Green electrospining of hydroxypropyl cellulose nanofibres for drug delivery applications
Electrospun nanofibers mats are green synthesized using hydroxypropyl cellulose (HPC) individually or in conjugation with either poly(vinyl alcohol) (PVA) or Polyvinylpyrrolidone (PVP) to enhance the mechanical properties of the nanofibers mats. Desirable attributes of the as–obtained nanofibers mats are manifested via using SEM, FT-IR, TGA and conventional tools for mechanical and physical properties. The obtained data from SEM images demonstrated that the diclofenac sodium (DS) loaded nanofibers mats did not provide significant change of the morphological structure to the mats. In addition the thermal stability and the visual and mechanical properties of PVA or PVP was dramatically enhanced with the addition of HPC. The in vitro sustained release of DS drug was controlled when loaded into electrospun nanofibers of HPC with either PVA or PVP
Fungal biofilms have caused several medical problems, resulting in significant morbidity and mortality as well as poor response to antifungal drugs.
Cellulose has been one of the most widespread materials due to its renewability, excellent mechanical properties, biodegradability, high absorption ability, biocompatibility and cheapness.
The burst release of drug is a problem associated with the use of common blending electrospinning. This problem can be avoided via fabrication of core–shell nanofibers where drug can be coated…