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Shaun Sabico

Assistant Professor

Assistant Professor and Deputy Director

كلية العلوم
Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, KSU
المنشورات
مقال فى مجلة
2011

Gender differences exist in the association of leptin and adiponectin levels with insulin resistance parameters in prepubertal Arab children

AIM:

Differences in correlations between leptin, adiponectin and insulin resistance in children exist in different ethnic populations. No such information is available in Arab children. This study aims to fill this gap.

METHODS:

Three hundred and twenty-five prepubertal children were recruited in this cross-sectional study. Body mass index (BMI), waist and hip circumferences and fasting glucose were measured by standard procedures. Serum insulin, leptin and adiponectin were assayed by ELISA.

RESULTS:

Leptin and adiponectin levels were significantly correlated with anthropometric parameters, HOMA-IR and insulin in all subjects and with fasting glucose in girls only. Correlations of adiponectin with HOMA-IR and insulin in boys and of leptin with insulin in girls were independent of BMI, waist and hip circumferences.

CONCLUSION:

Gender differences exist in the distribution of adipocytokines in prepubertal children. The associations of adipocytokines with obesity biomarkers in prepubertal children suggest a causal link between childhood obesity and the risk of an early diabetes onset.

نوع عمل المنشور
Observational
رقم المجلد
24
رقم الانشاء
7-8
مجلة/صحيفة
Journal of Pediatric Endocrinology and Metabolism 2011
الصفحات
427-432
مزيد من المنشورات
publications

Hyperglycemia associated with prediabetes (PD) alters NLRP3 inflammasome activity and related interleukins, yet no study has evaluated the expression of the NLRP3 inflammasome complex and related…

بواسطة Alfadul H, Sabico S, Alnaami AM, Amer OE, Hussain SD, Wani K, Clerici M, Al-Daghri NM
2023
تم النشر فى:
MDPI
publications

Objectives

بواسطة Aljuraiban GS, Algabsani S, Sabico S, Alshammari S, Aljazairy E, Al-Musharaf S
2023
تم النشر فى:
Elsevier
publications

The Metabolically Healthy Obese (MHO) is a unique phenotype of obesity in which individuals match the operational definition of obesity but do not display metabolic complications. Given this…

بواسطة Kaiser Wani , Balvir Kumar , Iram Saba , Shaun Sabico
2023
تم النشر فى:
Biolife Sas