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Quiz

Answer ALL the following questions.

1. The following data was obtained from a bolus intravenous injection ofantibiotic to a patient weighting 70 kg at a dose of 37.55 mg.

Time (hr)                                Plasma Conc. (μg/ml)

0.5                                                     1.75

0.8                                                     1.6

2.0                                                     1.2

3.0                                                     0.93

4.0                                                     0.72

6.0                                                     0.44

8.0                                                     0.22

10.0                                                    0.165

Plot the plasma conc. Of the drug versus time on two-cycle semi log. paper.

a. Estimate the 1t 2 of the drug, d k and o C

b. Estimate the total area under the plasma drug conc.-time curve.

c. Calculate the volume of distribution.

d. What will be the amount of drug remaining in the body after 7 hrs?

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2. A 60 kg man was given a single IV dose of a drug X at a dose 500 mg. Bloodsamples were taken at a various time. The following data were obtained.

Time (hr)                                             Plasma Conc. (μg/ml)

1.0                                                              165

2.0                                                              136

3.0                                                              115

4.0                                                               95

6.0                                                              66.5

8.0                                                               46

10.0                                                            31.7

12.0                                                             22

a. Calculate and estimate the following: 1t 2 , d k , o C , d V

b. Assuming the drug is no longer effective when levels decline to less than

50 mg/L. How many doses of the drug should this patient take every day?

c. What will be the plasma level of the drug after 5 hrs?

d. Predict what body water compartment this drug might occupy? And

explain why you made this prediction.

 

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