b-poly(ethylene glycol) methyl ether methacrylate diblock copolymer, which has
been grafted onto mesoporous silica nanoparticles (PTBAEMA-b-PEGMEMA-MSNs) via atom
transfer radical polymerization (ATRP). The ATRP initiators were first attached to the MSN surfaces,
followed by the ATRP of 2-(tert-butylamino)ethyl methacrylate (PTBAEMA). CuBr2/bipy and ascorbic
acid were employed as the catalyst and reducing agent, respectively, to grow a second polymer,
poly(ethylene glycol) methyl ether methacrylate (PEGMEMA). The surface structures of these
fabricated nanomaterials were then analyzed using Fourier Transform Infrared (FTIR) spectroscopy.
The results of Thermogravimetric Analysis (TGA) show that ATRP could provide a high surface
grafting density for polymers. Dynamic Light Scattering (DLS) was conducted to investigate the
pH-responsive behavior of the diblock copolymer chains on the nanoparticle surface. In addition,
multifunctional pH-sensitive PTBAEMA-b-PEGMEMA-MSNs were loaded with doxycycline (Doxy)
to study their capacities and long-circulation time

نوع عمل المنشور
paper
رقم المجلد
15
رقم الانشاء
195
مجلة/صحيفة
molecules
الصفحات
1-12
مزيد من المنشورات
publications

In this study, Cu2+ perchlorate complexes of 3,5-dimetylpyrazole(dmpy), namely
[Cu(dmpy)3(H2O)2](H2O)(ClO4)2 (1), were prepared and characterized by X-ray diffraction (XRD),

بواسطة Mohd. Muddassir, * Abdullah Alarifi, Mohd Afzal, Khulud Abdullah Alshali, Naaser A. Y. Abduh and Abeer Beagan
2020
publications

This work presents the synthesis of pH-responsive poly(2-(diethylamino) ethyl methacrylate)
(PDEAEMA) brushes anchored on hollow mesoporous silica nanoparticles (HMSN-PDEAEMA)
via a…

بواسطة Abeer Beagan 1,*,y , Shatha Lahmadi 1, Ahlam Alghamdi 1, Majed Halwani 2 , Mohammed Almeataq 3, Abdulaziz Alhazaa 4 , Khalid Alotaibi 1 and Abdullah Alswieleh
2020
publications

This paper introduces the synthesis of well-defined 2-(tert-butylamino)ethyl
methacrylate-b-poly(ethylene glycol) methyl ether methacrylate diblock copolymer, which has
been grafted…

بواسطة Abdullah M Alswieleh 1,*,y, AbeerM Beagan 1,y, Bayan M Alsheheri 1, Khalid M Alotaibi 1, Mansour D Alharthi 1 and Mohammed S Almeataq
2020