The use of biotechnology offers a means of targeting the disease based on the basic information about the risk factor and related morbidities and pathogenesis of the disease. Various platforms like drug delivery vehicles, nanoparticle-based, carbon nanotubes, etc. are being developed and used in cancer detection. The detection techniques are handy, fast, cheap, require less human expertise, and above all, highly sensitive and reliable, and are most relevant for use in point-of-care cancer detection. My main research interest is in finding novel, non-toxic nano-conjugates that could be utilized as potential chemotherapeutic agents. I study the synthesis of novel drug conjugates using natural compounds or commercially available drugs. Additionally, I develop drug formulations using nanoparticles based on synthesized drug conjugates and evaluate the anticancer, antifungal, or antibacterial potential of these formulations. My research particularly focuses on exploring the potential of these conjugates and nano-formulations in reducing the risk of cancer. My work highlights the efficacy of these novel synthesized conjugates as sources of anti-cancer agents or adjuvants for cancer chemotherapy. Moreover, I also evaluate these conjugates and nano-formulations in targeted therapies for cancer by inhibiting the activity of pathways and preventing cancer progression. Overall, the work in cancer research highlights the critical role of nano-biotechnology, natural compounds, genetics, and targeted therapies in the field of cancer research and ultimately improves cancer diagnosis, treatment, and prevention. My research has been published in numerous high-impact journals and I have received several awards and honors for this research contributions.
areas of expertise
Award
Outstanding Research Excellence Award2019 at King Saud University, Riyadh, for a paper entitled "Inter-kingdom prediction certainty evaluation of protein subcellular localization tools: microbial pathogenesis approach for deciphering host-microbe interaction." Abdul Arif Khan, Zakir Khan, Mohd Abul Kalam, Azmat Ali Khan.
Nanobiotechnology.
RDIA Project
Azmat Ali Khan, Comparative study of a novel salicylaldiminatoPt(II) complex with a dimethylpropylene linkage and cisplatin: Unveiling perspectives on anticancer efficacy and renal toxicity Comparative study of a novel salicylaldiminatoPt (II) complex with a dimethylpropylene linkage and cisplatin: Unveiling perspectives on anticancer efficacy and renal toxicity. Research, Development, and Innovation Authority. grant number-17805-ksu-2023-KSU-B-3-1-HW. 1.200000 SR October 2024-2026.
Books
1. Rakesh K. Sindhu, Sumitra Singh, Satyendra Kumar, Azmat AliKhan. Antioxidant and Inflammatory Disorders: Molecular Mechanism and Emerging Therapeutics. Springer Press, Book 2026.
2. Azmat Ali Khan, The Arena of Sensors: A Novel Tool for Cancer Diagnosis. Published by King Saud University Press. ISBN 978-603-510-151-6, 2025.
3. Imran Zafar, Syed Umair Ahmad, Mohd Ashraf Rather, Azmat Ali Khan, Qurat Ul Ain, Arfa Safder, Sheikh Arslan. Exploration of computational frameworks of deep learning (DL) and their applications for intelligent health diagnosis and treatment management strategies. Book Chapter
4. Azmat Ali Khan*, Mumtaz Jabeen, Iftekhar Hassan, Mohammad Furqan, and Amer M. Alanazi. LIPID NANOSYSTEMS: TARGETED NANO-DELIVERY OF THERAPEUTIC AGENTS IN TREATMENT OF CANCER. Jenny Stanford Publishing Pvt. Ltd. Book Chapter 8. ISBN 978-1-003-05699-7, 2021 (eBook). Book Chapter
5. Qamar Zia, Mohammad Farzuddin, Mairaj Ahmad Ansari, Maroof Alam, Azmat Ali Khan, Iqbal Ahmad and Mohammad Owais. Novel drug delivery systems for antifungal compounds in “Combating Fungal Infections: Problems and Remedy”, eds. Ahmed I, Owais M, Shahid M and Aqil F, Springerlink, New York, USA. pp: 485-528. 2010. Book Chapter.
USA patent
Methods of making nanocomposites of metal oxide and reduced graphene oxide and use for cancer treatment. Edreese H. Alsharaeh, Faheem Ahmed, Nishat Arshi, Yasmin Mussa, Meshael Alturki, Yazeed Aldawsari, Azmat Ali Khan. Patent US20170136062 A1, Application number US. 14/943,213, Docket Number: RIPLLC032.007US1, 2017.
German Patent
Fatima Sabiha, Azmat Ali Khan, Nikhat Jamal Siddiqui. FUNCTIONALIZED NANOPARTICLE COMPOSITION COMPRISING 5-FLUOROURACIL FOR ENHANCED ANTICANCER ACTIVITY. Nr. 20 2026 101 194. IPC: A61K 31/505. 2026
UK patent
Azmat Ali Khan, Sabiha Fatima, Nikhat Jamal Siddiqi. In respect of the application of such design to: Nano-Enabled Apparatus for Localized Hepatic Tumor Treatment. International Design Classification: Version: 15-2025, Class: 24 MEDICAL AND LABORATORY EQUIPMENT Subclass: 01 APPARATUS AND EQUIPMENT FOR DOCTORS, HOSPITALS, AND LABORATORIES.
UK patent
Mudassar Shahid, Mohammad Raish, Abdul Malik, Mohd Abul Kalam, Azmat Khan, Syed Rabbani, Naushad Ali, Arpita Roy in respect of the application of such design to: LUNG CANCER DETECTING DEVICE USING BIOSENSORS International Design Classification: Version: 15-2025 Class: 24 MEDICAL AND LABORATORY EQUIPMENT Subclass: 01 APPARATUS AND EQUIPMENT FOR DOCTORS, HOSPITALS AND LABORATORIES.