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Ajamaluddin Malik

Associate Professor

Associate Professor

كلية العلوم
Building no 5, room no 2A56
المنشورات
مقال فى مجلة
2018

Co-circulation of Chikungunya and Dengue viruses in Dengue endemic region of New Delhi, India during 2016

S, Hisamuddin M, Tazeen A, Abdullah M, Islamuddin M, Parveen N, Islam A, Faizan MI, Hamza A, Naqvi IH, Verma HN, Ajamaluddin Malik, Ahmed A, Parveen . 2018

Co-circulation of Chikungunya and Dengue viral infections (CHIKV and DENV) have been reported mainly due to transmission by common Aedes vector. The purpose of the study was to identify and characterise the circulating strains of CHIKV and DENV in DENV endemic region of New Delhi during 2016. CHIKV and DENV were identified in the blood samples (n = 130) collected from suspected patients by RT-PCR. CHIKV was identified in 26 of 65 samples (40%). Similarly, DENV was detected in 48 of 120 samples (40%). Co-infection with both the viruses was identified in five (9%) of the samples. Interestingly, concurrent infection with DENV, CHIKV and Plasmodium vivax was detected in two samples. CHIKV strains (n = 11) belonged to the ECSA genotype whereas DENV-3 sequences (n = eight) clustered in Genotype III by phylogenetic analysis. Selection pressure of E1 protein of CHIKV and CprM protein of DENV-3 revealed purifying selection with four and two positive sites, respectively. Four amino acids of the CHIKV were positively selected and had high entropy suggesting probable variations. Co-circulation of both viruses in DENV endemic regions warrants effective monitoring of these emerging pathogens via comprehensive surveillance for implementation of effective control measures.

رقم المجلد
146
رقم الانشاء
13
مجلة/صحيفة
Epidemiol Infect
الصفحات
1-12
مزيد من المنشورات
publications

Polyphosphate polymers are chains of phosphate monomers chemically
bonded together via phosphoanhydride bonds. They are found in all prokaryotic and
eukaryotic organisms and are among…

بواسطة Ajamaluddin Malik, Javed Masood Khan, Abdulaziz M. Al-Amri, Nojood Altwaijry, Prerna Sharma, Abdullah Alhomida, Priyankar Sen
publications

Phosphate additions in processed foods are a health risk that has been overlooked. This study examined the
effects of a permitted food additive (E452; Sodium Hexametaphosphate (SHMP)) on…

بواسطة Ajamaluddin Malik, Javed Masood Khan, Abdulaziz M. Al-Amri, Nojood Altwaijry, Abdullah S Alhomida, Mohammad Shamsul Ola
2023
publications

Protein aggregation is implicated in different human diseases. It also makes the protein less desirable candidate for industry as they exhibit reduced biological activity. Proteins tend to…

بواسطة Javed Masood Khan, Ajamaluddin Malik, Abdulaziz M. Al-Amri.
2023
تم النشر فى:
Journal of Molecular Liquids