المنشورات
مقال فى مجلة
2014
Directed Lithiation of N'-(2-(4-Methoxyphenyl)ethyl)-N,N-dimethylurea and tert-Butyl (2-(4-Methoxyphenyl)ethyl)carbamate
Alshammari, Mohammed B. . 2014
N'-(2-(4-Methoxyphenyl)ethyl)-N,N-dimethylurea and tert-butyl (2-(4-methoxyphenyl)ethyl)carbamate are doubly lithiated on the nitrogen and ortho- to the directing metalating group at -20 to 0 °C with three mole equivalents of n-BuLi in anhydrous THF. Reactions of the dilithium reagents produced in situ with various electrophiles give high yields of the corresponding substituted products. In the case of the urea, side-products due to lithiation and substitution on one of the methyl groups of the urea unit are obtained in low yields (0-17%).
نوع عمل المنشور
Research
رقم المجلد
46
رقم الانشاء
3
مجلة/صحيفة
Synthesis
الصفحات
394-402
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