Name                                       :  Nikhat Jamal Siddiqi
 
Nationality                              :  Indian
 
 
Address                    
Department of Internal Surgical Nursing,
 College of Nursing, King Saud University, 
 Riyadh, Saudi Arabia
 Phone: 00966-507716701
 
 
Email: nikhat@ksu.edu.sa
 
Education;
Ph. D. (Biochemistry)             :   Dr. R. M. L. Avadh University, Faizabad, India.                              Thesis entitled “Studies on oxidative stress/antioxidant defence systems and interferons during malaria infection.”
 
M. Sc. (Biochemistry)             :  University of Madras, Chennai, India.
 
 
B. Sc. (Zoology, Botany,
Chemistry)                                             University of Madras, Chennai, India.
 
 
 
Positions Held;

August 14, 2024 till present- Professor, Department of Internal Surgical Nursing,
 College of Nursing, King Saud University, 
 Riyadh, Saudi Arabia
 
Dec. 2012 – till August 2024:              Professor, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
 Earlier positions

Associate Professor, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
 Assistant Professor, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
                                               
Membership of Scientific Societies;
 
Member, British Society for Matrix Biology
Life member, Indian society for Parasitology.
Member, Indian Society of Biological Chemists
Current Research Interest;

 
Biochemistry of hydroxyproline and collagen in tissues of animals from different species, heavy metal toxicity, nanobiochemistry etc.

Important publications

Toxicology

1. Sunil Kumar Jaiswal, Vivek Kumar Gupta, Md. Dilshad Ansari, Nikhat J. Siddiqi, Bechan Sharma.  Vitamin C acts as a hepatoprotectant in carbofuran treated rat liver slices in vitro.  Toxicology Reports 4 (2017) 265–273.
2.  Al-Qahtani FA, Arafah M, Sharma B, Siddiqi NJ. Effects of alpha lipoic acid on acrylamide-induced hepatotoxicity in rats.  Cell Mol Biol (Noisy-le-grand). 2017 Jul 31;63(6):1-6. doi: 10.14715/cmb/2017.63.6.1.

3. Jaiswal SK, Siddiqi NJ, Sharma B.  Carbofuran Induced Oxidative Stress Mediated Alterations in Na+ -K+ -ATPase Activity in Rat Brain: Amelioration by Vitamin E.  J Biochem Mol Toxicol. 2014, 28 (7); 320- 327. doi: 10.1002/jbt.21568.

4. El-Ansary AK, Kotb M, Maha Zaki Rizk MZ, Siddiqi NJ.  Editorial in Prooxidant Oxidant Mechanisms in Toxicology.  BioMed Research International, 2014, Article ID 308625, 2 pages.

5. El-Ansary A,  Shaker G, Siddiqi NJ,  Al-Ayadhi LY.  Possible ameliorative effects of antioxidants on propionic acid / clindamycin – induced  neurotoxicity in Syrian hamsters.  Gut Pathogens,  2013, 5:32.

6. Loke SY, Siddiqi NJ, Alhomida AS, Kim HC, Ong WY.  Expression and localization of duodenal cytochrome b in the rat hippocampus after kainate-induced excitotoxicity.  Neuroscience, 2013 15;245:179-90.
7. Sharma RK, Upadhyay G, Siddiqi NJ, Sharma B.  Pesticides-induced biochemical alterations in occupational North Indian suburban population. Human and Experimental Toxicology, 2013, 1–15.

Collagen/Hydroxyproline

1. Siddiqi NJ, Zargar S.  Effect of quercetin on cadmium fluoride induced alterations in hydroxyproline/collagen content in mice liver.  Connect Tissue Res. 2014; 55(3):234- 238.  
2.  Siddiqi NJ.  Effect of sodium fluoride and magnesium chloride on different hydroxyproline fractions in rat liver.  Indian Journal of Biochemistry and Biophysics 2012, 49: 130-133.
3. Siddiqi NJ.  Studies on the comparative effect of sodium fluoride on collagen content in various rat organs.  African Journal of Biotechnology 2011, 10(79): 18252- 18255.

Nanotoxocology
1. .Siddiqi NJ.  Effect of gold nanoparticles on superoxide dismutase and indoleamine 2,3-dioxygenase in various rat tissues.  Indian J of Biochemistry and Biophysics, 2014,51:156-159.
2. Siddiqi NJ, M.A.K. Abdelhalim, A. K. El-Ansary, A.S. Alhomida, W.Y. Ong. Identification of potential biomarkers of gold nanoparticle toxicity in rat brains. Journal of Neuroinflammation 2012, 9:123.

Enzymology
Siddiqi NJ.  Effect of fluoride and magnesium chloride on in vivo activity of indoleamine 2, 3- dioxygenase in rat lungs.  Fluoride 2010; 43(1), 52 –56.

Carnitine
 
Siddiqi NJ, Alhomida AS, Khan HA, Ong WY.  A study on the distribution of different carnitine fractions in various tissues of bovine eye.  Cell Mol Biol (Noisy-le-grand). 2012, 22;58(1):66-70.  

Malaria
 

1. Siddiqi NJ, Alhomida AS, Dutta GP,  Pandey VC.  Antagonist effect of Chloroquine and Tumor Necrosis Factor on Hepatic Oxidative Stress and Antioxidant Defense in normal and Plasmodium yoelii nigeriensis infected mice.  In Vivo.  2002; 16: 67- 70.
2. Srivastava S, Alhomida AS, Siddiqi NJ, Pandey VC.  Changes in rodent-erythrocyte Methemoglobin reductase system produced by two malaria parasites, viz. Plasmodium yoelii nigeriensis and Plasmodium berghei.  Comparative Biochemistry and Physiology Part B 2001; 129: 725-731
3. Srivastava S, Alhomida AS, Siddiqi NJ, Pandey VC, Puri SK.  Effect of beta-arteether treatment on erythrocytic methemoglobin reductase in Plasmodium yoelii nigeriensis infected mice.  Drug and Chemical Toxicology. 2001; 24 (2): 181-190. 

Reviews
 
1.Gupta VK, Singh S, Agrawal A, Siddiqi NJ, Sharma B. Phytochemicals Mediated Remediation of Neurotoxicity Induced by Heavy Metals.  Biochem Res Int. 2015;2015:534769. doi: 10.1155/2015/534769. Epub 2015 Nov 5. Review.

2.Tanaka K, Farooqui AA, Siddiqi NJ, Alhomida AS, Ong WY.  Effects of docosahexaenoic acid on neurotransmission.  Biomolecules and Therapeutics 2012, 20 (2), 152-157.

3.Tanaka K, Siddiqi NJ, Alhomida AS, Farooqi AA, Ong WY Differential regulation of cPLA2 and iPLA2 expression in the brain.  Frontiers in Biology 2012, 7(6): 514–521.