An efficient and green procedure for synthesis of rhodanine derivatives by aldol-thia-Michael protocol using aqueous diethylamine medium

Journal Article
Fun, Assem Barakat, Abdullah M. Al-Majid, Hany J. AL-Najjar, Yahia N. Mabkhot, Hazem A. Ghabbour and Hoong-Kun . 2014
Publication Work Type: 
Master
Magazine \ Newspaper: 
RSC Advances
Volume Number: 
4
Pages: 
4909-4916
Publication Abstract: 

A simple, economical, and green approach to the synthesis of rhodanine derivatives using a tandem aldol condensation-thia-Michael addition process in aqueous diethylamine medium was described. The experiment protocol features simple operations, and the products were isolated in high to excellent yields (82–96%). As spontaneous precipitation always occurs at the end of the process, this leads to easy separation of the products via a simple filtration.

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