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Alaa A.-M. Abdel-Aziz

Professor

Professor of Pharmaceutical Chemistry

كلية الصيدلة
Building 23, 2nd floor, Office 2A-114
المنشورات
مقال فى مجلة
2016
تم النشر فى:

Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibition activities and molecular docking study of pyrazoline derivatives

Abdel-Aziz, Maged A. Abdel-Sayed, Said M. Bayomi, Magda A. El-Sherbeny, Naglaa I. Abdel-Aziz, Kamal Eldin H. ElTahir, George S.G. Shehatou, Alaa A.-M. . 2016

Design, synthesis and pharmacological activities of a group of 1,3,5-trisubstituted pyrazolines were reported. The chemical structures of the synthesized compounds have been assigned on the basis of IR, MS, 1H NMR, and 13C NMR spectral analyses. The synthesized 1,3,5-trisubstituted pyrazoline derivatives were evaluated in vivo for anti-inflammatory, analgesic activities and in vitro for COX-1/2 inhibition assay. Among the tested compounds, derivatives 4h6e7a7e, and 9 showed more potent anti-inflammatory and analgesic activities than the reference drug celecoxib. On the basis of their higher activities in the in vivo studies compared with celecoxib, the five compounds4h6e7a7e and 9 were selected to test their inhibitory activities against ovine COX-1/2 using an in vitro cyclooxygenase inhibition assay. Docking study of compounds 7a7eand 9 into the COX-2 binding site revealed a similar binding mode to SC-558, a selective COX-2 inhibitor.

نوع عمل المنشور
Original Research Article
رقم المجلد
24
رقم الانشاء
Issue 9
الصفحات
2032-2042
مزيد من المنشورات
publications

We report a panel of carboxylates and sulfonamides incorporating phthalic anhydride and phthalimide moieties in their structure and their interaction with the metalloenzyme carbonic anhydrase (CA…

بواسطة Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Rezk R. Ayyad, Mariangela Ceruso, Claudiu T. Supuran
2016
publications

A novel series of 2-[(3-substituted-4(3H)-quinazolin-2-yl)thio]-N-(3,4,5-trimethoxyphenyl)acetamide (1521) and 3-[(3-substituted-4(3H…

بواسطة Menshawy A. Mohamed, Rezk R. Ayyad, Taghreed Z. Shawer, Alaa A.-M. Abdel-Aziz, Adel S. El-Azab
2016
publications

Design, synthesis and pharmacological activities of a group of 1,3,5-trisubstituted pyrazolines were reported. The chemical structures of the synthesized compounds have been assigned on the basis…

بواسطة Maged A. Abdel-Sayed, Said M. Bayomi, Magda A. El-Sherbeny, Naglaa I. Abdel-Aziz, Kamal Eldin H. ElTahir, George S.G. Shehatou, Alaa A.-M. Abdel-Aziz
2016