السيرة الذاتية
السيرة الذاتية
مختصر السيرة الذاتية
CURRICULUM VITAE
Personal Data
Name : Abir Ghanouchi-Ben Bacha
Sex and Marital Status : Female, Married with 3 children
Nationality : Tunisian
Occupation : Professor of Biochemistry
Languages : Arabic, French and English
Research Interest : Protein chemistry and Autism biomarkers
Contact Information
Personal telephone : 00966504784639
Office address : Department of Biochemistry, King Saud University,
PO Box 22452, Riyadh-11495, Saudi Arabia
Office phone : 00966-1-8055129
Emails : aalghanouchi@ksu.edu.sa
Diplomas:
- 2013: Academic Habilitation Degree, HDR Biological Engineering (ENIS - Sfax
University)
- 2007: PhD degree in biological engineering (ENIS - Sfax University)
(Title of Thesis: Ostrich digestive lipolytic enzymes: a comparative study with mammal enzymes)
- 2003: Master degree in biological engeneering (ENIS - Sfax University)
(Title: Purification and biochemical characterization of ostrich pancreatic lipase)
- 2000: Science degree in biological sciences in (FSS - Sfax University)
Work experience:
Teaching
April 2020 – Till date :Professor at King Saud University, Science College, Biochemistry department
2013 – 2020 : Associate Professor at King Saud University, Science College, Biochemistry department
2009 – 2013 : Assistant Professor at King Saud University, Science College, Biochemistry department
2007 – 2009 : Assistant Professor at faculty of sciences of Sfax
2003 – 2006 : Assistant at the faculty of sciences of Sfax
Teaching Activities:
Teaching many undergraduate and postgraduate courses
Supervision of 2 PhD and 11 Master Thesis
Research Grants:
- Principal investigator of a Research Project Nº RGP-VPP-070 "Biochemical and Structural Characterization of secreted phospholipases A2" financed by King Saud University, Kingdom of Saudi Arabia, (4/2011 - 4/2012).
- Co-investigator in a Research Project Nº RGP-VPP-005 "Treatment and preventive strategies of autism disease" financed by King Saud University, Kingdom of Saudi Arabia, (4/2011 - 4/2012).
- Researcher in a Research Project “Molecular detection of viruses and bacteria in treated waste water and in well water in the governorate of Al Riyadh, Saudi Arabia” Nº 12-ENV2528-02 supported by King Abdulaziz City for Science and Technology (KACST), (4/2014 - 4/2016).
- Co-investigator in a Research Project Nº RG-1435-083 financed by King Saud University, Kingdom of Saudi Arabia, (2/2017 - 2/2019).
- Co-investigator in a Research Project Nº RG-1441-471 financed by King Saud University, Kingdom of Saudi Arabia, (2/2020 - 2/2021).
- Co-investigator in a Research Project Nº RGP-070 financed by King Saud University, Kingdom of Saudi Arabia, (5/2020 - 5/2023).
- Principal investigator in a Research Project Nº IFKSUOR3-230 financed by King Saud University, Kingdom of Saudi Arabia, (5/2023 - 5/2024).
Publications
1. El-Sayed N.N.E; Al-Otaibi T.M.; Barakat A.; Almarhoon Z.M.; Hassan M. Z.; M.I. Al-Zaben; Krayem N.; Masand V.H.; Ben Bacha A. Synthesis and Biological Evaluation of Some New 3-Aryl-2-thioxo-2,3-dihydroquinazolin-4(1H)-ones and 3- Aryl-2-(benzylthio) quinazolin-4(3H)-ones as Antioxidants, COX-2, LDHA, α-Glucosidase and α-Amylase Inhibitors, as well as Anti-colon Carcinoma and Apoptosis. Accepted in pharmaceuticals.
2. Alonazi, M.; Krayem, N.; Alharbi, M.G.; Khayyat, A.I.A.; Alanazi, H.; Horchani, H.; Ben Bacha, A. Functional Characterization and Anti-Tumor Effect of a Novel Group II Secreted Phospholipase A2 from Snake Venom of Saudi Cerastes cerates gasperetti. Molecules 2023, 28, 6517. https://doi.org/10.3390/ molecules28186517
3. Alonazi M, Al-Diahan SK, Alzahrani ZRA, Ben Bacha A. Combined immobilized lipases for effective biodiesel production from spent coffee grounds. Saudi J Biol Sci. 2023 Sep;30(9):103772. doi: 10.1016/j.sjbs.2023.103772. Epub 2023 Aug 10. PMID: 37663395; PMCID: PMC10470282.
4. Kamalmaz N, Ben Bacha A, Alonazi M, Albasher G, Khayyat AIA, El-Ansary A. Unveiling sex-based differences in developing propionic acid-induced features in mice as a rodent model of ASD. PeerJ. 2023 Jun 13;11:e15488. doi: 10.7717/peerj.15488. PMID: 37334116; PMCID: PMC10274690.
5. Alonazi M, Ben Bacha A, Alharbi MG, Khayyat AIA, Al-Ayadhi L, El-Ansary A. Bee Pollen and Probiotics' Potential to Protect and Treat Intestinal Permeability in Propionic Acid-Induced Rodent Model of Autism. Metabolites. 2023 Apr 12;13(4):548. doi: 10.3390/metabo13040548. PMID: 37110206; PMCID: PMC10143803.
6. Nafaa M, Rizk SM, Aly TA-GA, Rashed MA-S, Abd El-Moneim D, Ben Bacha A, Alonazi M, Magdy M. Screening and Identification of the Rhizosphere Fungal Communities Associated with Land Reclamation in Egypt. Agriculture. 2023; 13(1):215. https://doi.org/10.3390/agriculture13010215
7. Alsubaiei SRM, Alfawaz HA, Almubarak AY, Alabdali NA, Ben Bacha A, El-Ansary A. Independent and Combined Effects of Probiotics and Prebiotics as Supplements or Food-Rich Diets on a Propionic-Acid-Induced Rodent Model of Autism Spectrum Disorder. Metabolites. 2022 Dec 29;13(1):50. doi: 10.3390/metabo13010050. PMID: 36676975; PMCID: PMC9863040.
8. Ben Bacha, A.; Alonazi, M.; Alharbi, M.G.; Horchani, H.; Ben Abdelmalek, I. Biodiesel Production by Single and Mixed Immobilized Lipases Using Waste Cooking Oil. Molecules 2022, 27, 8736. ht
9. Moutaouakil, M.; Tighadouini, S.; M. Almarhoon, Z.; I. Al-Zaben, M.; Ben Bacha, A.; H. Masand, V.; Jamaleddine, J.; Saddik, R. Quinoline Derivatives with Different Functional Groups: Evaluation of Their Catecholase Activity. Catalysts 2022, 12, 1468.
10. Ben Bacha, A., Alonazi, M., Alanazi, H., Alharbi, M. G., Jallouli, R., & Karray, A. (2022). Biochemical Study of Bacillus stearothermophilus Immobilized Lipase for Oily Wastewater Treatment. Processes, 10(11), 2220.
11. Alonazi M, Ben Bacha A, Al Suhaibani A, Almnaizel AT, Aloudah HS, El-Ansary A. Psychobiotics improve propionic acid-induced neuroinflammation in juvenile rats, rodent model of autism. Transl Neurosci. 2022 Sep 8;13(1):292-300.
12. Saddik R, Hammoudan I, Tighadouini S, Roby O, Radi S, Al-Zaben MI, Ben Bacha A, Masand VH, Almarhoon ZM. Mesoporous Silica Modified with 2-Phenylimidazo[1,2-a] pyridine-3-carbaldehyde as an Effective Adsorbent for Cu(II) from Aqueous Solutions: A Combined Experimental and Theoretical Study. Molecules. 2022 Aug 13;27(16):5168.
13. El-Sayed NNE, Zaki MEA, Al-Hussain SA, Ben Bacha A, Berredjem M, Masand VH, Almarhoon ZM, Omar HS. Synthesis and Evaluation of Some New 4H-Pyran Derivatives as Antioxidant, Antibacterial and Anti-HCT-116 Cells of CRC, with Molecular Docking, Antiproliferative, Apoptotic and ADME Investigations. Pharmaceuticals (Basel). 2022 Jul 19;15(7):891.
14. Al-Nemari, R., Ben Bacha, A., Al-Senaidy, A., Almutairi, M.H., Arafah, M., Al-Saran, H., Abutaha, N., & Semlali, A. Cytotoxic effects of Annona squamosa leaves against breast cancer cells via apoptotic signaling proteins. Journal of King Saud University - Science. 2022 Jun; 34 (4): 102013
15. Karray A, Alonazi M, Jallouli R, Alanazi H, Ben Bacha A. A Proteinaceous Alpha-Amylase Inhibitor from Moringa Oleifera Leaf Extract: Purification, Characterization, and Insecticide Effects against C. maculates Insect Larvae. Molecules. 2022 Jun 30;27(13):4222.
16. El-Sayed NNE, Almaneai NM, Ben Bacha A, El-Ashrey MK, Al-Zaben MI, Almarhoon ZM. Biological Evaluation, Molecular Docking Analyses, and ADME Profiling of Certain New Quinazolinones as Anti-colorectal Agents. ACS Omega. 2022 May 23;7(22):18443-18458.
17. Alonazi M, Karray A, Jallouli R, Ben Bacha A. Biochemical, Kinetic and Biological Properties of Group V Phospholipase A2 from Dromedary. Molecules. 2022 May 26;27(11):3437.
18. Malhi DS, Sohal HS, Singh K, Almarhoon ZM, Ben Bacha A, Al-Zaben MI. Highly Efficient Electrocarboxylation Method to Synthesize Novel Acid Derivatives of 1,4-Dihydropyridines and to Study Their Antimicrobial Activity. ACS Omega. 2022 Apr 28;7(18):16055-16062.
19. Almarhoon, Z, Al-Zaben, M, Ben Bacha A, Haukka, M, El-Faham, A & Soliman, S. (2021). Synthesis, X-ray Structure, Conformational Analysis, and DFT Studies of a Giant s-Triazine bis-Schiff Base. Crystals. 11. 1418. 10.3390/cryst11111418.
20. Kamal S, Derbala HA, Alterary SS, Ben Bacha A, Alonazi M, El-Ashrey MK, Eid El-Sayed NN. Synthesis, Biological, and Molecular Docking Studies on 4,5,6,7-Tetrahydrobenzo[b]thiophene Derivatives and Their Nanoparticles Targeting Colorectal Cancer. ACS Omega. 2021 Oct 25;6(43):28992-29008.
21. Ben Bacha A, Al-Orf N, Alonazi M, Bhat RS, El-Ansary A. The anti-inflammatory and antiapoptotic effects of probiotic on induced neurotoxicity in juvenile hamsters. Food Sci Nutr. 2021 Jul 13;9(9):4874-4882.
22. Al Suhaibani A, Ben Bacha A, Alonazi M, Shafi Bhat R.S, El-Ansary Afaf, Testing the combined effects of probiotics and prebiotics against neurotoxic effects of propionic acid orally administered to rat pups. Food Sci Nutr. 2021;00:1–12.
23. El-Sayed NNE, Al-Otaibi TM, Alonazi M, Masand VH, Barakat A, Almarhoon ZM, Ben Bacha A. Synthesis and Characterization of Some New Quinoxalin-2(1H)one and 2-Methyl-3H-quinazolin-4-one Derivatives Targeting the Onset and Progression of CRC with SRA, Molecular Docking, and ADMET Analyses. Molecules. 2021 May 23;26(11):3121.
24. Alonazi, M.; Karray, A.; Badjah-Hadj-Ahmed, A.Y.; Ben Bacha, A. Al-pha Amylase from Bacillus pacificusAssociated with Brown Algae Turbina-ria ornata: Cultural Conditions, Pu-rification, and Biochemical Character-ization. Processes 2021, 9, 16.
25. Karray A, Alonazi M, Horchani H, Ben Bacha A. A Novel Thermostable and Alkaline Protease Produced from Bacillus stearothermophilus Isolated from Olive Oil Mill Sols Suitable to Industrial Biotechnology. Molecules. 2021 Feb 20;26(4):1139.
26. Alonazi MA, Jemel I, Moubayed N, Alwhibi M, El-Sayed NNE, Ben Bacha A. Evaluation of the in vitro anti-inflammatory and cytotoxic potential of ethanolic and aqueous extracts of Origanum syriacum and Salvia lanigera leaves. Environ Sci Pollut Res Int. 2021 Apr; 28(16):19890-19900.
27. Alonazi M, Horchani H, Alwhibi M, Ben Bacha A. Cytotoxic, Antioxidant, and Metabolic Enzyme Inhibitory Activities of Euphorbia cyparissias Extracts. Oxid Med Cell Longev. 2020 Oct 29;2020:9835167.
28. Abid, I.; Jemel, I.; Alonazi, M.; Ben Bacha, A. A New Group II Phospholipase A2 from Walterinnesia aegyptia Venom with Antimicrobial, Antifungal, and Cytotoxic Potential. Processes 2020, 8, 1560.
29. El-Ansary A, Hassan WM, Daghestani M, Al-Ayadhi L, Ben Bacha A. Preliminary evaluation of a novel nine-biomarker profile for the prediction of autism spectrum disorder. PLoS One. 2020 Jan 16;15(1):e0227626.
30. Ben Bacha A, Norah AO, Al-Osaimi M, Harrath AH, Mansour L, El-Ansary A. The therapeutic and protective effects of bee pollen against prenatal methylmercury induced neurotoxicity in rat pups. Metab Brain Dis. 2020 Jan;35(1):215-224.
31. Al-Nemari R, Al-Senaidy A, Semlali A, Ismael M, Badjah-Hadj-Ahmed AY, Ben Bacha A. GC-MS profiling and assessment of antioxidant, antibacterial, and anticancer properties of extracts of Annona squamosa L. leaves. BMC Complement Med Ther. 2020 Oct 6;20(1):296.
32. Karray A, Alonazi M, Smaoui S, Michaud P, Soliman D, Ben Bacha A. Purification and Biochemical Characterization of a New Protease Inhibitor from Conyza dioscoridis with Antimicrobial, Antifungal and Cytotoxic Effects. Molecules. 2020 Nov 20;25(22):5452.
33. Abid, I.; Jemel, I.; Alonazi, M.; Ben Bacha, A. A New Group II Phospholipase A2 from Walterinnesia aegyptia Venom with Antimicrobial, Antifungal, and Cytotoxic Potential. Processes 2020, 8, 1560.
34. El-Ansary A, Hassan WM, Daghestani M, Al-Ayadhi L, Ben Bacha A. Preliminary evaluation of a novel nine-biomarker profile for the prediction of autism spectrum disorder. PLoS One. 2020 Jan 16;15(1):e0227626. doi: 10.1371/journal.pone.0227626. PMID: 31945130; PMCID: PMC6964874.
35. Ben Bacha A, Norah AO, Al-Osaimi M, Harrath AH, Mansour L, El-Ansary A. The therapeutic and protective effects of bee pollen against prenatal methylmercury induced neurotoxicity in rat pups. Metab Brain Dis. 2020 Jan;35(1):215-224. doi: 10.1007/s11011-019-00496-z. Epub 2019 Oct 17. PMID: 31625070.
36. Al-Nemari R, Al-Senaidy A, Semlali A, Ismael M, Badjah-Hadj-Ahmed AY, Ben Bacha A. GC-MS profiling and assessment of antioxidant, antibacterial, and anticancer properties of extracts of Annona squamosa L. leaves. BMC Complement Med Ther. 2020 Oct 6;20(1):296. doi: 10.1186/s12906-020-03029-9. PMID: 33023568; PMCID: PMC7541211.
37. Karray A, Alonazi M, Smaoui S, Michaud P, Soliman D, Ben Bacha A. Purification and Biochemical Characterization of a New Protease Inhibitor from Conyza dioscoridis with Antimicrobial, Antifungal and Cytotoxic Effects. Molecules. 2020 Nov 20;25(22):5452. doi: 10.3390/molecules25225452. PMID: 33233753; PMCID: PMC7699837.
38. Bhat RS, El Gezeery A, Ben Bacha A, Alonazi MA, Alsuhaibani LS, and El-Ansary A. Prenatal exposure to the fluoride containing psychiatric drug fluoxetine and anti-oxidative alterations in the neonatal rat brain. BIOCELL 2019, 43(2): 65-71.
39. Al-Nuwaysir H, Moubayed N, Al-Othman M, Ben Bacha A, and Abid I. Molecular detection of Escherichia coli in Wadi Hanifa, Saudi Arabia. Biomedical Research (2019) Volume 30, Issue 2.
40. Nahed N. E. El-Sayed, Norah M. Almaneai, Saied M. Soliman, Abir Ben Bacha and Hazem A. Ghabbour. Synthesis, Structural Investigation, Antiphospholipases, Antiproteases and antimicrobial activities of 2-(4-hydroxy-3-methoxy-benzylidene)-6-methoxy-3,4-dihydro-2H-naphthalen-1-one and 4‑(4‑hydroxy-3-methoxy-phenyl)-8-methoxy-3,4,5,6-tetrahydro-1H-benzo[h] quinazoline-2-thione. Journal of the Chemical Society of Pakistan. 2019 Dec; 41 (06).
41. El-Sayed NNE, Almaneai NM, Ben Bacha A, Al-Obeed O, Ahmad R, Abdulla M, Alafeefy AM. Synthesis and evaluation of anticancer, antiphospholipases, antiproteases, and antimetabolic syndrome activities of some 3H-quinazolin-4-one derivatives. J Enzyme Inhib Med Chem. 2019 Dec; 34(1):672-683. doi: 10.1080/14756366.2019.1574780.
42. A. El-Ansary, N. Zayed, M.H. Daghestani1, A. Ben Bacha. Metabolic and Immune Aspects of Sex Differences in Autism. Recent Advances in Autism Chapter 2. 2019
43. Ben Bacha A, Jemel I, Shafi Bhat R, and Alonazi MA. Inhibitory effects of various solvent extracts from R. frangula leaves on some inflammatory and metabolic enzymes. Cell Mol Biol (Noisy-le-grand). 2018 Oct 30; 64 (13):55-62.
44. Al-Orf N, El-Ansary A, Bjørklund G, Moubayed N, Bhat RS, Ben Bacha A. Therapeutic effects of probiotics on neurotoxicity induced by clindamycin and propionic acid in juvenile hamsters. Metab Brain Dis. 2018 Dec; 33 (6):1811-1820.
45. Al-Osaimi M, El-Ansary A, Al-Daihan S, Bhat RS, Ben Bacha A. Therapeutic and Protective Potency of Bee Pollen Against Neurotoxic Effects Induced by Prenatal Exposure of Rats to Methyl Mercury. J Mol Neurosci. 2018 Jul;65(3):327-335. doi: 10.1007/s12031-018-1107-1.
46. El-Ansary A, Bjørklund G, Khemakhem AM, Al-Ayadhi L, Chirumbolo S, Ben Bacha A. Metabolism-Associated Markers and Childhood Autism Rating Scales (CARS) as a Measure of Autism Severity. J Mol Neurosci. 2018 Jul;65(3):265-276. doi: 10.1007/s12031-018-1091-5. Epub 2018 Jun 22.
47. Ben Bacha A, Alonazi MA, Elshikh MS, Karray A. A novel bactericidal homodimeric PLA2 group-I from Walterinnesia aegyptia venom. Int J Biol Macromol. 2018; 117:1140-1146.
48. Ben Bacha A and Abid I. Hydrolysis of oils in the Wadi Hanifah River in Saudi Arabia by free and immobilized Staphylococcus aureus ALA1 lipase. Environmental Progress & Sustainable Energy. 2018; DOI 10.1002/ep.13000
49. El-Ansary A, Ben Bacha A, Bjørklund G, Al-Orf N, Bhat RS, Moubayed N, Abed K. Probiotic treatment reduces the autistic- like excitation/inhibition imbalance in juvenilehamsters induced by orally administered propionic acid and clindamycin. Metab Brain Dis. 2018 Aug; 33(4):1155-1164.
50. Al-Daihan S, Ben Bacha A, El-Ansary A, Bhat RS. PRENATAL BEE POLLEN TREATMENT IMPROVES THE NEUROTOXICITY IN NEW BORN RATS DURING CHRONIC FLUORIDES EXPOSURE IN RELATION TO PROPIONIC ACID -INDUCED RODENT MODELS OF AUTISM. Accepted in Fluoride, 2018
51. Al-Daihan S, Ben Bacha A, Al-Dbass AM, Alonazi MA. and Shafi Bhat R. High-fat diet stimulates the gut pathogenic microbiota and maintains hepatic injury in antibiotic-treated rats. Cell Mol Biol (Noisy-le-grand). 2018 Jan 31;64(1):103-106.
52. Al-Bagmi MS, Khan MS, Ismail MH, Al-Senaidy AM, Ben Bacha A, Husain FM, Alamery SF. An efficient methodology for the purification of date palm peroxidase: Stability comparison with Horseradish Peroxidase (HRP). Saudi Journal of Biological Sciences. Available online 12 April 2018. Volume 26, Issue 2, February 2019, Pages 301-307
53. Alasmary FAS, Alnahdi FS, Ben Bacha A, El-Araby AM, Moubayed N, Alafeefy AM, El-Araby ME. New quinoxalinone inhibitors targeting secreted phospholipase A2 and α-glucosidase. J Enzyme Inhib Med Chem. 2017 Dec;32(1):1143-1151.
54. Ben Abdelmalek I., Alzaiydi A. and Ben Bacha A. THE BIOREFINING OF SAUDI ARABIAN WASTE DATE: AN ENVIRONMENTAL PROMISING ALTERNATIVE TO PETROCHEMISTRY. Int. J. Adv. Res. 5(4), 1250-1261
55. Khemakhem A., Frye RE., El-Ansary A., Al-Ayadhi A. and Ben Bacha A. Novel biomarkers of metabolic dysfunction is autism spectrum disorder: potential for biological diagnostic markers. Metab Brain Dis. 2017 Dec;32(6):1983-1997. doi: 10.1007/s11011-017-0085-2.
56. Moubayed NM. and Ben Bacha A. PLA2 inhibitory, antioxidant and antibacterial properties of various solvent extracts from R. frangula leaves Biomedical Research 2017; 28 (4): 1844-1850.
57. Ben Bacha A. Jemel I., Moubayed NM. and Ben Abdelmalek I. Purification and characterization of a newly serine protease inhibitor from Rhamnus frangula with potential for use as therapeutic drug. 3 Biotech (2017) 7:148.
58. El-Sayed NN, Alafeefy AM, Bakht MA, Masand VH, Aldalbahi A, Chen N, Fan C, Ben Bacha A. Synthesis, Antiphospholipase A2, Antiprotease, Antibacterial Evaluation and Molecular Docking Analysis of Certain Novel Hydrazones. Molecules. 2016 Dec 2; 21(12).
59. Ben Bacha A, Al-Assaf A., Moubayed NM. and Abid I. A novel high thermo-alkaline Staphylococcus aureus lipase: an ideal choice for application in detergent formulations. Saudi Journal of Biological science 2018; 25: 409–417
60. Ben Bacha A., Moubayed NM. and Al-Assaf A. An organic solvent-stable lipase from a newly isolated staphylococcus aureus ALA1 strain with potential for use as an industrial biocatalyst. Biotechnol Appl Biochem. 2016; 63(3):378-90.
61. Ben Bacha A., Moubayed NM. and Abid I. Thermostable alkaline and detergent-tolerant lipase from a newly isolated thermophilic Bacillus stearothermophilus. Indian J Biochem Biophys. 2015; 52(2): 179-88.
62. El-Meligy RM., Awaad AS., Soliman GA., Ben Bacha A., Alafeefy AM., and Kenawy SA Prophylactic and Curative Anti-ulcerative colitis activity and the possible mechanisms of action of some desert plants. J Enzyme Inhib Med Chem. 2015; 30(2):250-8.
63. Alafeefy AM., Awaad AS., Abdel-Aziz HA., El-Meligy RM., Zain ME., Al-Outhman MR. and Ben Bacha A. Synthesis and biological evaluation of certain 3-substituted benzylideneamino-2-(4-nitrophenyl)quinazolin-4(3H)-one derivatives. J Enzyme Inhib Med Chem. 2015; 30(2):270-6.
64. Ben Bacha A Anti-Bactericidal Properties of Stingray Dasyatis pastinaca Groups V, IIA, and IB Phospholipases A2: A Comparative Study. Appl Biochem Biotechnol. 2014;174(4):1520-34.
65. Ben Bacha A., Abid I., Horchani H., Mejdoub H. Enzymatic properties of stingray Dasyatis pastinaca group V, IIA and IB phospholipases A2: A comparative study. International Journal of Biological Macromolecules 2013; 62: 537-542.
66. El-Ansary A, Al-Daihan S, Bacha AB, Kotb M. Toxicity of novel nanosized formulations used in medicine. Methods Mol Biol. 2013;1028:47-74
67. Ben Bacha A., Al-Daihan S., Mejdoub H. Purification and characterization of a new organic-solvent-tolerant SPLA2-IIA from common stingray intestine. Indian Journal of Biochemistry & Biophysics 2013; 50: 186-195.
68. Ben Bacha A., Al-Daihan S., Mejdoub H. Purification, characterization and antibacterial activities of of phospholipase A2 from the dromedary intestine. International Journal of Biological Macromolecules 2013; 57: 156– 164.
69. Ben Bacha A., Abid I. Secretory Phospholipase A(2) in Dromedary Tears: a Host Defense Against Staphylococci and Other Gram-Positive Bacteria. Applied Biochemistry and Biotechnology 2013; 169(6):1858-69.
70. El-Ansary A.K., Al-Daihan S., Ben Bacha A., Shaker G.H., Al-Ayadhi L. Comparative study on the protective effect of Carnosine and Carnitine against pro-inflammatory/ pro-oxidant effects of Clindamycin and Propionic acid administrations to hamsters. African Journal of Microbiology Research 2013; 7(2):103-114.
71. Ben Bacha A., Abid I., Horchani H. Antibacterial properties of intestinal phospholipase A2 from the common stingray Dasyatis pastinaca. Applied Biochemistry and Biotechnology 2012; 168:1277-1287.
72. El-Ansary A.K., Ben Bacha A., Kotb M. Etiology of autistic features: the persisting neurotoxic effects of propionic acid. Journal of Neuroinflammation 2012; 9: 74.
73. Hammami I., Jaouadi B., Ben Bacha A., Rebai A., Bejar S., Nesme X., Rhouma A. Bacillus subtilisbacteriocin Bac 14B with a broad inhibitory spectrum: Purification, amino acid sequence analysis, and physicochemical characterization. Biotechnology and Bioprocess Engineering 2012; 17 (1): 41-49.
74. Al-Ayadhi L.Y., Ben Bacha A., Kotb M., El-Ansary A.K. A novel study on amyloid beta peptide 40, 42 and 40/42 ratio in Saudi autistics. Behavioral and Brain Function 2012, 8(1): 4.
75. Ben Bacha A., Mejdoub H. Purification and biochemical characterization of an organic-solvent-tolerant thioredoxin from dromedary pancreas. Protein Journal 2012; 31(1): 1-7.
76. El-Ansary A.K., Ben Bacha A., Al-Ayadhi LY. Proinflammatory and proapoptotic markers in relation to mono and di-cations in plasma of autistic patients from Saudi Arabia. J Neuroinflammation. 2011 Oct 15;8:142.
77. Ben Bacha A., Mejdoub H. Proteolytic cleavage of stingray phospholipase A2: Isolation and biochemical characterization of an active N-terminal form. Lipids in Health and Disease 2011; 10: 124.
78. El-Ansary A.K., Ben Bacha A., Al- Ayadhi L.Y. Relationship between chronic lead toxicity and plasma neurotransmitters in autistic patients from Saudi Arabia. Clinical Biochemistry 2011; 44(13): 1116-20.
79. El-Ansary A.K., Ben Bacha A., Al- Ayadhi L.Y. Impaired plasma phospholipids and relative amounts of essential polyunsaturated fatty acids in autistic patients from Saudi Arabia. Lipids Health Disease 2011; 10 (1): 63.
80. El-Ansary A.K., Ben Bacha A., Al- Ayadhi L.Y. Plasma fatty acids as diagnostic markers in Saudi autistics. Lipids in Health and Disease 2011; 10 (1): 62
81. Ben Bacha A., Karray A., Daoud L., Bouchaala E., Bou Ali M., Gargouri Y., Ben Ali Y. Biochemical properties of pancreatic colipase from the common stingray Dasyatis pastinaca. Lipids in Health and Disease 2011; 10: 69. (IF: 2.170)
82. Ben Bacha A., Karray A., Bouchaala E., Gargouri Y., Ben Ali Y Purification and biochemical characterization of pancreatic phospholipase A2 from the common stingray Dasyatis pastinaca. Lipids in Health and Disease 2011; 10(1): 32.
83. Damak N., Hadj-Taieb N., Bonnin E., Ben Bacha A., Gargouri A. Purification and biochemical characterization of a novel thermoactive fungal pectate lyase from Penicillium occitanis. Process Biochemistry 2011; 46 (4): 888-893.
84. Cherif S., Ben Bacha A., Ben Ali Y., Horchani H., Rekik W., Gargouri.Y. Crab digestive phospholipase: a new invertebrate member. Bioresource Technology 2010; 101 (1): 366-71.
85. Zarai Z., Ben Bacha A., Horchani H., Bezzine S., Gargouri Y., Mejdoub H. A novel marine hepatopancreatic phospholipase A2 with digestive and toxic activities. Archives of Biochemistry and Biophysics 2010; 494(2): 121-129.
86. Miled N., Fikha F., Ben Bacha A., Mejdoub H. Gargouri Y. Structural homologies, importance for catalysis and lipid binding of the N-terminal Peptide of a fungal and a pancreatic lipase. Protein Peptide Letters 2010; 17(2): 254-259.
87. Blibech M., Ghorbel R.E., Fakhfakh I., Ntarima P., Piens K., Ben Bacha A., Ellouz Chaabouni S. Purification and characterization of a low molecular weight of beta-mannanase from Penicillium occitanis Pol6. Applied Biochemistry and Biotechnology 2010; 160(4):1227-40.
88. Zouari N., Elgharb F., Fakhfakh N., Ben Bacha A., Gargouri Y., Miled N. Effect of dietary vitamin E supplementation on lipid and colour stability of chicken thigh meat. African Journal of Biotechnology 2010; 9(15): 2276-2283.
89. Karray A., Frikha F., Ben Bacha A., Ben Ali Y., Gargouri Y., Bezzine S. Purification, biochemical and structural characterization of turkey pancreatic phospholipase A2. FEBS Journal 2009; 276: 4545-4554.
90. Ben Bacha A., Gargouri Y., Bezzine S., Mosbah H., Mejdoub H. A bird pancreatic phospholipase A2: Purification and biochemical characterization. Journal of Chromatography B 2007; 857(1):108-114.
91. Ben Bacha A., Fendri A., Gargouri Y., Mejdoub H., Miled N. Proteolytic cleavage of ostrich and turkey pancreatic lipases: Production of a fully active N-terminal domain. Pancreas 2007; 35: 55-61.
92. Fendri A., Frikha F., Miled N., Ben Bacha A., Gargouri Y. Modulating the activity of avian pancreatic lipases by the alkyl chain reacting with an accessible Sulfhydryl group. Biochemical and Biophysical Research Communications 360 (2007) 765-771.
93. Ben Bacha A., Gargouri Y., Bezzine S., Mejdoub H. Purification and biochemical characterization of phospholipase A2 from dromedary pancreas. Biochimica Biophysica Acta – General Subjects 2006; 1760: 1202-1209.
94. Ben Bacha A., Frikha F., Djemal I., Fendri A., Miled N., Gargouri Y., Mejdoub H. Biochemical and structural comparative study between bird and mammal pancreatic colipases. Journal of Lipid Research 2006; 47: 2701-2711.
95. Fendri A., Frikha F., Mosbah H., Miled N., Zouari N., Ben Bacha A., Sayari A., Mejdoub H., Gargouri Y. Biochemical characterization, cloning, and molecular modelling of chicken pancreatic lipase. Archives of Biochemistry and Biophysics 2006; 451: 149-159.
96. Ben BachaA., Gargouri Y., Ben Ali Y., Miled N., Reinbolt J., Mejdoub H. Purification and biochemical characterization of ostrich pancreatic lipase. Enzyme and Microbial Technology 2005; 37: 309-317.
Papers and Presentations at Conferences and Seminars:
1. Abir Ben Bacha, Norah Alorf, Afaf Elansary. Therapeutic effect of probiotic on clindamycin and propionic acid, a short chain fatty acid- induced neurotoxicity in juvenile hamsters. 30th annual forum of biological sciences and biotechnology organized by the Tunisian association of biological sciences. 25-28 March 2019, Sousse - Tunisia.
2. Abir Ben Bacha, A novel bactericidal homodimeric PLA2 group-I from Walterinnesia aegyptia venom. 7th International Congress of Biotechnology and Valorization of Bio-resources organized by The Tunisian Association of Biotechnology and Valorization of Bio-Resources (AT-BVBR). 20-23 March 2019, Tabarka – Tunisia.
3. Abir Ben Bacha, Norah Alorf, Afaf Elansary. Probiotic treatment reduces the autistic-like excitation/inhibition imbalance in juvenile hamsters induced by orally administered propionic acid and clindamycin. 7th International Congress of Biotechnology and Valorization of Bio-resources organized by The Tunisian Association of Biotechnology and Valorization of Bio-Resources (AT-BVBR). 20-23 March 2019, Tabarka – Tunisia.
4. Rawan Al-Nemari, Abir Ben Bacha, Abdulrahman Al-Senaidy, Abdelhabib Semlali. In vitro and vivo Studies for Assessing the Anti-Proliferative, Anti-Migration and Apoptotic Activity of A. squamosa L. Leaves Extract. ICCSCMG 2018: 20th International Conference on Cancer Stem Cells and Metastatic Growth. DUBAI, UAE JANUARY 22-23, 2018.
5. Abir Ben Bacha and Ikram Jemel. Inhibitory effects of various solvent extracts from R. frangula leaves on some inflammatory and metabolic enzymes (Oral communication). International Conference on Bioanalyses: Food and Health. Mahdia-Tunisia, December 4, 2017.
6. Abir Ben Bacha and Ikram Jemel. Purification and characterization of a newly serine protease inhibitor from Rhamnus frangula with potential for use as therapeutic drug (Poster communication). International Conference on Bioanalyses: Food and Health. Mahdia-Tunisia, December 4, 2017.
7. Asma M. Khemakhem, Afaf El-Ansary, Richard Eugene Fryeg, Laila Al-Ayadhi, Abir Ben Bacha. Relative levels of, potassium, sodium, lactate, pyruvate, and lactate dehydrogenase as biomarkers in plasma of Saudi autistic patients compared to control (Oral communication). 28th annual forum of biological sciences and biotechnology organized by the Tunisian association of biological sciences. 21-24 March 2017, Hammamet - Tunisia.
8. Asma M. Khemakhem, Afaf El-Ansary, Richard Eugene Fryeg, Laila Al-Ayadhi, Abir Ben Bacha. Screening of selected biomarkers related to mitochondrial dysfunction and associated with the severity of autism measured by Childhood Autism Rating Scale (CARS) (Oral communication).The third edition of the international conference of Engineering Sciences for Biology and Medicine (ESBM) organized by Tunisian Society of Academic Research (ATCU). 04-07 May, Sfax-Tunisia
9. Asma M. Khemakhem, Afaf El-Ansary, Richard Eugene Fryeg, Laila Al-Ayadhi, Abir Ben Bacha. Relative levels of selected biomarkers related to oxidative stress, apoptosis, and mitochondrial dysfunction as biomarkers in plasma of Saudi autistic patients compared to control (Poster). Vth International Congress of Biotechnology and Valorization of Bio-resources organized by The Tunisian Association of Biotechnology and Valorization of Bio-Resources (AT-BVBR). 25 March 2017, Tabarka – Tunisia.
10. El-Ansary A.K., Ben Bacha A., Kotb M. Etiology of autistic features: the persisting neurotoxic effects of propionic acid.Toxicology Summit & Expo, November San Antonio Airport, USA 26-28, 2012.
11. Jrad M, Kadri-Ben Chobba, Ben bacha A., Gharsallah N. Characterization of microorganisms isolated from the leaves of date palm healthy and sick producers of bioactive molecules. The Second African Congress on Biology and Health; Biogical and Pharmacological Activities of Natural Substances, Sétif-Algérie 10-12 Novembre 2012.
12. Jrad M, Kadri-Ben Chobba, Ben bacha A., Gharsallah N. Caractérisation des microorganismes endophytiques à partir des feuilles des palmiers sains et malades producteurs des biomolécules. Association Tunisienne des Sciences Biologiques 23éme forum, Hammamet-Tunisie 21 - 24 Mars 2012.
13. El-Ansary A.K., Ben Bacha A., Al-Ayadhi L.Y. Relationship between chronic lead toxicity and plasma neurotransmitters in autistic patients from Saudi Arabia. Ninth World Congress on Brain Injury, Edinburgh, Scotland March 21-25, 2012.
14. Ben Bacha A., Mejdoub H. Purification and biochemical characterization of pancreatic phospholipase A2 from the common stingray Dasyatis pastinaca. International Symposium of Biotechnology, Sousse-Tunisia, 19-22 December 2011.
15. Al-Ayadhi L.Y., Ben Bacha A., Kotb M., El-Ansary A.K. A novel study on amyloid beta peptide 40, 42 and 40/42 ratio in Saudi autistics. 16th International Conference of the APPAC. Greece May 17-20, 2011.
16. Zarai Z., Ben Bacha A., Gargouri Y., Mejdoub H. A novel marine hepatopancreatic phospholipase A2: Purification and characterization. 3rd Mediterranean Congress of Biotechnology, Hammamet-Tunisia, 15-18 December 2008.
17. Karray A., Ben Bacha A., Gargouri Y., Bezzine S. Purification, biochemical and structural characterization of turkey pancreatic phospholipase A2. 3rd Mediterranean Congress of Biotechnology, Hammamet-Tunisia, 15-18 December 2008.
18. Ben Bacha A., Gargouri Y., Mejdoub H., Miled N. Proteolytic cleavage of ostrich and turkey pancreatic lipases: production of an active N-terminal domain. 1st International Symposium on Biotechnology. Sfax-Tunisia, 4-8 May 2008.
19. Ben Bacha A., Frikha F., Miled N., Gargouri Y. Mejdoub H. Biochemical and structural comparative study between bird and mammal pancreatic colipases. 1st International Congress of Biochemistry of macromolecules and genetics. Gafsa-Tunisia, 12 - 16 April 2007.
20. Ben Bacha A., Gargouri Y., Mejdoub H. Purification and biochemical characterization of phospholipase A2 from ostrich pancreas. 18th Biology days of the Sciences Biology Tunisian Society, Hammamet- Tunisia 25-29 March 2007.
21. Miled N., Frikha F., Sayari A., Ben Bacha A., Gargouri Y. Structural importance of N-terminal regions of lipases. 1st Mediterranean Congress of Biotechnology, Hammammet-Tunisia, 25-29 March 2006.
22. Ben Bacha A., Djemel I, Gargouri Y., Mejdoub H. Purification and biochemical characterization of dromedary pancreatic colipase. 1st Mediterranean Congress of Biotechnology, Hammammet-Tunisia, 25-29 March 2006.
23. Ben Bacha A., Gargouri Y., Bezzine S., Mejdoub H. Purification et caractérisation biochimique de la phospholipase A2 pancréatique de dromadaire. 17ème journées de l’Association Tunisienne des Sciences Biologiques, et 1er Congrès Maghrébin de Biologie et de Biotechnologie. Hammammet-Tunisie, 20-23 Mars 2006.
24. Ben Bacha A., Gargouri Y., Mejdoub H. Purification et caractérisation biochimique de la lipase pancréatique d’autruche. 16ème journée de l’Association Tunisienne des Sciences Biologiques, Hammammet-Tunisie, 19-23 Mars 2005.
Workshops
1. “Influence and persuasion skills” (King Saud University - Saudi Arabia, Riyadh - October 2021).
2. “Creative teaching skills” (King Saud University - Saudi Arabia, Riyadh - October 2020).
3. “Classroom management” (King Saud University - Saudi Arabia, Riyadh - May 2013).
4. “Effective Teaching’’ (King Saud University - Saudi Arabia, Riyadh - May 2011).
5. ‘‘Active Learning in Large Classes’’ (King Saud University - Saudi Arabia, Riyadh - September 2010).
6. ‘‘Academic Guidance for Students’’ (King Saud University - Saudi Arabia, Riyadh - September 2010).
7. ‘‘Effective Teaching Skills’’ (King Saud University - Saudi Arabia, Riyadh - September 2010).
Personal Data
Name : Abir Ghanouchi-Ben Bacha
Sex and Marital Status : Female, Married with 3 children
Nationality : Tunisian
Occupation : Professor of Biochemistry
Languages : Arabic, French and English
Research Interest : Protein chemistry and Autism biomarkers
Contact Information
Personal telephone : 00966504784639
Office address : Department of Biochemistry, King Saud University,
PO Box 22452, Riyadh-11495, Saudi Arabia
Office phone : 00966-1-8055129
Emails : aalghanouchi@ksu.edu.sa
Diplomas:
- 2013: Academic Habilitation Degree, HDR Biological Engineering (ENIS - Sfax
University)
- 2007: PhD degree in biological engineering (ENIS - Sfax University)
(Title of Thesis: Ostrich digestive lipolytic enzymes: a comparative study with mammal enzymes)
- 2003: Master degree in biological engeneering (ENIS - Sfax University)
(Title: Purification and biochemical characterization of ostrich pancreatic lipase)
- 2000: Science degree in biological sciences in (FSS - Sfax University)
Work experience:
Teaching
April 2020 – Till date :Professor at King Saud University, Science College, Biochemistry department
2013 – 2020 : Associate Professor at King Saud University, Science College, Biochemistry department
2009 – 2013 : Assistant Professor at King Saud University, Science College, Biochemistry department
2007 – 2009 : Assistant Professor at faculty of sciences of Sfax
2003 – 2006 : Assistant at the faculty of sciences of Sfax
Teaching Activities:
Teaching many undergraduate and postgraduate courses
Supervision of 2 PhD and 11 Master Thesis
Research Grants:
- Principal investigator of a Research Project Nº RGP-VPP-070 "Biochemical and Structural Characterization of secreted phospholipases A2" financed by King Saud University, Kingdom of Saudi Arabia, (4/2011 - 4/2012).
- Co-investigator in a Research Project Nº RGP-VPP-005 "Treatment and preventive strategies of autism disease" financed by King Saud University, Kingdom of Saudi Arabia, (4/2011 - 4/2012).
- Researcher in a Research Project “Molecular detection of viruses and bacteria in treated waste water and in well water in the governorate of Al Riyadh, Saudi Arabia” Nº 12-ENV2528-02 supported by King Abdulaziz City for Science and Technology (KACST), (4/2014 - 4/2016).
- Co-investigator in a Research Project Nº RG-1435-083 financed by King Saud University, Kingdom of Saudi Arabia, (2/2017 - 2/2019).
- Co-investigator in a Research Project Nº RG-1441-471 financed by King Saud University, Kingdom of Saudi Arabia, (2/2020 - 2/2021).
- Co-investigator in a Research Project Nº RGP-070 financed by King Saud University, Kingdom of Saudi Arabia, (5/2020 - 5/2023).
- Principal investigator in a Research Project Nº IFKSUOR3-230 financed by King Saud University, Kingdom of Saudi Arabia, (5/2023 - 5/2024).
Publications
1. El-Sayed N.N.E; Al-Otaibi T.M.; Barakat A.; Almarhoon Z.M.; Hassan M. Z.; M.I. Al-Zaben; Krayem N.; Masand V.H.; Ben Bacha A. Synthesis and Biological Evaluation of Some New 3-Aryl-2-thioxo-2,3-dihydroquinazolin-4(1H)-ones and 3- Aryl-2-(benzylthio) quinazolin-4(3H)-ones as Antioxidants, COX-2, LDHA, α-Glucosidase and α-Amylase Inhibitors, as well as Anti-colon Carcinoma and Apoptosis. Accepted in pharmaceuticals.
2. Alonazi, M.; Krayem, N.; Alharbi, M.G.; Khayyat, A.I.A.; Alanazi, H.; Horchani, H.; Ben Bacha, A. Functional Characterization and Anti-Tumor Effect of a Novel Group II Secreted Phospholipase A2 from Snake Venom of Saudi Cerastes cerates gasperetti. Molecules 2023, 28, 6517. https://doi.org/10.3390/ molecules28186517
3. Alonazi M, Al-Diahan SK, Alzahrani ZRA, Ben Bacha A. Combined immobilized lipases for effective biodiesel production from spent coffee grounds. Saudi J Biol Sci. 2023 Sep;30(9):103772. doi: 10.1016/j.sjbs.2023.103772. Epub 2023 Aug 10. PMID: 37663395; PMCID: PMC10470282.
4. Kamalmaz N, Ben Bacha A, Alonazi M, Albasher G, Khayyat AIA, El-Ansary A. Unveiling sex-based differences in developing propionic acid-induced features in mice as a rodent model of ASD. PeerJ. 2023 Jun 13;11:e15488. doi: 10.7717/peerj.15488. PMID: 37334116; PMCID: PMC10274690.
5. Alonazi M, Ben Bacha A, Alharbi MG, Khayyat AIA, Al-Ayadhi L, El-Ansary A. Bee Pollen and Probiotics' Potential to Protect and Treat Intestinal Permeability in Propionic Acid-Induced Rodent Model of Autism. Metabolites. 2023 Apr 12;13(4):548. doi: 10.3390/metabo13040548. PMID: 37110206; PMCID: PMC10143803.
6. Nafaa M, Rizk SM, Aly TA-GA, Rashed MA-S, Abd El-Moneim D, Ben Bacha A, Alonazi M, Magdy M. Screening and Identification of the Rhizosphere Fungal Communities Associated with Land Reclamation in Egypt. Agriculture. 2023; 13(1):215. https://doi.org/10.3390/agriculture13010215
7. Alsubaiei SRM, Alfawaz HA, Almubarak AY, Alabdali NA, Ben Bacha A, El-Ansary A. Independent and Combined Effects of Probiotics and Prebiotics as Supplements or Food-Rich Diets on a Propionic-Acid-Induced Rodent Model of Autism Spectrum Disorder. Metabolites. 2022 Dec 29;13(1):50. doi: 10.3390/metabo13010050. PMID: 36676975; PMCID: PMC9863040.
8. Ben Bacha, A.; Alonazi, M.; Alharbi, M.G.; Horchani, H.; Ben Abdelmalek, I. Biodiesel Production by Single and Mixed Immobilized Lipases Using Waste Cooking Oil. Molecules 2022, 27, 8736. ht
9. Moutaouakil, M.; Tighadouini, S.; M. Almarhoon, Z.; I. Al-Zaben, M.; Ben Bacha, A.; H. Masand, V.; Jamaleddine, J.; Saddik, R. Quinoline Derivatives with Different Functional Groups: Evaluation of Their Catecholase Activity. Catalysts 2022, 12, 1468.
10. Ben Bacha, A., Alonazi, M., Alanazi, H., Alharbi, M. G., Jallouli, R., & Karray, A. (2022). Biochemical Study of Bacillus stearothermophilus Immobilized Lipase for Oily Wastewater Treatment. Processes, 10(11), 2220.
11. Alonazi M, Ben Bacha A, Al Suhaibani A, Almnaizel AT, Aloudah HS, El-Ansary A. Psychobiotics improve propionic acid-induced neuroinflammation in juvenile rats, rodent model of autism. Transl Neurosci. 2022 Sep 8;13(1):292-300.
12. Saddik R, Hammoudan I, Tighadouini S, Roby O, Radi S, Al-Zaben MI, Ben Bacha A, Masand VH, Almarhoon ZM. Mesoporous Silica Modified with 2-Phenylimidazo[1,2-a] pyridine-3-carbaldehyde as an Effective Adsorbent for Cu(II) from Aqueous Solutions: A Combined Experimental and Theoretical Study. Molecules. 2022 Aug 13;27(16):5168.
13. El-Sayed NNE, Zaki MEA, Al-Hussain SA, Ben Bacha A, Berredjem M, Masand VH, Almarhoon ZM, Omar HS. Synthesis and Evaluation of Some New 4H-Pyran Derivatives as Antioxidant, Antibacterial and Anti-HCT-116 Cells of CRC, with Molecular Docking, Antiproliferative, Apoptotic and ADME Investigations. Pharmaceuticals (Basel). 2022 Jul 19;15(7):891.
14. Al-Nemari, R., Ben Bacha, A., Al-Senaidy, A., Almutairi, M.H., Arafah, M., Al-Saran, H., Abutaha, N., & Semlali, A. Cytotoxic effects of Annona squamosa leaves against breast cancer cells via apoptotic signaling proteins. Journal of King Saud University - Science. 2022 Jun; 34 (4): 102013
15. Karray A, Alonazi M, Jallouli R, Alanazi H, Ben Bacha A. A Proteinaceous Alpha-Amylase Inhibitor from Moringa Oleifera Leaf Extract: Purification, Characterization, and Insecticide Effects against C. maculates Insect Larvae. Molecules. 2022 Jun 30;27(13):4222.
16. El-Sayed NNE, Almaneai NM, Ben Bacha A, El-Ashrey MK, Al-Zaben MI, Almarhoon ZM. Biological Evaluation, Molecular Docking Analyses, and ADME Profiling of Certain New Quinazolinones as Anti-colorectal Agents. ACS Omega. 2022 May 23;7(22):18443-18458.
17. Alonazi M, Karray A, Jallouli R, Ben Bacha A. Biochemical, Kinetic and Biological Properties of Group V Phospholipase A2 from Dromedary. Molecules. 2022 May 26;27(11):3437.
18. Malhi DS, Sohal HS, Singh K, Almarhoon ZM, Ben Bacha A, Al-Zaben MI. Highly Efficient Electrocarboxylation Method to Synthesize Novel Acid Derivatives of 1,4-Dihydropyridines and to Study Their Antimicrobial Activity. ACS Omega. 2022 Apr 28;7(18):16055-16062.
19. Almarhoon, Z, Al-Zaben, M, Ben Bacha A, Haukka, M, El-Faham, A & Soliman, S. (2021). Synthesis, X-ray Structure, Conformational Analysis, and DFT Studies of a Giant s-Triazine bis-Schiff Base. Crystals. 11. 1418. 10.3390/cryst11111418.
20. Kamal S, Derbala HA, Alterary SS, Ben Bacha A, Alonazi M, El-Ashrey MK, Eid El-Sayed NN. Synthesis, Biological, and Molecular Docking Studies on 4,5,6,7-Tetrahydrobenzo[b]thiophene Derivatives and Their Nanoparticles Targeting Colorectal Cancer. ACS Omega. 2021 Oct 25;6(43):28992-29008.
21. Ben Bacha A, Al-Orf N, Alonazi M, Bhat RS, El-Ansary A. The anti-inflammatory and antiapoptotic effects of probiotic on induced neurotoxicity in juvenile hamsters. Food Sci Nutr. 2021 Jul 13;9(9):4874-4882.
22. Al Suhaibani A, Ben Bacha A, Alonazi M, Shafi Bhat R.S, El-Ansary Afaf, Testing the combined effects of probiotics and prebiotics against neurotoxic effects of propionic acid orally administered to rat pups. Food Sci Nutr. 2021;00:1–12.
23. El-Sayed NNE, Al-Otaibi TM, Alonazi M, Masand VH, Barakat A, Almarhoon ZM, Ben Bacha A. Synthesis and Characterization of Some New Quinoxalin-2(1H)one and 2-Methyl-3H-quinazolin-4-one Derivatives Targeting the Onset and Progression of CRC with SRA, Molecular Docking, and ADMET Analyses. Molecules. 2021 May 23;26(11):3121.
24. Alonazi, M.; Karray, A.; Badjah-Hadj-Ahmed, A.Y.; Ben Bacha, A. Al-pha Amylase from Bacillus pacificusAssociated with Brown Algae Turbina-ria ornata: Cultural Conditions, Pu-rification, and Biochemical Character-ization. Processes 2021, 9, 16.
25. Karray A, Alonazi M, Horchani H, Ben Bacha A. A Novel Thermostable and Alkaline Protease Produced from Bacillus stearothermophilus Isolated from Olive Oil Mill Sols Suitable to Industrial Biotechnology. Molecules. 2021 Feb 20;26(4):1139.
26. Alonazi MA, Jemel I, Moubayed N, Alwhibi M, El-Sayed NNE, Ben Bacha A. Evaluation of the in vitro anti-inflammatory and cytotoxic potential of ethanolic and aqueous extracts of Origanum syriacum and Salvia lanigera leaves. Environ Sci Pollut Res Int. 2021 Apr; 28(16):19890-19900.
27. Alonazi M, Horchani H, Alwhibi M, Ben Bacha A. Cytotoxic, Antioxidant, and Metabolic Enzyme Inhibitory Activities of Euphorbia cyparissias Extracts. Oxid Med Cell Longev. 2020 Oct 29;2020:9835167.
28. Abid, I.; Jemel, I.; Alonazi, M.; Ben Bacha, A. A New Group II Phospholipase A2 from Walterinnesia aegyptia Venom with Antimicrobial, Antifungal, and Cytotoxic Potential. Processes 2020, 8, 1560.
29. El-Ansary A, Hassan WM, Daghestani M, Al-Ayadhi L, Ben Bacha A. Preliminary evaluation of a novel nine-biomarker profile for the prediction of autism spectrum disorder. PLoS One. 2020 Jan 16;15(1):e0227626.
30. Ben Bacha A, Norah AO, Al-Osaimi M, Harrath AH, Mansour L, El-Ansary A. The therapeutic and protective effects of bee pollen against prenatal methylmercury induced neurotoxicity in rat pups. Metab Brain Dis. 2020 Jan;35(1):215-224.
31. Al-Nemari R, Al-Senaidy A, Semlali A, Ismael M, Badjah-Hadj-Ahmed AY, Ben Bacha A. GC-MS profiling and assessment of antioxidant, antibacterial, and anticancer properties of extracts of Annona squamosa L. leaves. BMC Complement Med Ther. 2020 Oct 6;20(1):296.
32. Karray A, Alonazi M, Smaoui S, Michaud P, Soliman D, Ben Bacha A. Purification and Biochemical Characterization of a New Protease Inhibitor from Conyza dioscoridis with Antimicrobial, Antifungal and Cytotoxic Effects. Molecules. 2020 Nov 20;25(22):5452.
33. Abid, I.; Jemel, I.; Alonazi, M.; Ben Bacha, A. A New Group II Phospholipase A2 from Walterinnesia aegyptia Venom with Antimicrobial, Antifungal, and Cytotoxic Potential. Processes 2020, 8, 1560.
34. El-Ansary A, Hassan WM, Daghestani M, Al-Ayadhi L, Ben Bacha A. Preliminary evaluation of a novel nine-biomarker profile for the prediction of autism spectrum disorder. PLoS One. 2020 Jan 16;15(1):e0227626. doi: 10.1371/journal.pone.0227626. PMID: 31945130; PMCID: PMC6964874.
35. Ben Bacha A, Norah AO, Al-Osaimi M, Harrath AH, Mansour L, El-Ansary A. The therapeutic and protective effects of bee pollen against prenatal methylmercury induced neurotoxicity in rat pups. Metab Brain Dis. 2020 Jan;35(1):215-224. doi: 10.1007/s11011-019-00496-z. Epub 2019 Oct 17. PMID: 31625070.
36. Al-Nemari R, Al-Senaidy A, Semlali A, Ismael M, Badjah-Hadj-Ahmed AY, Ben Bacha A. GC-MS profiling and assessment of antioxidant, antibacterial, and anticancer properties of extracts of Annona squamosa L. leaves. BMC Complement Med Ther. 2020 Oct 6;20(1):296. doi: 10.1186/s12906-020-03029-9. PMID: 33023568; PMCID: PMC7541211.
37. Karray A, Alonazi M, Smaoui S, Michaud P, Soliman D, Ben Bacha A. Purification and Biochemical Characterization of a New Protease Inhibitor from Conyza dioscoridis with Antimicrobial, Antifungal and Cytotoxic Effects. Molecules. 2020 Nov 20;25(22):5452. doi: 10.3390/molecules25225452. PMID: 33233753; PMCID: PMC7699837.
38. Bhat RS, El Gezeery A, Ben Bacha A, Alonazi MA, Alsuhaibani LS, and El-Ansary A. Prenatal exposure to the fluoride containing psychiatric drug fluoxetine and anti-oxidative alterations in the neonatal rat brain. BIOCELL 2019, 43(2): 65-71.
39. Al-Nuwaysir H, Moubayed N, Al-Othman M, Ben Bacha A, and Abid I. Molecular detection of Escherichia coli in Wadi Hanifa, Saudi Arabia. Biomedical Research (2019) Volume 30, Issue 2.
40. Nahed N. E. El-Sayed, Norah M. Almaneai, Saied M. Soliman, Abir Ben Bacha and Hazem A. Ghabbour. Synthesis, Structural Investigation, Antiphospholipases, Antiproteases and antimicrobial activities of 2-(4-hydroxy-3-methoxy-benzylidene)-6-methoxy-3,4-dihydro-2H-naphthalen-1-one and 4‑(4‑hydroxy-3-methoxy-phenyl)-8-methoxy-3,4,5,6-tetrahydro-1H-benzo[h] quinazoline-2-thione. Journal of the Chemical Society of Pakistan. 2019 Dec; 41 (06).
41. El-Sayed NNE, Almaneai NM, Ben Bacha A, Al-Obeed O, Ahmad R, Abdulla M, Alafeefy AM. Synthesis and evaluation of anticancer, antiphospholipases, antiproteases, and antimetabolic syndrome activities of some 3H-quinazolin-4-one derivatives. J Enzyme Inhib Med Chem. 2019 Dec; 34(1):672-683. doi: 10.1080/14756366.2019.1574780.
42. A. El-Ansary, N. Zayed, M.H. Daghestani1, A. Ben Bacha. Metabolic and Immune Aspects of Sex Differences in Autism. Recent Advances in Autism Chapter 2. 2019
43. Ben Bacha A, Jemel I, Shafi Bhat R, and Alonazi MA. Inhibitory effects of various solvent extracts from R. frangula leaves on some inflammatory and metabolic enzymes. Cell Mol Biol (Noisy-le-grand). 2018 Oct 30; 64 (13):55-62.
44. Al-Orf N, El-Ansary A, Bjørklund G, Moubayed N, Bhat RS, Ben Bacha A. Therapeutic effects of probiotics on neurotoxicity induced by clindamycin and propionic acid in juvenile hamsters. Metab Brain Dis. 2018 Dec; 33 (6):1811-1820.
45. Al-Osaimi M, El-Ansary A, Al-Daihan S, Bhat RS, Ben Bacha A. Therapeutic and Protective Potency of Bee Pollen Against Neurotoxic Effects Induced by Prenatal Exposure of Rats to Methyl Mercury. J Mol Neurosci. 2018 Jul;65(3):327-335. doi: 10.1007/s12031-018-1107-1.
46. El-Ansary A, Bjørklund G, Khemakhem AM, Al-Ayadhi L, Chirumbolo S, Ben Bacha A. Metabolism-Associated Markers and Childhood Autism Rating Scales (CARS) as a Measure of Autism Severity. J Mol Neurosci. 2018 Jul;65(3):265-276. doi: 10.1007/s12031-018-1091-5. Epub 2018 Jun 22.
47. Ben Bacha A, Alonazi MA, Elshikh MS, Karray A. A novel bactericidal homodimeric PLA2 group-I from Walterinnesia aegyptia venom. Int J Biol Macromol. 2018; 117:1140-1146.
48. Ben Bacha A and Abid I. Hydrolysis of oils in the Wadi Hanifah River in Saudi Arabia by free and immobilized Staphylococcus aureus ALA1 lipase. Environmental Progress & Sustainable Energy. 2018; DOI 10.1002/ep.13000
49. El-Ansary A, Ben Bacha A, Bjørklund G, Al-Orf N, Bhat RS, Moubayed N, Abed K. Probiotic treatment reduces the autistic- like excitation/inhibition imbalance in juvenilehamsters induced by orally administered propionic acid and clindamycin. Metab Brain Dis. 2018 Aug; 33(4):1155-1164.
50. Al-Daihan S, Ben Bacha A, El-Ansary A, Bhat RS. PRENATAL BEE POLLEN TREATMENT IMPROVES THE NEUROTOXICITY IN NEW BORN RATS DURING CHRONIC FLUORIDES EXPOSURE IN RELATION TO PROPIONIC ACID -INDUCED RODENT MODELS OF AUTISM. Accepted in Fluoride, 2018
51. Al-Daihan S, Ben Bacha A, Al-Dbass AM, Alonazi MA. and Shafi Bhat R. High-fat diet stimulates the gut pathogenic microbiota and maintains hepatic injury in antibiotic-treated rats. Cell Mol Biol (Noisy-le-grand). 2018 Jan 31;64(1):103-106.
52. Al-Bagmi MS, Khan MS, Ismail MH, Al-Senaidy AM, Ben Bacha A, Husain FM, Alamery SF. An efficient methodology for the purification of date palm peroxidase: Stability comparison with Horseradish Peroxidase (HRP). Saudi Journal of Biological Sciences. Available online 12 April 2018. Volume 26, Issue 2, February 2019, Pages 301-307
53. Alasmary FAS, Alnahdi FS, Ben Bacha A, El-Araby AM, Moubayed N, Alafeefy AM, El-Araby ME. New quinoxalinone inhibitors targeting secreted phospholipase A2 and α-glucosidase. J Enzyme Inhib Med Chem. 2017 Dec;32(1):1143-1151.
54. Ben Abdelmalek I., Alzaiydi A. and Ben Bacha A. THE BIOREFINING OF SAUDI ARABIAN WASTE DATE: AN ENVIRONMENTAL PROMISING ALTERNATIVE TO PETROCHEMISTRY. Int. J. Adv. Res. 5(4), 1250-1261
55. Khemakhem A., Frye RE., El-Ansary A., Al-Ayadhi A. and Ben Bacha A. Novel biomarkers of metabolic dysfunction is autism spectrum disorder: potential for biological diagnostic markers. Metab Brain Dis. 2017 Dec;32(6):1983-1997. doi: 10.1007/s11011-017-0085-2.
56. Moubayed NM. and Ben Bacha A. PLA2 inhibitory, antioxidant and antibacterial properties of various solvent extracts from R. frangula leaves Biomedical Research 2017; 28 (4): 1844-1850.
57. Ben Bacha A. Jemel I., Moubayed NM. and Ben Abdelmalek I. Purification and characterization of a newly serine protease inhibitor from Rhamnus frangula with potential for use as therapeutic drug. 3 Biotech (2017) 7:148.
58. El-Sayed NN, Alafeefy AM, Bakht MA, Masand VH, Aldalbahi A, Chen N, Fan C, Ben Bacha A. Synthesis, Antiphospholipase A2, Antiprotease, Antibacterial Evaluation and Molecular Docking Analysis of Certain Novel Hydrazones. Molecules. 2016 Dec 2; 21(12).
59. Ben Bacha A, Al-Assaf A., Moubayed NM. and Abid I. A novel high thermo-alkaline Staphylococcus aureus lipase: an ideal choice for application in detergent formulations. Saudi Journal of Biological science 2018; 25: 409–417
60. Ben Bacha A., Moubayed NM. and Al-Assaf A. An organic solvent-stable lipase from a newly isolated staphylococcus aureus ALA1 strain with potential for use as an industrial biocatalyst. Biotechnol Appl Biochem. 2016; 63(3):378-90.
61. Ben Bacha A., Moubayed NM. and Abid I. Thermostable alkaline and detergent-tolerant lipase from a newly isolated thermophilic Bacillus stearothermophilus. Indian J Biochem Biophys. 2015; 52(2): 179-88.
62. El-Meligy RM., Awaad AS., Soliman GA., Ben Bacha A., Alafeefy AM., and Kenawy SA Prophylactic and Curative Anti-ulcerative colitis activity and the possible mechanisms of action of some desert plants. J Enzyme Inhib Med Chem. 2015; 30(2):250-8.
63. Alafeefy AM., Awaad AS., Abdel-Aziz HA., El-Meligy RM., Zain ME., Al-Outhman MR. and Ben Bacha A. Synthesis and biological evaluation of certain 3-substituted benzylideneamino-2-(4-nitrophenyl)quinazolin-4(3H)-one derivatives. J Enzyme Inhib Med Chem. 2015; 30(2):270-6.
64. Ben Bacha A Anti-Bactericidal Properties of Stingray Dasyatis pastinaca Groups V, IIA, and IB Phospholipases A2: A Comparative Study. Appl Biochem Biotechnol. 2014;174(4):1520-34.
65. Ben Bacha A., Abid I., Horchani H., Mejdoub H. Enzymatic properties of stingray Dasyatis pastinaca group V, IIA and IB phospholipases A2: A comparative study. International Journal of Biological Macromolecules 2013; 62: 537-542.
66. El-Ansary A, Al-Daihan S, Bacha AB, Kotb M. Toxicity of novel nanosized formulations used in medicine. Methods Mol Biol. 2013;1028:47-74
67. Ben Bacha A., Al-Daihan S., Mejdoub H. Purification and characterization of a new organic-solvent-tolerant SPLA2-IIA from common stingray intestine. Indian Journal of Biochemistry & Biophysics 2013; 50: 186-195.
68. Ben Bacha A., Al-Daihan S., Mejdoub H. Purification, characterization and antibacterial activities of of phospholipase A2 from the dromedary intestine. International Journal of Biological Macromolecules 2013; 57: 156– 164.
69. Ben Bacha A., Abid I. Secretory Phospholipase A(2) in Dromedary Tears: a Host Defense Against Staphylococci and Other Gram-Positive Bacteria. Applied Biochemistry and Biotechnology 2013; 169(6):1858-69.
70. El-Ansary A.K., Al-Daihan S., Ben Bacha A., Shaker G.H., Al-Ayadhi L. Comparative study on the protective effect of Carnosine and Carnitine against pro-inflammatory/ pro-oxidant effects of Clindamycin and Propionic acid administrations to hamsters. African Journal of Microbiology Research 2013; 7(2):103-114.
71. Ben Bacha A., Abid I., Horchani H. Antibacterial properties of intestinal phospholipase A2 from the common stingray Dasyatis pastinaca. Applied Biochemistry and Biotechnology 2012; 168:1277-1287.
72. El-Ansary A.K., Ben Bacha A., Kotb M. Etiology of autistic features: the persisting neurotoxic effects of propionic acid. Journal of Neuroinflammation 2012; 9: 74.
73. Hammami I., Jaouadi B., Ben Bacha A., Rebai A., Bejar S., Nesme X., Rhouma A. Bacillus subtilisbacteriocin Bac 14B with a broad inhibitory spectrum: Purification, amino acid sequence analysis, and physicochemical characterization. Biotechnology and Bioprocess Engineering 2012; 17 (1): 41-49.
74. Al-Ayadhi L.Y., Ben Bacha A., Kotb M., El-Ansary A.K. A novel study on amyloid beta peptide 40, 42 and 40/42 ratio in Saudi autistics. Behavioral and Brain Function 2012, 8(1): 4.
75. Ben Bacha A., Mejdoub H. Purification and biochemical characterization of an organic-solvent-tolerant thioredoxin from dromedary pancreas. Protein Journal 2012; 31(1): 1-7.
76. El-Ansary A.K., Ben Bacha A., Al-Ayadhi LY. Proinflammatory and proapoptotic markers in relation to mono and di-cations in plasma of autistic patients from Saudi Arabia. J Neuroinflammation. 2011 Oct 15;8:142.
77. Ben Bacha A., Mejdoub H. Proteolytic cleavage of stingray phospholipase A2: Isolation and biochemical characterization of an active N-terminal form. Lipids in Health and Disease 2011; 10: 124.
78. El-Ansary A.K., Ben Bacha A., Al- Ayadhi L.Y. Relationship between chronic lead toxicity and plasma neurotransmitters in autistic patients from Saudi Arabia. Clinical Biochemistry 2011; 44(13): 1116-20.
79. El-Ansary A.K., Ben Bacha A., Al- Ayadhi L.Y. Impaired plasma phospholipids and relative amounts of essential polyunsaturated fatty acids in autistic patients from Saudi Arabia. Lipids Health Disease 2011; 10 (1): 63.
80. El-Ansary A.K., Ben Bacha A., Al- Ayadhi L.Y. Plasma fatty acids as diagnostic markers in Saudi autistics. Lipids in Health and Disease 2011; 10 (1): 62
81. Ben Bacha A., Karray A., Daoud L., Bouchaala E., Bou Ali M., Gargouri Y., Ben Ali Y. Biochemical properties of pancreatic colipase from the common stingray Dasyatis pastinaca. Lipids in Health and Disease 2011; 10: 69. (IF: 2.170)
82. Ben Bacha A., Karray A., Bouchaala E., Gargouri Y., Ben Ali Y Purification and biochemical characterization of pancreatic phospholipase A2 from the common stingray Dasyatis pastinaca. Lipids in Health and Disease 2011; 10(1): 32.
83. Damak N., Hadj-Taieb N., Bonnin E., Ben Bacha A., Gargouri A. Purification and biochemical characterization of a novel thermoactive fungal pectate lyase from Penicillium occitanis. Process Biochemistry 2011; 46 (4): 888-893.
84. Cherif S., Ben Bacha A., Ben Ali Y., Horchani H., Rekik W., Gargouri.Y. Crab digestive phospholipase: a new invertebrate member. Bioresource Technology 2010; 101 (1): 366-71.
85. Zarai Z., Ben Bacha A., Horchani H., Bezzine S., Gargouri Y., Mejdoub H. A novel marine hepatopancreatic phospholipase A2 with digestive and toxic activities. Archives of Biochemistry and Biophysics 2010; 494(2): 121-129.
86. Miled N., Fikha F., Ben Bacha A., Mejdoub H. Gargouri Y. Structural homologies, importance for catalysis and lipid binding of the N-terminal Peptide of a fungal and a pancreatic lipase. Protein Peptide Letters 2010; 17(2): 254-259.
87. Blibech M., Ghorbel R.E., Fakhfakh I., Ntarima P., Piens K., Ben Bacha A., Ellouz Chaabouni S. Purification and characterization of a low molecular weight of beta-mannanase from Penicillium occitanis Pol6. Applied Biochemistry and Biotechnology 2010; 160(4):1227-40.
88. Zouari N., Elgharb F., Fakhfakh N., Ben Bacha A., Gargouri Y., Miled N. Effect of dietary vitamin E supplementation on lipid and colour stability of chicken thigh meat. African Journal of Biotechnology 2010; 9(15): 2276-2283.
89. Karray A., Frikha F., Ben Bacha A., Ben Ali Y., Gargouri Y., Bezzine S. Purification, biochemical and structural characterization of turkey pancreatic phospholipase A2. FEBS Journal 2009; 276: 4545-4554.
90. Ben Bacha A., Gargouri Y., Bezzine S., Mosbah H., Mejdoub H. A bird pancreatic phospholipase A2: Purification and biochemical characterization. Journal of Chromatography B 2007; 857(1):108-114.
91. Ben Bacha A., Fendri A., Gargouri Y., Mejdoub H., Miled N. Proteolytic cleavage of ostrich and turkey pancreatic lipases: Production of a fully active N-terminal domain. Pancreas 2007; 35: 55-61.
92. Fendri A., Frikha F., Miled N., Ben Bacha A., Gargouri Y. Modulating the activity of avian pancreatic lipases by the alkyl chain reacting with an accessible Sulfhydryl group. Biochemical and Biophysical Research Communications 360 (2007) 765-771.
93. Ben Bacha A., Gargouri Y., Bezzine S., Mejdoub H. Purification and biochemical characterization of phospholipase A2 from dromedary pancreas. Biochimica Biophysica Acta – General Subjects 2006; 1760: 1202-1209.
94. Ben Bacha A., Frikha F., Djemal I., Fendri A., Miled N., Gargouri Y., Mejdoub H. Biochemical and structural comparative study between bird and mammal pancreatic colipases. Journal of Lipid Research 2006; 47: 2701-2711.
95. Fendri A., Frikha F., Mosbah H., Miled N., Zouari N., Ben Bacha A., Sayari A., Mejdoub H., Gargouri Y. Biochemical characterization, cloning, and molecular modelling of chicken pancreatic lipase. Archives of Biochemistry and Biophysics 2006; 451: 149-159.
96. Ben BachaA., Gargouri Y., Ben Ali Y., Miled N., Reinbolt J., Mejdoub H. Purification and biochemical characterization of ostrich pancreatic lipase. Enzyme and Microbial Technology 2005; 37: 309-317.
Papers and Presentations at Conferences and Seminars:
1. Abir Ben Bacha, Norah Alorf, Afaf Elansary. Therapeutic effect of probiotic on clindamycin and propionic acid, a short chain fatty acid- induced neurotoxicity in juvenile hamsters. 30th annual forum of biological sciences and biotechnology organized by the Tunisian association of biological sciences. 25-28 March 2019, Sousse - Tunisia.
2. Abir Ben Bacha, A novel bactericidal homodimeric PLA2 group-I from Walterinnesia aegyptia venom. 7th International Congress of Biotechnology and Valorization of Bio-resources organized by The Tunisian Association of Biotechnology and Valorization of Bio-Resources (AT-BVBR). 20-23 March 2019, Tabarka – Tunisia.
3. Abir Ben Bacha, Norah Alorf, Afaf Elansary. Probiotic treatment reduces the autistic-like excitation/inhibition imbalance in juvenile hamsters induced by orally administered propionic acid and clindamycin. 7th International Congress of Biotechnology and Valorization of Bio-resources organized by The Tunisian Association of Biotechnology and Valorization of Bio-Resources (AT-BVBR). 20-23 March 2019, Tabarka – Tunisia.
4. Rawan Al-Nemari, Abir Ben Bacha, Abdulrahman Al-Senaidy, Abdelhabib Semlali. In vitro and vivo Studies for Assessing the Anti-Proliferative, Anti-Migration and Apoptotic Activity of A. squamosa L. Leaves Extract. ICCSCMG 2018: 20th International Conference on Cancer Stem Cells and Metastatic Growth. DUBAI, UAE JANUARY 22-23, 2018.
5. Abir Ben Bacha and Ikram Jemel. Inhibitory effects of various solvent extracts from R. frangula leaves on some inflammatory and metabolic enzymes (Oral communication). International Conference on Bioanalyses: Food and Health. Mahdia-Tunisia, December 4, 2017.
6. Abir Ben Bacha and Ikram Jemel. Purification and characterization of a newly serine protease inhibitor from Rhamnus frangula with potential for use as therapeutic drug (Poster communication). International Conference on Bioanalyses: Food and Health. Mahdia-Tunisia, December 4, 2017.
7. Asma M. Khemakhem, Afaf El-Ansary, Richard Eugene Fryeg, Laila Al-Ayadhi, Abir Ben Bacha. Relative levels of, potassium, sodium, lactate, pyruvate, and lactate dehydrogenase as biomarkers in plasma of Saudi autistic patients compared to control (Oral communication). 28th annual forum of biological sciences and biotechnology organized by the Tunisian association of biological sciences. 21-24 March 2017, Hammamet - Tunisia.
8. Asma M. Khemakhem, Afaf El-Ansary, Richard Eugene Fryeg, Laila Al-Ayadhi, Abir Ben Bacha. Screening of selected biomarkers related to mitochondrial dysfunction and associated with the severity of autism measured by Childhood Autism Rating Scale (CARS) (Oral communication).The third edition of the international conference of Engineering Sciences for Biology and Medicine (ESBM) organized by Tunisian Society of Academic Research (ATCU). 04-07 May, Sfax-Tunisia
9. Asma M. Khemakhem, Afaf El-Ansary, Richard Eugene Fryeg, Laila Al-Ayadhi, Abir Ben Bacha. Relative levels of selected biomarkers related to oxidative stress, apoptosis, and mitochondrial dysfunction as biomarkers in plasma of Saudi autistic patients compared to control (Poster). Vth International Congress of Biotechnology and Valorization of Bio-resources organized by The Tunisian Association of Biotechnology and Valorization of Bio-Resources (AT-BVBR). 25 March 2017, Tabarka – Tunisia.
10. El-Ansary A.K., Ben Bacha A., Kotb M. Etiology of autistic features: the persisting neurotoxic effects of propionic acid.Toxicology Summit & Expo, November San Antonio Airport, USA 26-28, 2012.
11. Jrad M, Kadri-Ben Chobba, Ben bacha A., Gharsallah N. Characterization of microorganisms isolated from the leaves of date palm healthy and sick producers of bioactive molecules. The Second African Congress on Biology and Health; Biogical and Pharmacological Activities of Natural Substances, Sétif-Algérie 10-12 Novembre 2012.
12. Jrad M, Kadri-Ben Chobba, Ben bacha A., Gharsallah N. Caractérisation des microorganismes endophytiques à partir des feuilles des palmiers sains et malades producteurs des biomolécules. Association Tunisienne des Sciences Biologiques 23éme forum, Hammamet-Tunisie 21 - 24 Mars 2012.
13. El-Ansary A.K., Ben Bacha A., Al-Ayadhi L.Y. Relationship between chronic lead toxicity and plasma neurotransmitters in autistic patients from Saudi Arabia. Ninth World Congress on Brain Injury, Edinburgh, Scotland March 21-25, 2012.
14. Ben Bacha A., Mejdoub H. Purification and biochemical characterization of pancreatic phospholipase A2 from the common stingray Dasyatis pastinaca. International Symposium of Biotechnology, Sousse-Tunisia, 19-22 December 2011.
15. Al-Ayadhi L.Y., Ben Bacha A., Kotb M., El-Ansary A.K. A novel study on amyloid beta peptide 40, 42 and 40/42 ratio in Saudi autistics. 16th International Conference of the APPAC. Greece May 17-20, 2011.
16. Zarai Z., Ben Bacha A., Gargouri Y., Mejdoub H. A novel marine hepatopancreatic phospholipase A2: Purification and characterization. 3rd Mediterranean Congress of Biotechnology, Hammamet-Tunisia, 15-18 December 2008.
17. Karray A., Ben Bacha A., Gargouri Y., Bezzine S. Purification, biochemical and structural characterization of turkey pancreatic phospholipase A2. 3rd Mediterranean Congress of Biotechnology, Hammamet-Tunisia, 15-18 December 2008.
18. Ben Bacha A., Gargouri Y., Mejdoub H., Miled N. Proteolytic cleavage of ostrich and turkey pancreatic lipases: production of an active N-terminal domain. 1st International Symposium on Biotechnology. Sfax-Tunisia, 4-8 May 2008.
19. Ben Bacha A., Frikha F., Miled N., Gargouri Y. Mejdoub H. Biochemical and structural comparative study between bird and mammal pancreatic colipases. 1st International Congress of Biochemistry of macromolecules and genetics. Gafsa-Tunisia, 12 - 16 April 2007.
20. Ben Bacha A., Gargouri Y., Mejdoub H. Purification and biochemical characterization of phospholipase A2 from ostrich pancreas. 18th Biology days of the Sciences Biology Tunisian Society, Hammamet- Tunisia 25-29 March 2007.
21. Miled N., Frikha F., Sayari A., Ben Bacha A., Gargouri Y. Structural importance of N-terminal regions of lipases. 1st Mediterranean Congress of Biotechnology, Hammammet-Tunisia, 25-29 March 2006.
22. Ben Bacha A., Djemel I, Gargouri Y., Mejdoub H. Purification and biochemical characterization of dromedary pancreatic colipase. 1st Mediterranean Congress of Biotechnology, Hammammet-Tunisia, 25-29 March 2006.
23. Ben Bacha A., Gargouri Y., Bezzine S., Mejdoub H. Purification et caractérisation biochimique de la phospholipase A2 pancréatique de dromadaire. 17ème journées de l’Association Tunisienne des Sciences Biologiques, et 1er Congrès Maghrébin de Biologie et de Biotechnologie. Hammammet-Tunisie, 20-23 Mars 2006.
24. Ben Bacha A., Gargouri Y., Mejdoub H. Purification et caractérisation biochimique de la lipase pancréatique d’autruche. 16ème journée de l’Association Tunisienne des Sciences Biologiques, Hammammet-Tunisie, 19-23 Mars 2005.
Workshops
1. “Influence and persuasion skills” (King Saud University - Saudi Arabia, Riyadh - October 2021).
2. “Creative teaching skills” (King Saud University - Saudi Arabia, Riyadh - October 2020).
3. “Classroom management” (King Saud University - Saudi Arabia, Riyadh - May 2013).
4. “Effective Teaching’’ (King Saud University - Saudi Arabia, Riyadh - May 2011).
5. ‘‘Active Learning in Large Classes’’ (King Saud University - Saudi Arabia, Riyadh - September 2010).
6. ‘‘Academic Guidance for Students’’ (King Saud University - Saudi Arabia, Riyadh - September 2010).
7. ‘‘Effective Teaching Skills’’ (King Saud University - Saudi Arabia, Riyadh - September 2010).