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Ahlam Mohammed Omar Alhusaini

Assistant Professor

عضو هيئة تدريس

كلية الصيدلة
كلية الصيدلة - الدور الثاني - مكتب رقم 25

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aelhusaini
cv

Ahlam Mohammed Omar Alhusaini

Bio
Associate Professor
Department of Pharmacology and Toxicology
College of Pharmacy
King Saud University
CV Text

Qualifications:

  • PhD degree in Pharmacology (Neuroscience), School of Pharmacy, Reading, United Kingdom (2016).
  • Personal license to carry out regulated scientific procedures on living animals from British Home Office (2013).
  • Master’s degree in Toxicology, Pharmacology Department, Pharmacy College, King Saud University.
  • Bachelor’s degree in general pharmacy, Pharmacy College, King Saud University.

Experience:

  • Lecturer in Pharmacology Department – King Saud University (2006 – 2016).
  • Assistant professor in Pharmacology Department – King Saud University (2017 – 2020).
  • Head of student support and guidance unit at College of Pharmacy (2017).
  • Vice chair of the department of Pharmacology and Toxicology (2018 – 2020).
  • Associate professor – Pharmacology Department – King Saud University (2021 – Now).

Skills:

  • Animal models
  • Electrophysiology technique (MEA and current clamp).
  • Immunohistochemistry technique.
  • Western blot technique.

Activities:

  • Member in the Saudi Pharmaceutical Society (SPS).
  • Member in the British Neuroscience Association (BNA).
  • Member in the Federation of European Neuroscience Societies (FENS).
  • Member in the American Association of Pharmaceutical Scientists (AAPS).
  • Senior supervisor in a research group.

Committees

  1. Representative of the Department of Pharmacology, Academic Committee, Faculty of Pharmacy.
  2. Member of the supervisory committee for the animal house laboratory at the Department of Pharmacology and Toxicology.
  3. Member of the annual report committee at the Department of Pharmacology and Toxicology.
  4. Member of Postgraduate Program Development Committee at the Department of Pharmacology and Toxicology.

Poster presentation

  1. Shahad Al-Ghilani, Waad Alhuqbani, Ahlam Alhusaini, Iman Hasan. (2020). The potential protective effect of Vitamin E and lactobacillus against HgCl2-induced hepatotoxicity: Role of CHOP, GPR87 and mTOR proteins. Duphat, Dubai.
  2. Bashayer Al-Rumayyan, Khansa Al-Anazi, Rawan Al-Masoud, Sara Al-Marshad, Marwa Al-Esikri. Iman Hussein and Ahlam Alhusaini. (2019). Neuroprotective Efficacy of Nano-COQ Against Propionic Acid Toxicity in rats: Role of BDNF and CREB Protein Expression. Poster presentation at 10th Scientific workshop, King Saud University.
  3. Azizah Aldosari, Bshayer Alharbi, Njood Alsaadan, Nouf Aldowsari, Laila Fadda, Iman Hussein and Ahlam Alhusaini. (2018). Curcumin Attenuates the Incidence of Oxidative Stress, Inflammation and DNA Damage-Induced by Copper Sulfate in Rat’s Liver. Poster presentation at 9th Scientific workshop, King Saud University.
  4. Sumaysh Jarallah, Shroug Alghamdi, Norah Alhadab, Laila Fadda, Iman Hussein and Ahlam Alhusaini. (2017). Vitamin C and Turmeric Attenuate Bax and Bcl-2 Protein Expression and DNA Damage in Lead Acetate-Induced Liver Injury. Oral presentation at 8th Scientific workshop, King Saud University.
  5. A. Alhusaini, B. Whalley. (2016). Initial electrophysiological characterization of changes in epileptic olfactory cortex in the refined lithium-pilocarpine, murine model of spontaneous recurrent seizures. Poster presentation at 9th Saudi Students Conference, Birmingham, UK.
  6. A. Alhusaini, C. Williams, B. Whalley. (2014). The Reduced Intensity Status Epilepticus (RISE) model of epileptogenesis and its characterization on rat piriform cortex. Poster presentation at 7th Saudi Students Conference, Edinburgh, UK.
  7. Peres, R. Hadid, N. Amada, C. Hill, A. Alhusaini, C.M. Williams, B.J. Whalley. (2013). The phytocannabinoid cannabidivarin demonstrates notable antiepileptic properties and is a genuine candidate for the treatment of temporal lobe epilepsy. Poster presentation at Society for Neuroscience Conference, San Diego, USA.

Journal publications

  1. Alhusaini A, Sarawi W, Mattar D, Abo-Hamad A, Almogren R, Alhumaidan S, Alsultan E, Alsaif S, Hasan I, Hassanein E, Mahmoud A. Acetyl-L-carnitine and/or liposomal co-enzyme Q10 prevent propionic acid-induced neurotoxicity by modulating oxidative tissue injury, inflammation, and ALDH1A1-RA-RARα signaling in rats. Biomed Pharmacother. 2022 Jul 1;153:113360. doi: 10.1016/j.biopha.2022.113360. 
  2. Sarawi WS, Alhusaini AM, Fadda LM, Alomar HA, Albaker AB, Alghibiwi HK, Aljrboa AS, Alotaibi AM, Hasan IH, Mahmoud AM. Nano-Curcumin Prevents Copper Reproductive Toxicity by Attenuating Oxidative Stress and Inflammation and Improving Nrf2/HO-1 Signaling and Pituitary-Gonadal Axis in Male Rats. Toxics. 2022 Jun 30;10(7):356. doi: 10.3390/toxics10070356.
  3. Ahlam Alhusaini, Laila Fadda, Leena Albogami, Noura Alnaim, Wedad Sarawi, Dareen Mattar, Iman Hasan. Liposomal coenzyme Q10 abates inflammation, apoptosis and DNA damage induced by an overdose of paracetamol in rat's liver. 2022. Journal of King Saud University – Science; 34(6), 102144, ISSN 1018-3647
  4. Alshanwani AR, Hagar H, Shaheen S, Alhusaini AM, Arafah MM, Faddah LM, Alharbi FM, Sharma AK, Fayed A, Badr AM. A promising antifibrotic drug, pyridoxamine attenuates thioacetamide-induced liver fibrosis by combating oxidative stress, advanced glycation end products, and balancing matrix metalloproteinases. Eur J Pharmacol. 2022 May 15;923:174910. doi: 10.1016/j.ejphar.2022.174910.
  5. Badran MM, Alouny NN, Aldosari BN, Alhusaini AM, Abou El Ela AS. Transdermal Glipizide Delivery System Based on Chitosan-Coated Deformable Liposomes: Development, Ex Vivo, and In Vivo Studies. Pharmaceutics. 2022 Apr 10;14(4):826. doi: 10.3390/pharmaceutics14040826.
  6. Alhusaini AM, Fadda LM, Alanazi AM, Sarawi WS, Alomar HA, Ali HM, Hasan IH, Ali RA. Nano-Resveratrol: A Promising Candidate for the Treatment of Renal Toxicity Induced by Doxorubicin in Rats Through Modulation of Beclin-1 and mTOR. Front Pharmacol. 2022 Feb 25;13:826908. doi: 10.3389/fphar.2022.826908. 
  7. Alhusaini A, Fadda L, Sarawi W, Alomar H, Ali H, Mahamad R, Hasan I, Badr A. The Potential Protective Effect of Curcumin and α-Lipoic Acid on N-(4-Hydroxyphenyl) Acetamide-induced Hepatotoxicity Through Downregulation of α-SMA and Collagen III Expression. Dose Response. 2022 Feb 24;20(1):15593258221078394. doi: 10.1177/15593258221078394.
  8. Alhusaini AM, Fadda LM, Alsharafi H, Alshamary AF, Hasan IH. L-Ascorbic Acid and Curcumin prevents Brain Damage-induced via Lead Acetate in Rats: Possible Mechanisms. Dev Neurosci. 2021 Dec 23. doi: 10.1159/000521619. Epub ahead of print. PMID: 34942627.
  9. Ahlam M. Alhusaini, Abeer M. Alanazi, Laila M. Fadda, Qamraa H. Alqahtani, Wedad S. Sarawi, Iman H. Hasan. The beneficial efficacy of liposomal resveratrol against doxorubicin-induced hepatotoxicity in rats: Role of TGF-β1 and SIRT. 2021Oct. Journal of King Saud University - Science 33(3):101640. DOI:10.1016/j.jksus.2021.101640
  10. Sarawi WS, Alhusaini AM, Fadda LM, Alomar HA, Albaker AB, Aljrboa AS, Alotaibi AM, Hasan IH, Mahmoud AM. Curcumin and Nano-Curcumin Mitigate Copper Neurotoxicity by Modulating Oxidative Stress, Inflammation, and Akt/GSK-3β Signaling. Molecules. 2021 Sep 15;26(18):5591. doi: 10.3390/molecules26185591.
  11. Sarawi, W.S.; Alhusaini, A.M.; Fadda, L.M.; Alomar, H.A.; Albaker, A.B.; Aljrboa, A.S.; Alotaibi, A.M.; Hasan, I.H.; Mahmoud, A.M. Nano-Curcumin Prevents Cardiac Injury, Oxidative Stress and Inflammation, and Modulates TLR4/NF-κB and MAPK Signaling in Copper Sulfate - Intoxicated Rats. Antioxidants. 2021 September, 10, 1414. doi.org/10.3390/antiox10091414.
  12. Alhusaini A, Alhumaidan S, Almogren R, Alsaif S, Alsultan E, Hussein I. Nano-Curcumin Protects Against Sodium Nitrite-Induced Lung Hypoxia Through Modulation of Mitogen-Activated Protein Kinases/c-Jun NH2-Terminal Kinase Signaling Pathway. Dose Response. 2021 August; 19(3):15593258211033148. doi: 10.1177/15593258211033148. PMID: 34393686; PMCID: PMC8351036.
  13. Sameerah Shaheen, Maha M Arafah, Aliah R Alshanwani, Laila Mohammed Fadda, Ahlam M Alhusaini, Hanaa M Ali, Iman H Hasan, Hanan Hagar, Fatima M Alharbi, Alaa AlHarthii. Chitosan nanoparticles as a promising candidate for liver injury induced by 2-nitropropane: Implications of P53, iNOS, VEGF, PCNA, and CD68 pathways. Science Progress. April 2021. doi:10.1177/00368504211011839.
  14. Ahlam Alhusaini, Shahad Alghilani, Waad Alhuqbani, Iman H. Hasan. Vitamin E and Lactobacillus Provide Protective Effects Against Liver Injury Induced by HgCl2: Role of CHOP, GPR87, and mTOR Proteins. Dose-Response, 2021 April;19(2):15593258211011360. doi: 10.1177/15593258211011360. PMID: 33994889; PMCID: PMC8083003.
  15. Aliah R. Alshanwani, Azza M.Mohamed, Laila M.Faddah, Sameerah Shaheen, Maha M. Arafah, Hanan Hagar, Ahlam M. Alhusaini, Fatima M.B. Alharbi, Alaa AlHarthii, Amira M. Badr. Cyanocobalamin and /or Calcitriol Mitigate Renal Damage-Mediated by Tamoxifen in Rats: Implication of Caspase -3 / NF-kB Signaling Pathways. Life Sciences. Volume 277, 2021.  in 119512 DOI 10.1016/j.lfs.2021.119512.
  16. Aliah R. Alshanawani, Laila M. Faddah, Hanan Hagar, Ahlam M. Alhusaini, Sameerah Shaheen, Raeesa A. Mohammed, Fatima M. Alharbi, Alaa Alharthi and Amira M. Badr. The beneficial effects of antioxidants combination on cardiac injury induced by tetrachloromethane. Drug Chem. Toxiol. Oct. 2020; 15:1-9. doi: 10.1080/01480545.2020.1831012.
  17. Alshanwani AR, Shaheen S, Faddah LM, Alhusaini AM, Ali HM, Hasan I, Hagar H, Ahmed R, Alharbi FMB, AlHarthii A. Manipulation of Quercetin and Melatonin in the Downregulation of HIF-1α, HSP-70 and VEGF Pathways in Rat's Kidneys Induced by Hypoxic Stress. Dose Response. 2020 Aug 28;18(3): doi: 10.1177/1559325820949797.
  18. Laila M. Fadda, Ahlam M. Alhusaini, Iman H. Hasan, Hanaa M. Ali, Qamraa H. Alqahtani, Enas A. Zakaria, and Abeer Al-anazi. Combination of Vitamin E and Lactobacillius plantarum Reverses Mercuric Chloride-Induced Neurotoxicity: Implication of BDNF, CREB and MAPK Proteins Expressions. Journal of King Saud University - Science. July 2020; 32(5), 2590-2597.
  19. Abeer Alanazi, Laila M. Fadda, Ahlam M. Alhusaini and Rehab Ali. Antioxidant, anti-apoptotic, and anti-fibrotic effects of the combination of liposomal resveratrol and carvedilol against doxorubicin-induced cardiomyopathy in rats. J Biochem. Mol. Toxicol. March 2020; e22492.
  20. Laila M. Fadda, Ahlam M. Alhusaini, Qamraa Alqahtani, Hanaa M. Ali and Iman H. Hasan. Role of α -Tocopherol and Lactobacillus plantarum in the Alleviation of Mercuric Chloride-Induced Testicular Atrophy in Rat's model: implication of Molecular Mechanisms. J Biochem. Mol. Toxicol. 5 March 2020; doi: 10.1002/jbt.22481
  21. Abeer M. Alanazi, Laila Fadda, Ahlam Alhusaini, Rehab Ahmad, Iman H. Hasan and Ayman M. Mahmoud. Liposomal Resveratrol and/or Carvedilol Attenuate Doxorubicin-Induced Cardiotoxicity by Modulating Inflammation, Oxidative Stress and S100A1 in Rats. Antioxidants. 2020; 9(2), 159-175
  22. Ahlam M. Alhusaini, Laila M. Fadda, Iman H. Hasan, Hanaa M. Ali, Amira Badr, Najlaa Elorabi, Hatun Alomar, Qamraa Alqahtani, Enas Zakaria, and Abeer Al-anazi. Role of some natural antioxidants in the down regulation of Kim, VCAM1, Cystatin C protein expression in lead acetate-induced acute kidney injury. Pharmacological Report. 2020: https://doi.org/10.1007/s43440-020-00072-8
  23. Alhusaini A, Hasan IH, Alrumayyan B, Alesikri M, Alanazi K, Almasoud R1, Almarshad S. Neuroprotective efficacy of nano-CoQ against propionic acid toxicity in rats: Role of BDNF and CREB protein expressions. J Biochem. Mol. Toxicol. 2020 Jan 22: e22449. doi: 10.1002/jbt.22449
  24. Ahlam M. Alhusaini, Laila M. Faddah, Iman H. Hasan, Somayah J. Jarallah, Shrouq H. Alghamdi, Norah M. Alhadab1, Amira Badr, Najlaa Elorabi, Enas Zakaria, and Abeer Al-anazi. Vitamin C and Turmeric Attenuate Bax and Bcl-2 Proteins’ Expressions and DNA Damage in Lead Acetate-Induced Liver Injury. Dose-Response: An International Journal. December 2019: 9 pages.
  25. Ahlam Alhusaini, Laila Fadda, Iman H. Hasan, Hanaa M. Ali, Naglaa F. El Orabi, Amira M. Badr, Enas Zakaria, Abeer M. Alanazi and Ayman M. Mahmoud.  Arctium lappa Root Extract Prevents Lead-Induced Liver Injury by Attenuating Oxidative Stress and Inflammation, and Activating Akt/GSK-3β Signaling. Antioxidants 2019, 8, 582; doi:10.3390/antiox8120582
  26. Ahlam Alhusaini, Laila Fadda, Iman H. Hasan, Enas Zakaria, Abeer M. Alanazi and Ayman M. Mahmoud. Curcumin Ameliorates Lead-Induced Hepatotoxicity by Suppressing Oxidative Stress and Inflammation and Modulating Akt/GSK-3_ Signaling Pathway; Biomolecules 2019, 9 (11), 703; https://doi.org/10.3390/biom9110703
  27. Ahlam Alhusaini, Laila Fadda, Hanaa M. Ali, Rehab A. Ali, Iman H. Hasan, Enas Zakaria. Mitigation of acetamiprid – induced renotoxicity by natural antioxidants via the regulation of ICAM, NF-kB and TLR 4 pathways. Pharmacological Reports, 2019, 71 (6), Pages 1088-1094
  28. Laila Fadda, Ahlam Alhusaini, Hanaa M. Ali, Iman Hassan, Amira Badr, Enas Zakaria. Cross Talk Between TGF-β and JAK Expressions and Nephrotoxicity Induced by Tetrachloromethane: Role of Phytotherapy. Dose-Response: An International Journal September 2019: 11 pages.
  29. Ahlam Alhusaini, Iman Hassan, Nouf Aldowsari and Njood Alsaadan. Prophylactic Administration of Nano-curcumin Abates the incidence of Liver Toxicity Induced by an Overdose of Copper Sulfate: Role of CYP4502E1, NF-B and Bax expressions. Dose-Response; An International Journal December 2018: 8 pages.
  30. Ahlam Alhusaini, Laila Faddaa, Hanaa M. Ali, Iman Hassan, Nagla F. El Orabi, and Yieldiz Bassiouni. Amelioration of the Protein Expression of Cox2, NFkB, and STAT-3 by Some Antioxidants in the Liver of Sodium Fluoride–Intoxicated Rats. Dose-Response: An International Journal 2018: 9 pages.
  31. Ahlam Alhusaini, Laila Fadda, Iman Hassan1, Hanaa M. Ali, Njood Alsaadan, Nouf Aldowsari, Azizah Aldosari, and Bshayer Alharbi.  Liposomal Curcumin Attenuates the Incidence of Oxidative Stress, Inflammation, and DNA Damage Induced by Copper Sulfate in Rat Liver. Dose-Response; An International Journal July-September 2018: 8 pages.
  32. Ahlam M. Alhusaini, Laila M. Faddah, Naglaa F. El-Orabi, Iman H. Hasan. Role of some natural antioxidants in the modulation of some proteins expressions against sodium fluoride induced renal injury. BioMed Research International, vol. 2018, Article ID 5614803, 9 pages, 2018. https://doi.org/10.1155/2018/5614803/
  33. F.A. Iannotti, C.L. Hill, A. Leo, A. Alhusaini, C. Soubrane, E. Mazzarella, E, E. Russo, B.J. Whalley, V. Di Marzo, G.J. Stephens. The non-psychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channel in vitro: potential for the treatment of neuronal hyperexcitability. ACS Chem. Neurosci. 2014 Nov 19; 5(11):1131-41.