Ultrasonic Irradiation: Synthesis, Characterization, and Preliminary Antimicrobial Activity of Novel Series of 4,6-Disubstituted-1,3,5-triazine Containing Hydrazone Derivatives
El-Faham, Hessa H. Al-Rasheed, Monirah Al Alshaikh, JamalM. Khaled, Nayif S. Alharbi and Ayman . 2016
Novel series of 4,6-disubstituted-1,3,5-triazines containing hydrazone derivativeswere synthesized employing ultrasonic irradiation and conventional heating.The ultrasonication gave the target products in higher yields and purity in shorter reaction time compared with the conventional method. IR, NMR (1H and 13C), elemental analysis, and LC-MS confirmed the structures of the new products.The antimicrobial and antifungal activities were evaluated for all the prepared compounds against some selected Grampositive and Gram-negative bacterial strains. The results showed that only two compounds 7i (pyridine derivative) and 7k (4-chlorobenzaldehyde derivative) displayed biological activity against some Gram-positive and Gram-negative bacteria, while the rest of the tested compounds did not display any antifungal activity.
Abstract
Cancer is a broad category of disease that can affect virtually any organ or tissue in the body when abnormal cells grow
uncontrollably, invade surrounding tissue, and/or spread…
3-(Adamantan-1-yl)-4-(4-fluorophenyl)-1-f[4-(2-methyoxyphenyl)piprazin-
1yl]-methylg-4,5-dihydro-1H-1,2,4-triazole-5-thione (AFT) was synthesized
and spectroscopic investigations have been…
Nowadays, reverse osmosis is the most widely utilized strategy in membrane technology due to its continuous improvement. Recent studies have highlighted the importance of the surface…