Venom-Induced Lipid Peroxidation
We studied time-course of lipid peroxidation in different vital organs (brain, heart, kidney, liver and lung) of mice to better understand the pathogenesis of snake envenomation. The level of malondialdehyde (MDA), an index of lipid peroxidation, was analyzed spectrophotometrically.
Figure. Time-course presentation of snake venom-induced lipid peroxidation in different organs of mice, shown as percent of control values (mice without envenomation).
The results showed that a single injection of EP caused significant lipid peroxidation in all the organs studied. In all the organs, the onset of lipid peroxidation was as early as 1 hour and persisted for several hours suggesting an important role of oxidative stress in the cytotoxicity of EP venom .
Al Asmari A, Al Moutaery K, Manthari RA, Khan HA. Time-course of lipid peroxidation in different organs of mice treated with Echis pyramidum snake venom. J Biochem Mol Toxicol 2006; 20: 93-95.