Hybrid Mesoporous Silica Nanoparticles Grafted with 2-(tert-butylamino)ethyl Methacrylate-b-poly(ethylene Glycol) Methyl Ether Methacrylate Diblock Brushes as Drug Nanocarrier

مقال فى مجلة
Almeataq, Abdullah M Alswieleh 1,*,y, AbeerM Beagan 1,y, Bayan M Alsheheri 1, Khalid M Alotaibi 1, Mansour D Alharthi 1 and Mohammed S . 2020
نوع عمل المنشور
رقم الانشاء
رقم المجلد
تاريخ المؤتمر
ملخص المنشورات

This paper introduces the synthesis of well-defined 2-(tert-butylamino)ethyl
methacrylate-b-poly(ethylene glycol) methyl ether methacrylate diblock copolymer, which has
been grafted onto mesoporous silica nanoparticles (PTBAEMA-b-PEGMEMA-MSNs) via atom
transfer radical polymerization (ATRP). The ATRP initiators were first attached to the MSN surfaces,
followed by the ATRP of 2-(tert-butylamino)ethyl methacrylate (PTBAEMA). CuBr2/bipy and ascorbic
acid were employed as the catalyst and reducing agent, respectively, to grow a second polymer,
poly(ethylene glycol) methyl ether methacrylate (PEGMEMA). The surface structures of these
fabricated nanomaterials were then analyzed using Fourier Transform Infrared (FTIR) spectroscopy.
The results of Thermogravimetric Analysis (TGA) show that ATRP could provide a high surface
grafting density for polymers. Dynamic Light Scattering (DLS) was conducted to investigate the
pH-responsive behavior of the diblock copolymer chains on the nanoparticle surface. In addition,
multifunctional pH-sensitive PTBAEMA-b-PEGMEMA-MSNs were loaded with doxycycline (Doxy)
to study their capacities and long-circulation time

المرفق الحجم
molecules-q2_0.25_or_0.5-2020.pdf 3.21 ميغابايت