Synthesis and Biological Activity of Schiff Base Series of Valproyl, N-Valproyl Glycinyl, and N-Valproyl-4-aminobenzoyl Hydrazide Derivatives
Series of Schiff bases of valproic acid hydrazide, N-valproylglycine hydrazide and N-valproyl-4-aminobenzoyl
hydrazide derivatives were synthesized and characterized by IR, NMR (1H- and 13C-NMR) and
elemental analysis. The prepared compounds were evaluated in transgenic zebrafish embryos (Tg: flil-1: enhanced
green fluorescent protein (EGFP)) for antiangiogenic activity and in HepG2 liver carcinoma cell line
for anti cancer activity. The Schiff bases of N-valproylglycine hydrazide derivatives were most potent in term
of suppressing angiogenic blood vessels formation and anticancer activity at very low concentration, followed
by the Schiff bases of valproic acid hydrazide derivatives which exhibited moderate activity, while the Schiff
bases of N-valproyl-4-aminobenzoyl hydrazide derivatives, ethyl 4-(2-propylpentanamido)benzoate (VABE)
and N-(4-(hydrazinecarbonyl)phenyl)-2-propylpentanamide (VABH) in contrast exhibited pro-angiogenic
activity and weaker anticancer activity which mean that these derivatives targeted a common signaling pathway
in term of affecting the blood vessels formation.
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