KSU Faculty Member websites > المعيد / احمد علي ناحي الغامدي > PHCL 461
 

                                          PHCL 461 - BASIC PHARMACOKINETIC (2+0)

 

Course Description

This course is designed to introduce the student to the changes in the drug's absorption, distribution and

elimination with time. One and two compartment models after different route of administration will be

discussed with their applications.

Course Objectives

Upon the completion of the course students will be able to:

1. Understand the basic pharmacokinetic principles.

2. Utilize these principles to determine certain pharmacokinetic parameters after various routeof administration.

3. Interpret the changes in drug level in the body withtime which lead to the impairment in its effect.

Course Contents Allocated and hours

1. Introduction

Complexity of the biological system 2

The need for compartmental models

The concept of comaprtments

2. One-Compartment Model

a) Intravenous Injection

- Drug levels in plasma and biologicalhalf-life. 1

- Apparent volume of distribution.Determination and applications. 1

- Area under the curve. Determinationand applications. 1

- Urinary excretion data. 1

- Drug clearance. Determination andapplications. 1

- Metabolites in plasma and urine. 1

b) Intravenous Infusion 4

- Drug levels in plasma during infusion,steady state, (at anytime after stoppinginfusion) applications.

- Relationship of elimination rate constant,half-life, drug clearance plasma level beforeand after steady-state levels.

- Simultaneous rapid intravenous injectionand infusion.

c) Extravascular Drug Administration 2

- Drug level post extravascular administrationfrom plasma data.

- Area under the curve

- Using urinary excretion data.

3. Two-Compartment Model 2

a) Intravenous injection

- Drug levels in plasma and biologicalhalf-life.

- Apparent volume of distribution.Determination and applications.

- Drug levels in tissue compartment

- Area under the curve. Determination andapplications.

- Urinary excretion data

- Drug clearance. Determination and applications

b) Intravenous infusion 2

- Drug levels in plasma during infusion,steady state, (at anytime after stoppinginfusion) applications.

- Relationship of elimination rate constant,half-life, drug clearance plasma level beforeand after steady-state levels.

- Simultaneous rapid intravenous injectionand infusion.

 

4. Application of Pharmacokinetic in Bioavailability 1

- Calculate the absorbed fraction

- Calculate relative and absolute bioavailability

- Bioequivalence

- Using urinary excreted data

5. Multiple Dose Therapy 2

- Calculate Cmax, Cmin and Cav.

- How to design therapy regimen.

6. Dosage Adjustment in Renal Disorder 2

- Calculate creatinine clearance

- Methods of dosage adjustment

7. Nonlinear Pharmacokinetics 3

- Saturated enzymatic elimination process

- Michaelis Mentin equation

- Determination of Km, Vmax

 

King   Saud University. All rights reserved, 2007 | Disclaimer | CiteSeerx