CV
PhD Biochemistry 2008-2012 Annamalai University, India Highly recommended
MPhil Biochemistry 2006-2008 Annamalai University, India First class
MSc Biochemistry 2004-2006 Bharathidasan University, India First class
BSc Biochemistry 2001-2004 Madras University, India first class
Employment History
1. 2 year -Postdoctoral Researcher Feb 2017- Aug 2018 Molecular and Genetic Aspects of Guanylyl Cyclase Natriuretic Peptide Receptor-A in Regulation of Blood Pressure and Renal Function
2. 2 year -Postdoctoral Researcher April 2015- Jan 2017 Small animal in vivo imaging, tracking live pathogens, noninvasively imaging xenograft, drug delivery, and fluorescent nanoparticle-biodistribution
3. 2 year-Full time lecture/ Postdoctoral Researcher Feb 2013-Feb 2015 Role of TRPV1 activate on CD4+ T cells mediated inflammatory response in allergic rhinitis
4. 3 months-Postdoctoral Researcher
Nov 2012-Jan 2013 Hypoxia induced ROS generation stimulate adipose-derived stem cell proliferation and differentiation into various progenitor cells
5. 3 year-JRF/SRF (DST Fast Track project) 2008-2011
Evaluation of protective effect of sesamol on UVB-radiation induced cellular changes in cultured human skin dermal fibroblasts
M.Phil/Ph.D. Candidates guided/awarded : 14 Editorial Activity/Journal Reviewer: Molecular and Cellular Biochemistry, Biochemie, European Journal of Pharmacology, Chemico-Biological Interaction, Human & Experimental Toxicology Journal of Cancer Research and Therapeutics Number of Publications (International): 30 List of publications : 1. Subramanian U, Ramasamy C, Ramachandran S, Oakes JM, Gardner JD, Pandey KN. Genetic Disruption of Guanylyl Cyclase/Natriuretic Peptide Receptor-A Triggers Differential Cardiac Fibrosis and Disorders in Male and Female Mutant Mice: Role of TGF-β1/SMAD Signaling Pathway. Int J Mol Sci. 2022;23(19):11487. 2. Ramachandran S, Saud AA, Ibraheem SA, Adnan AK, Omar K, Essam SA, Masmali AM. Translocation of pro-apoptotic proteins through basements membrane and hemidesmosome in the corneal epithelium of the keratoconus subjects. J King Saud University-Science. 2022;34(8):102328. 3. Akhtar S, Smedowski A, Masmali A, Alkanaan A, Khan AA, Almutleb E, Mofty HK, Al-Debasi HI, Samivel R, Almubrad T. Effect of Ultraviolet-A and Riboflavin treatment on the architecture of the center and periphery of normal rat cornea: 7 days post treatment. Exp Eye Res. 2022;219:109064. 4. Akhtar S, Samivel R, Smedowski A, Alkanaan A, Masmali A, Kirat O, Khan AA, Almubrad T. A unique pre-endothelial layer at the posterior peripheral cornea: ultrastructural study. Sci Rep. 2022;12(1):2556. 5. Samivel R, Subramanian U, Ali Khan A, Kirat O, Masmali A, Almubrad T, Akhtar S. Lipopolysaccharide Enhances Genotoxicity by Activating GADD45G and NF-κB in Human Corneal Epithelial Cells. Oxid Med Cell Longev. 2022;2022:4328116. 6. Akhtar S, Samivel R, Smedowski A, Alkanaan A, Masmali A, Kirat O, Khan A, Almubrad TA. A unique pre-endothelial layer at the posterior peripheral cornea: ultra-structural study. Acta Ophthalmol, 2022;100:. https://doi.org/10.1111/j.1755-3768.2022.030. 7. Akhtar S, Almubrad T, Smedowski A, Samivel R, Almutleb E, Alkanaan A, Khan A, Masmali A, Mencucci R. Ultrastructure of collagen fibrils, proteoglycans and lamellae of the human cornea treated with Iontophoresis - UVA cross-linking and hypotonic riboflavin solution. Acta Ophthalmol, 2022;100:. https://doi.org/10.1111/j.1755-3768.2022.032. 8. Almubrad T, Mencucci R, Smedowski A, Samivel R, Almutleb E, Alkanaan A, Khan AA, Masmali A, Akhtar S. Ultrastructural study of collagen fibrils, proteoglycans and lamellae of the cornea treated with iontophoresis - UVA cross-linking and hypotonic riboflavin solution. Saudi J Biol Sci. 2021;28(12):7160-7174. 9. Kumar P, Neelamegam K, Samivel R, Xia H, Ramasamy C, Zhao H, Nguyen C, Gogulamudi V, Kapusta D, Pandey KN. Regulation of Blood Pressure and Renal Fibrosis by Class I Specific HDAC Inhibitor, Mocetinostat, in Npr1 Gene-targeted Male and Female Mice. The FASEB Journal, 2021;35: https://doi.org/10.1096/fasebj.2021.35.S1.03773. 10. Samivel R, Nagarajan RP, Subramanian U, Khan AA, Masmali A, Almubrad T, Akhtar S. Inhibitory Effect of Ursolic Acid on Ultraviolet B Radiation-Induced Oxidative Stress and Proinflammatory Response-Mediated Senescence in Human Skin Dermal Fibroblasts. Oxid Med Cell Longev. 2020;2020:1246510. 11. Arise KK, Kumar P, Samivel R, Zhao H, Lindsey S, Pandey KN. Angiotensin II Represses Guanylyl Cyclase/Natriuretic Peptide Receptor-A Gene Expression and Receptor Signaling and Function. The FASEB Journal, 2020;34:1-1. https://doi.org/10.1096/fasebj.2020.34.s1.02216. 12. Arise KK, Kumar P, Garg R, Samivel R, Zhao H, Pandya K, Nguyen C, Lindsey S, Pandey KN. Angiotensin II represses Npr1 expression and receptor function by recruitment of transcription factors CREB and HSF-4a and activation of HDACs. Sci Rep. 2020;10(1):4337. 13. Samivel R, Subramanian U, Oakes JM, Chen H, Zhao H, Gardner JD. and Pandey KN. Blockade of Cardiac Hypertrophy and Fibrosis by TGF-Beta 1 Receptor Antagonist in Npr1 Gene-Knockout Mice. The FASEB Journal, 2019;33: 531.10-531.10. https://doi.org/10.1096/fasebj.2019.33.1_supplement.531.10. 14. Umadevi Subramanian, Ramachandran S, Hanqing Zhao, Venkateswara Gogulamudi, and Kailash N Pandey. Abstract 101: Transforming Growth Factor-Beta-Receptor Antagonist Blocks the Cardiac Fibrosis and Remodeling in Guanylyl Cyclase/Natriuretic Peptide Receptor-A Gene-Disrupted Mice. Hypertension, https://doi.org/10.1161/hyp.72.suppl_1.101Hypertension. 2018; 72: A101. 15. Prerna Kumar, Venkateshwara R. Gogulamudi, Christian Nguyen, Ramachandran Samivel, Kailash N. Pandey. Inhibition of Class I HDAC Enhances the Expression of Npr1 and Repairs Renal Pathology in Gene-targeted Haplotype Mice. Hypertension, 2017; P161 16. Ramachandran S, Thiyagarajan Dhinakar Raj G, Uma A. Non-invasive in vivo imaging of fluorescence-labeled bacterial distributions in aquatic specie. International Journal of Veterinary Science and Medicine 5 (2), 187-195, 2017. 17. Ramachandran S, Eun Hee Kim, Jie Hye Kim, Young-Jun Chung, Ji-Hun Mo. XXIV World Allergy Congress 2015, World Allergy Organization Journal, 2016; 9(1): 14, ISSN 1939-4551, https://doi.org/10.1186/s40413-016-0096-1. 18. Ramachandran S, Eun Hee Kim, Jie Hye Kim, Ji Eun Kwon, Jin-Chul Ahn,Young-Jun Chung, Ji-Hun Mo. Role of TRPV1 activate on CD4+ T cells mediated inflammatory response in allergic rhinitis. Oncotarget, 2015. (IF. 6.2) 19. Eun Hee Kim, Jie Hye Kim, Ramachandran Samivel, Jun-Sang Bae, Young-Jun Chung, Phil-Sang Chung, Shee Eun Lee, Ji-Hun Mo. Intralymphatic treatment of flagellin-ovalbumin mixture reduced allergic inflammation in murine model of allergic rhinitis. Allergy, 2016. (IF. 5.8) 20. Ramachandran S, Eun Hee Kim, Young-Jun Chung, Ji-Hun Mo. Immunomodulatory effect of tonsil-derived mesenchymal stem cells in a mouse model of allergic rhinitis. American Journal of Rhinology & Allergy, 2015 Jul;29(4):262-7. (IF. 2) 21. Ki-Il Lee, Dae Woo Kim,Eun Hee Kim, Jie Hye Kim, Ramachandran S, Ji Eun Kwon, Jin-Chul Ahn,Young-Jun Chung, Ji-Hun Mo. Cigarette smoke promotes eosinophilic inflammation, airway remodeling, and nasal polyps in a murine polyp model. American Journal of Rhinology & Allergy, May–June 2014, Vol. 28, No. 3.(IF. 2) 22. G. Kanimozhi, S. Ramachandran, N. Rajendra Prasad, K. V. Pugalendi. Umbelliferone protects whole body irradiated Swiss albino mice: Study on animal survival, tissue antioxidant status and DNA damage. Biomedicine & Preentive Nutrition, 2012; (IF- 0.5) 23. S. Ramachandran, N. Rajendra Prasad. Sesamol modulates UVB-induced apoptotic and inflammatory signaling in human skin dermal fibroblasts. Int J Nutr Pharmacol Neurol Dis. 2011; 1: 1-9. 24. S. Ramachandran, N. Rajendra Prasad. Sesamol, a phenolic in sesamum indicum, inhibits photocarcinogenesis by targeting UVB-induced lipid peroxidation and antioxidation depletion in Swiss albino mice. Journal of Research Biochemistry, 2011; 1: 001-008. 25. G. Kanimozhi, S. Ramachandran, N. Rajendra Prasad, K. V. Pugalendi. Umbelliferone modulates gamma-radiation induced ROS generation and subsequent oxidative damage in human blood lymphocytes. European Journal of Phormacology, 2011; 672(1-3): 20-29. (Impact factor: 2.8). 26. S. Ramachandran, N. Rajendra Prasad, S. Karthikeyan. Sesamol inhibits UVB-induced ROS generation and subsequent oxidative damage in cultured human skin dermal fibroblasts. Arch Dermatol Res (2010): 1–11 (Impact factor: 2.01). 27. N. Rajendra Prasad, K. Jeyanthimala and S. Ramachandran. Caffeic acid modulates ultraviolet radiation-B induced oxidative damage in human blood lymphocytes, Journal of Photochemistry & Photobiology 95/3 (2009) 196-203 (Impact factor: 2.2). 28. S. Ramachandran, N. Rajendra Prasad, Effect of ursolic acid, a triterpenoid antioxidant, in ultraviolet radiation induced cytotoxicity, lipid peroxidation and DNA damage in human lymphocytes. Chemico-Biological Interactions 176 (2008) 99–107 (Impact factor: 3.2). 29. S. Ramachandran, N. Rajendra Prasad, K.V. Pugalendi, Venugopal P. Menon Modulation of UVB-induced oxidative stress by ursolic acid in human blood lymphocytes, Asian Journal of Biochemistry 3 (1) (2008) 11-18. (Impact factor: 0.5). 30. N. Rajendra Prasad, S. Ramachandran, K.V. Pugalendi, V.P. Menon. Ferulic acid inhibits UVB induced oxidative stress, Nutrition Research 27 (9) (2007) 559-564 (Impact factor: 1.8 Important Research Article Published : Subramanian U, Ramasamy C, Ramachandran S, Oakes JM, Gardner JD, Pandey KN. Genetic Disruption of Guanylyl Cyclase/Natriuretic Peptide Receptor-A Triggers Differential Cardiac Fibrosis and Disorders in Male and Female Mutant Mice: Role of TGF-β1/SMAD Signaling Pathway. Int J Mol Sci. 2022;23(19):11487.