An efficient and green procedure for synthesis of rhodanine derivatives by aldol-thia-Michael protocol using aqueous diethylamine medium

Fun, Assem Barakat, Abdullah M. Al-Majid, Hany J. AL-Najjar, Yahia N. Mabkhot, Hazem A. Ghabbour and Hoong-Kun . 2014

A simple, economical, and green approach to the synthesis of rhodanine derivatives using a tandem aldol condensation-thia-Michael addition process in aqueous diethylamine medium was described. The experiment protocol features simple operations, and the products were isolated in high to excellent yields (82–96%). As spontaneous precipitation always occurs at the end of the process, this leads to easy separation of the products via a simple filtration.

Publication Work Type

Master

Volume Number

Magazine \ Newspaper

RSC Advances

Pages

4909-4916