The antidiabetic action of camel milk in experimental type 2 diabetes mellitus: an overview on incretin hormones, insulin resistance and inflammatory cytokines.
AA., Korish . 2014
Abstract
Several folklore stories and recent studies accredited the aptitude of camel milk (CMK) as a hyperglycemic agent in diabetic patients and experimental animals. However, the mechanism(s) by which CMK can influence glucose homeostasis is yet unclear. The current study investigated the changes in the glucose homeostatic parameters, the incretin hormones, and the inflammatory cytokines in CMK-treated diabetic animals. Diabetes was induced by intraperitoneal streptozotocin in 40 male Wister rats divided into (D & D-CMK) groups. A forty healthy control rats constitute the (C & C-CMK) groups. Camel milk was administered to the C-CKM and D-CKM groups for 8 weeks, the other groups received no treatment. The changes in glucagon like peptide-1 (GLP-1), glucose dependent insulinotropic peptide (GIP), glucose tolerance, insulin level, insulin resistance, TNF-α, TGF-β1, lipid profile, atherogenic index, and body weight were investigated. The untreated diabetic animals showed hyperglycemia, insulin resistance, hyperlipidemia, elevated atherogenic index, high serum incretins [GLP-1 and GIP], TNF-α, and TGF-β1 levels, and weight loss as compared with the control group. Camel milk treatment to the D-CMK group was associated with significant hypoglycemia, hypolipidemia, decreased HOMA-IR, recovery of insulin secretion, weight gain, and no mortality during the study. Additionally, CMK inhibits the diabetes- induced elevation in incretin hormones, TNF-α and TGF-β1 levels. Increased insulin secretion, decreased HOMA-IR, modulation of the secretion and / or action of incretins, and the anti-inflammatory effect of CMK are anticipated mechanisms to the anti-diabetic effect and propose it to be a valuable adjuvant anti-diabetic therapy.
Keywords: Camel milk, diabetes mellitus, insulin resistance, incretin hormones, inflammatory cytokines
Abstract
ABSTRACT
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