Quiz
 Answer ALL the following questions. 1. The following data was obtained from a bolus intravenous injection ofantibiotic to a patient weighting 70 kg at a dose of 37.55 mg. Time (hr)                                Plasma Conc. (μg/ml) 0.5                                                     1.75 0.8                                                     1.6 2.0                                                     1.2 3.0                                                     0.93 4.0                                                     0.72 6.0                                                     0.44 8.0                                                     0.22 10.0                                                    0.165 Plot the plasma conc. Of the drug versus time on two-cycle semi log. paper. a. Estimate the 1t 2 of the drug, d k and o C b. Estimate the total area under the plasma drug conc.-time curve. c. Calculate the volume of distribution. d. What will be the amount of drug remaining in the body after 7 hrs? _____________________________________________________________________ 2. A 60 kg man was given a single IV dose of a drug X at a dose 500 mg. Bloodsamples were taken at a various time. The following data were obtained. Time (hr)                                             Plasma Conc. (μg/ml) 1.0                                                              165 2.0                                                              136 3.0                                                              115 4.0                                                               95 6.0                                                              66.5 8.0                                                               46 10.0                                                            31.7 12.0                                                             22 a. Calculate and estimate the following: 1t 2 , d k , o C , d V b. Assuming the drug is no longer effective when levels decline to less than 50 mg/L. How many doses of the drug should this patient take every day? c. What will be the plasma level of the drug after 5 hrs? d. Predict what body water compartment this drug might occupy? And explain why you made this prediction.

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