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Shaun Sabico

Associate Professor

Associate Professor and Deputy Director

كلية العلوم
Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, KSU
المنشورات
مقال فى مجلة
2014

Exposure to difenoconazole, diclofop-methyl alone and combination alters oxidative stress and biochemical parameters in albino rats

The herbicides diclofop-methyl and the fungicide difenoconazole are widely used in agriculture and may lead to serious toxicity risks. However, limited studies have been done to evaluate differences in the metabolic effects of these herbicides. Difenoconazole (10 mg/kg) and Diclofop-methyl (1 mg/kg) were orally administrated individually (Groups 1 and 2 respectively) as well as combined (G3) to rats for 28 days. In all treated groups, alanine aminotransferase (ALT) and urea were significantly higher than the control group. Plasma creatinine was also significantly higher in groups G1 and G2 than control. Significant inhibition in gamma glutamyltransferase (γGT) was observed in all treated groups, in addition to significant inhibition of plasma acetylcholinesterase enzyme (AChE) in G3 (p < 0.01). There was no effect in aspartate aminotransferase (AST) and albumin. Total plasma triiodothy-ronine (T3) hormone was significantly higher in groups G2 and G3 (p < 0.01), but significantly lower in G1 group as compared to control. Thyroxin (T4) was significantly lower in all treated groups than control. Cholesterol level was significantly lower in G3 than control, and a total protein (TP) was significantly higher in all treated groups than control. No differences were observed in glucose levels. Malondialdehyde (MDA) and superoxide dismutase (SOD), an oxidative stress biomarker, was significantly increased in all treated groups comparing to control. Sulphur containing protein (SH-protein) was significantly lower in G1 than control. No significant changes were observed for GST in all treatments. The significant differences in measured biomarkers after application of diclofop-methyl, difenoconazole individually and combined indicate that the investigated pesticides may have potentially harmful effects on humans and the surrounding environment. We suggest that larger studies be conducted to better understand the toxicity mechanisms of these pesticides.

نوع عمل المنشور
Interventional
رقم المجلد
7
رقم الانشاء
10
مجلة/صحيفة
International Journal of Clinical and Experimental Medicine 2014
الصفحات
3637-46
مزيد من المنشورات
publications

Background

بواسطة Wani K, Kumar B, Amer OE, Al-Daghri NM, Sabico S
2025
تم النشر فى:
Springer Nature
publications

Background: Fibroblast growth factor-21 (FGF21) and omentin-1 have been recognized as potent antidiabetic agents with potential hepatoprotective activity.

بواسطة Alenazi MM, Sabico S, Alnaami AM, Wani K, Hussain SD, Al-Daghri NM
2025
تم النشر فى:
Springer Nature
publications

This study investigates the 10-year atherosclerotic cardiovascular disease (ASCVD) risk in different metabolic obesity phenotypes in Saudi adults. A cohort of 5460 adults (aged 40-79) was…

بواسطة Wani K, Kumar B, Al-Daghri NM, Sabico S
2025
تم النشر فى:
Wiley