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Dr. ABDULAZIZ MOHAMMED ALAMRI

Demonstrator

BSc in Biochemistry, MSc and Ph.D. in Immunology, Biochemistry Department. College of Science, King Saud University

كلية العلوم
Office Address: Building 5 / Office : 2 A 60
المنشورات
فرضية
2016

A Role of Semaphorin-3E in Regulating Natural Killer Cell Migration in Natural Killer Cell – Dendritic Cell Crosstalk

, Abdulaziz Alamri . 2016

Semaphorin-3E (Sema-3E) is a member of the Semaphorin family that plays important regulatory roles in nervous and immune system.  Natural Killer (NK) and dendritic cells (DC) are immune cell types that mediate/shape innate and adaptive immunity.  The role of Sema-3E in regulating NK cell biology has not been reported.   
    first, we demonstrated that IL-2 activated NK cells expressed Sema-3E receptors on cell surface.  we compared NK migratory responses towards conditioned media of DC (immature, LPS- or Poly I:C stimulated) derived from Sema-3E+/+ or Sema-3E-/- mice.  Of interest, we observed that activated NK cells exhibited a two-fold increase in the migrations toward immature Sema-3E -/- DC conditioned medium when compared to that of the immature Sema-3E+/+ DC.  Our work revealed a novel role of Sema-3E in limiting NK-cell migrations toward immature DC in NK-DC crosstalk.   Future delineations of the impact and signaling of the Sema-3E pathway in NK-DC crosstalk may support novel development of immunotherapy for cancer and infectious diseases.   

نوع عمل المنشور
MASTER
مدينة النشر
Winnipeg
نوع الفرضية
Master Thesis
المدرسة
University of Manitoba
مزيد من المنشورات
publications

Cerebrovascular disease is a threat to people with diabetes and hypertension. Diabetes can damage the
brain by stimulating the renin-angiotensin system (RAS), leading to neurological…

بواسطة Abeeb Oyesiji Abiodun a , Dalia I AlDosari a , Amani Alghamdi a , Abdul Aziz Al-Amri a , Sarfaraz Ahmad b , Mohammad Shamsul Ola
2023
تم النشر فى:
Saudi Journal of Biological Sciences
publications

Abstract

بواسطة Shareefa A. AlGhamdi, Fahad A. Al-Abbasi, Amira M. Alghamdi, Asma B. Omer, Obaid Afzal, Abdulmalik S. A. Altamimi, Abdulaziz Alamri, Sami I. Alzarea, Waleed Hassan Almalki and Imran Kazmi
2023
تم النشر فى:
Royal Society
publications

Abstract
Background: Ovarian cancer leads to devastating outcomes, and its treatment is highly
challenging. At present, there is a lack of clinical symptoms and well-known sensitivity…

بواسطة Mohd Shahnawaz Khan, Nojood Altwaijry, Nasimudeen R. Jabir, Abdulaziz Mohammed Alamri, Mohammad Tarique, Azhar U. Khan4
2023
تم النشر فى:
Springer Nature