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Omar Salem Abdullah Al-Attas

Professor

Biochemistry

كلية العلوم
Office NO:2A 59
المنشورات
مقال فى مجلة
2003
تم النشر فى:

Association between Taq IB cholesterol ester transfer protein polymorphism and low HDL cholesterol concentration in Saudis.

, Al-Daghri N, Al-Attas O.S, Patel A, Belyaev ND, Bartlett WA, Jones AF, Kumar S, Bain SC. . 2003

lasma concentrations of HDL (high-density lipoprotein) cholesterol are low in the Saudi Arabian population. A B polymorphism at the CETP (cholesteryl ester protein transfer) locus that is detectable with the restriction enzyme Taq I is a genetic determinant of the plasma HDL cholesterol concentration. We assessed the relationship between the Taq I B CETP polymorphism and lipid and apolipoprotein concentrations in a study sample of 335 Saudi residents. The Taq I B1 and B2 allele frequencies were 0.54 and 0.46 respectively, similar to those in other populations. HDL cholesterol levels in B2B2 homozygotes were significantly higher than in B1B1 homozygotes [1.01 (0.3) compared with 0.92 (0.2) mmol/l; mean (S.D.); P=0.03]. There was also a significant difference between the B2B2 and B1B1 homozygotes with regard to apolipoprotein AI concentration [123.6 (16.4) compared with 113.7 (13.9) mg/dl; P=0.04]. This genetic variation was independent of metabolic risk factors known to influence HDL cholesterol levels. The allele frequency of the Taq I B CETP polymorphism and its relatively modest impact on HDL cholesterol concentrations argue against an important role for this allele, or for strongly linked loci, in determining the low levels of HDL cholesterol seen in the Saudi population.

نوع عمل المنشور
PHD
رقم المجلد
105(4)
مجلة/صحيفة
Clinical Science
الصفحات
467-472
مزيد من المنشورات
publications

Abstract
Objectives: To assess circulating fetuin A and fetuin B levels in participants with and without Gestational Diabetes Mellitus (GDM) and to find out their correlations with other…

بواسطة Sobhy M Yakout 1, Samira Hussein 1, Omar S Al-Attas 1, Syed D Hussain 1, Gamal M Saadawy 1, Nasser M Al-Daghri 1
2023
publications

Abstract

بواسطة Kaiser Wani 1, Malak N K Khattak 1, Gamal M Saadawy 1, Omar S Al-Attas 1, Majed S Alokail 1, Nasser M Al-Daghri 1
2023
publications

Abstract

بواسطة Sobhy Yakout 1, Fatimah Faqeeh 1, Omar Al-Attas 1, Syed D Hussain 1, Nasser M Al-Daghri 1
2021