introduction/brief CV
BIOGRAPHY:
Wael Alanazi earned his bachelor’s degree in Pharmaceutical Sciences from King Saud University in 2011. After graduation, Wael worked for the Drug Sector at Saudi Food and Drug Authority (SFDA) for evaluation of the quality of pharmaceutical products. In 2012, he worked as a teaching assistant in the Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University. In 2013, Wael started his doctoral research in the Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, USA. He joined Dr. Jackson’s laboratory and completed his thesis entitled “The role of recurrent insulin-induced hypoglycemia on renal prostanoids production, (pro)renin receptor expression and oxidative stress in heart and kidney”. In 2016, Wael earned his Ph.D. in Pharmacology and published several peer-reviewed articles. In 2017, Dr. Wael joined the Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University as an assistant professor, and was promoted to associate professor in 2021.
RESEARCH INTERESTS:
- Study the antidiabetic activities of new synthetic compounds, and their mechanism of action in glycemic control.
- Identify novel therapeutic strategies for prevention of diabetes-induced renal and cardiovascular diseases in various animal models of diabetes.
- Investigate the roles of renin angiotensin system, cyclooxygenases and oxidative stress in diabetic complications.
- Finding the link between blood glucose levels and different vicious pathways causing kidney damage and hypertension in hypoglycemic and/or hyperglycemic animal models.
areas of expertise
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Teaching Experience:
Extensive teaching experience in biochemistry, pharmacology, and toxicology for undergraduate, graduate, and doctoral students, including:
- Undergraduate Courses:
- Pathophysiology, Drug Action, and Therapeutics-1 (PDAT1)
- Pharmacology I & III – Pharmacy students
- Pharmacology in Dentistry – Dental medicine students
- Fundamentals of Biochemistry of Diseases – Pharmacy students
- Graduation project – Pharmacy students
- Master’s Level Courses:
- Toxicology of Drugs of Abuse
- Pharmacological Screening
- Advanced Pharmacology II
- Biochemical Toxicology
- Physiological Chemistry
- Doctoral Level Course:
- Drug Discovery and Development – Pharmacy PhD students
- Research Methods in Pharmacology – Pharmacy PhD students
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Laboratory Rotation – Pharmacy PhD students
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Research Experience:
Comprehensive research experience with a focus on the molecular mechanisms of diabetes and its cardiovascular and renal complications. Specific expertise includes:
- Animal Models & In Vivo Studies:
- Development of hypertensive rodent models
- Development of hypoglycemic and hyperglycemic rodent models for acute and chronic studies
- Proficient in drug administration via intraperitoneal, subcutaneous, and oral routes
- Skilled in rodent surgeries including catheterization of carotid artery, jugular vein, and urinary bladder
- Analytical Techniques & Equipment:
- Non-invasive blood pressure monitoring using CODA® High Throughput System
- Renal microdialysis for interstitial fluid sampling
- Electron Paramagnetic Resonance (EPR) Spectroscopy
- Renal clearance analysis using IL943 Automatic Flame Photometer
- Hematological analysis via PCE-210N Blood Cell Counter
- ELISA and EIA for biomarker detection
- Gene expression analysis using QuantStudio™ 6 Flex Real-Time PCR System
- Protein analysis via Western blotting
- Bioanalysis of plasma and tissue samples
- Software Proficiency:
- CODA® Data Acquisition, Hatteras Instruments, BIOPAC MP150
- GraphPad Prism®, GraphPad Instat
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Gen 5™ Microplate Data Collection & Analysis Software
- Committee Service:
- Member, Scientific Research Ethics Committee, King Saud University, Riyadh, Saudi Arabia. (September 2024 - Present).
- Chair, Graduate Students Affairs Committee, Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. (August 2023- Present).
- Vice Chair, Disciplinary Subcommittee, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. (November 2022- Present).
- Member, Pharmacy Education Unit, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. (May 2021- Present).
- Chair, Academic Affairs Committee, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. (October 2019- November 2020).
- Chair, Teaching Load Committee, Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. (January 2019- September 2021).
