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OBJECTIVES
This course is designed to acquaint the student with the fundamental concepts of clinical pharmacokinetics, particularly during chronic drug therapy. This understanding is of importance in view of:
a) Changes in dosage requirements due to the changes in the state of the patient during course of the disease.
b) Changes in hepatic and renal function that require adjustment in dosage regimens. Knowledge of these principles is necessary to select a drug product or to suggest a dosage regimen for an individual patient.
Course Contents
1. Bioavailability (2 weeks)
· Rate and extent of absorption
· Methods of estimation
· Effect of food
· Disease states
· Digoxin example
· Phenytoin example
· Problem solving
2. Clearance (2 weeks)
· Physiology
· Concepts
· Hepatic blood flow, propranolol example
· Effect of various factors
· Michaelis-menton kinetics
· Problem solving
3. Protein binding (1 week(
· Effect of various factors
· Levels and volume of distribution
· Drug elimination
· Methodology
· Problem solving
4. Detoxification and dialysis (1 week)
· Kinetics factors
· Effect of disease
· Hemodialysis
· Problem solving
5. Volume of distribution (1 week)
· Concepts
· Various terms and their implications
· Disease states
· Problem solving
6. Pharmacodynamics (1 week)
· Concepts
· Models
· Selecting a model
· Problem solving
7. Drug interactions (1 week(
· Gastrointestinal absorption
· Protein binding
· Metabolism - induction or inhibition
· Renal excretion
· Disease states
· Problem solving
8. Model-independent kinetics (1 week)
· Statistical moment theory
· Problem solving
9. Use of computer in modeling (1 week(
· WinNonlin
· SIMKIN
· Other packages (if available)
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