أ.د. هشام سليمان ابوعوده

PHCL 462:  CLINICAL PHARMACOKINETICS   (0+1)

Course Description The clinical pharmacokinetics course is designed to enable the students to understand how various disease states alter the pharmacokinetic parameters. It provides the students with the principles for dosing patients more rationally and safely. Course Objectives By the successful completion of this course, students will be able to: 1.  Apply the pharmacokinetic principles to specific drug-related problems commonly encountered in practice setting. 2.  Discuss clinical pharmacokinetic parameters, serum plasma levels, equations which express the relationship between the various parameters and pathophysiological factors which influence the pharmacokinetics of selected drugs and their significance. 3.  Evaluate pharmacokinetic principles, develop, adjust and interpret dosage regimens as well as serum blood levels in a clinical setting.        Course Contents                                                                   No. of Lab. Review of pharmacokinetic terms and parameters.                       1 Its significance to clinical pharmacokinetics                                1 Therapeutic drug monitoring.                                                   1 The following drugs will be studied with respect to dosing information, therapeutic range, relevant pharmacokinetic equations, serum concentration monitoring, steady-state      times, sample times and interpretation of serum drug levels:                     a)    Aminoglycosides                                                 2                     b)    Theophylline                                                      1                     c)    Digoxin                                                             1                     d)    Lidocaine                                                          1                     e)    Phenytoin                                                         1                     f)     Valproic acid                                                     1                     g)    Methotrexate                                                    1                     h)    vaneomyein and Lithium                                      1                     i)     Carbamazepine                                                  1                     j)        Primidone                                                         1  Textbook: Michael E.Winter. Basic Clinical Pharmacokinetics (Fourth Edition), Lippincott Williams & Wilkins, 2003. 511 pages ISBN: 0781741475, 9780781741477 Important:  The book is available on the Internet as a fulltext in pdf format as one of Google Books. Click on the name of the book above to access the text.