King Saud University
  Help (new window)
Search


Guidelines_English_Final
تحميل الدليل التدريبي

أسئلة شائعة


 

 

CURRICULUM VITAE

 

 

Dr. Hanan Hamdy Hagar

Associate Professor of Pharmacology, Department of Pharmacology

Medical College, King Saud University, Saudi Arabia

  

PERSONAL INFORMATION:

 

Name:                                          Hanan Hamdy Hagar.

Nationality:                                 Egyptian.

Sex:                                              Female.

Date of Birth:                             1-9-1966.

Place of Birth:                            Zagazig, Egypt.

Marital Status:                             Married (with three children).

Language:                                   English (Fluent) - Arabic.

E-mail :                            hananhhagar@yahoo.com

 

 

Current Address:                       Department of Pharmacology (31)

College of Medicine

King Saud University

PO Box 2925, Riyadh 11461   

Saudi Arabia

                                                             Phone: 00966-1-4786768 (work)

                                                                     

    Current Position:       Associate Professor of Pharmacology

    Specialization:              Renal and Cardiovascular Pharmacology

 

QUALIFICATION DEGREE AND SPECIALTY CERTIFICATION:

*      B.Sc. Pharmaceutical Sciences, Zagazig University, Zagazig, Egypt (1988).

*      M.S.  Pharmacology, Zagazig University, Zagazig, Egypt (1992).

*      Ph.D. Pharmacology, Zagazig University, Zagazig, Egypt with the University of Arkansas for Medical Sciences, Arkansas, USA (1997).

*      Associate Professor, Zagazig University, Zagazig, Egypt (2003).

*      Associate Professor, King Saud University, Saudi Arabia (2004).

 

B.Sc. PHARMACEUTICAL SCIENCES:

 

Courses: 

Physics, Physical Chemistry, Organic Chemistry, Botany, General  Pharmacognosy and Medicinal Plants, Inorganic Chemistry, Pharmaceutics, Analytical Chemistry, Anatomy, Histology, Physiology, Pharmacology. Biochemistry, Applied Pharmacognosy, Microbiology, Industrial Pharmacy, Bioassay of Drugs, Toxicology, Forensic, Biostatistics and First aids.

 

Grades:

              Preliminary year: very good

First year: Excellent (first of the class)

Second year: Excellent (first of the class)

Third year: Excellent (first of the class)

Fourth year: Excellent with honor (first of the class).

 

 

M. Sc. (PHARMACOLOGY):

 

Courses: Physical chemistry, Mathematics, Statistics, Industrial analysis.

Project: “Pharmacological studies on some possible interaction between lithium and captopril”.

 

Ph. D. (PHARMACOLOGY):

 

Project:  “Molecular studies on the mechanisms involved in renal tissue injury”.

 

ACADEMIC EXPERIENCES

Demonstrator:  Pharmacology Department-Faculty of Pharmacy-Zagazig University Zagazig-Egypt (1988 – 1992).                

Assistant Lecturer: Pharmacology Department-Faculty of Pharmacy-Zagazig

                                   University- Zagazig-Egypt (1992 - 1993).

Research Training: Research Training to obtain Ph. D. in Department of

                                    Nephrology, University of Arkansas for Medical Sciences,                                  Little Rock ansas, USA (1994 - 1996).

 

  Assistant Professor: Pharmacology Department-Faculty of Pharmacy-Zagazig

                                     University- Zagazig – Egypt (1997- 1999).                 

Assistant Professor:  Pharmacology Department- College of Medicine, King Saud

                                   University-Saudi Arabia (1999-2003).                                   

Associate Professor: Pharmacology Department-Faculty of Pharmacy- Zagazig

                                       University- Zagazig – Egypt (2003).

Current Position: Associate Professor- Pharmacology Department- College of Medicine,

    King Saud University- Saudi Arabia (2004-Untill).

TEACHING EXPERIENCES: 

Undergraduate courses

*      Teaching pharmacology for third year students, College of Pharmacy, Zagazig University, Zagazig, Egypt.

*      Teaching toxicology and bioassay for fourth year students, College of Pharmacy, Zagazig University, Zagazig, Egypt.

*      Teaching pharmacology courses PHL (231,232, 301) for second and third year students, College of Medicine, King Saud University, Kingdom of Saudi Arabia.

*      Teaching pharmacology course  PHL (411) for fourth year students, Dental College, King Saud University, Kingdom of Saudi Arabia.

*      Teaching pharmacology course PHL (366) for second year students, College of Allied Medical (nursing), King Saud University, Kingdom of Saudi Arabia.

*      Teaching pharmacology course (451) for second year students, College of Pharmacy, King Saud University, Kingdom of Saudi Arabia.

 

B) Postgraduate courses  

*       Teaching pharmacology course PHL (518) for postgraduate students,College of Pharmacy, King Saud University, Kingdom of Saudi Arabia. 

C) Supervision of Thesis:

Master Degree

1)      M.Sc. thesis entitledEffects of curcumin and valsartan on lead-induced hypertension and nephrotoxicity”. Faculty of Pharmacy, King Saud University, Kingdom of Saudi Arabia (2002-2004).

2)      MSc thesis entitled "Effects of advanced glycation end products inhibitors and/or statins on the progression of diabetic nephropathy in rats". Faculty of Pharmacy, King Saud University, Kingdom of Saudi Arabia (2004-2006).

 

LABORATORY EXPERIENCES:

*      Induction of renal hypertension (two kidney, one clip & one kidney, one clip renal hypertensive rats).

*      Measurement of arterial blood pressure

*      Determination of catecholamines and adenosine triphosphate (ATP).

*      Cannulation of different blood vessels in experimental animals.

*      Full experience with tissues cultures.

*      Isolation of DNA and RNA from tissues and cultured cells

*      Determination of DNA damage using agarose gel  electrophoresis and alkaline  unwinding assay in cultured cells

*      TUNEL technique in tissues.

*      Western blot analysis.

*      Northern blot analysis.

*      Determination of endonuclease activity using SDS polyacrylamide gel.

*      Measurement of cell death (LDH assay and trypan blue exclusion assay).

*      Determination of antioxidant enzymes (reduced glutathione, catalase, superoxide dismutase).

 

RESEARCH EXPERIENCES AND INTERESTS:

 

I have joined Dept of Nephrology, University of Arkansas for Medical Sciences where they have project focused on investigating the role of endonuclease activation in the occurrence of programmed cell death in isolated proximal tubules and cultured cells. During my PhD, I have investigated the role of endonuclease activation, reactive oxygen metabolites and calcium in the induction of apoptosis in cultured cells exposed to chemical hypoxia. After finishing my PhD, I investigated the role of tyrosine phosphorylation in the induction of DNA damage and cell death during chemical hypoxic injury to LLC-PK1 cells.

I am interested in investigating the role of reactive oxygen metabolites in the tissue damage to several organs including kidney, liver and brain induced by ischemia/reperfusion or by toxic chemical insults.

 

PROJECTS

 

A) As a principal investigator:

 

1) Project title: Effect of taurine against cyclosporine-induced hypertension and nephrotoxicity.

Funding institution: Research Center at Women Students-Medical Studies & Sciences Sections (1425H)

 

2) Project title: Modulation of leukocyte activation, platelet aggregation, and endothelial function by insulin-like growth factor-1 and statins in cerebral ischemia / reperfusion injury in diabetic rats.

Funding institution: KACST (1425 H)

Project number: MS-8-58

 

3) Project title: Effect of taming tumor necrosis factor- α (TNF-α) by selective phosphodiesterase IV inhibitors on nuclear factor (NF-kB), matrix metalloproteinases and extracellular matrix in renal ischemia / reperfusion injury in rats.

Funding institution: KACST (1426 H-1429H)

Project number: LP-24-43

 

4) Project title: Effect of blocking cysteinyl leukotriene receptors on lipopolysaccharide –induced multiple organ dysfunctions in rats.
 Funding institution: Research Center at Women Students-Medical Studies & Sciences Sections (1427 H).
                 

As a co- investigator:

 

1) Project title: Do advanced glycation end products inhibitors protect against experimentally induced liver fibrosis?
  Funding institution: Research Center at College of Medicine, King Saud University (1428 H).

  Project number: 07-572

 
 2) Project title: Evaluation of the possible protective effects of imipramine and fluvoxamine on ulcerative colitis induced experimentally in rats.
Fnding institution: Research Center at College of Medicine, King Saud University (1428 H).
Project number: 07-574

 

 

 MEMBERSHIP & PROFESSIONAL ORGANIZATION:

 

A membership of the following societies:

*      The Egyptian Society of Toxicology.

*      The Egyptian Pharmaceutical Society.

*      The Egyptian Society of Pharmacology and Experimental Therapeutics.

*      Arabian Pharmacists Association.

*      The Egyptian Pharmacists Association.

*      The Saudi Pharmaceutical Association.

*      The Scientific Egyptian Society for protection against environmental pollution.

 

SEMINARS AND PRESENTATION:

 

*      Free radicals and Antioxidants (24 July 1998).

*      Pharmacology of peptidase inhibitors (15 March 2003).

 

TRAINING WORKSHOP

 

*      Attendance of the training workshop entitled (Handling of animals) held in animal house of University of Arkansas for Medical Sciences, Little Rock, Arkansas (1996).

 

*      Attendance of the training workshop on Molecular Genetics (DNA hybridization) held in Faculty of Science, Ain Shams University, Cairo, Egypt (24 -29 Oct. 1998).

 

*      Attendance of the training workshop entitled “Skills of instructional methods” held in College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia (6 Oct. 2002).

 

*      Attendance of the training workshop entitled “Assessments” held in College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia (27 Oct., 2002).

 

*      Attendance of the training workshop entitled “Computer aided learning programs for teaching and research” held in College of Pharmacy, King Saud University, Kingdom of Saudi Arabia (6-7 April 2003).

 

Reviewer

As invited reviewer for the following international journals

*      Acta Pharmacologica Sinica

*      Cell Biology International

*      Clinica Chimica Acta

*      Digestive Diseases and Sciences

*      Journal of Pharmacy and Pharmacology

*      Pesticide Biochemistry and Physiology

 

CONFERENCES

 

Attendance of the following meetings:

1)      The 2nd annual meeting of College of Pharmacy, Zagazig University, Zagazig, Egypt (3 October 1992).

2)      The28th annual meeting of the American Society of Nephrology, San Diego, California, USA (5-8 November 1995). 

3)      The meeting of the Egyptian Society of Toxicology, College of Pharmacy, Al Azhar University, Cairo, Egypt (1-3 April 1998).

4)      The meeting of Egyptian Society of Pharmacology and Experimental Therapeutics, Cairo, Egypt (1 October 1998).

5)      The international meeting of the Egyptian Society of Clinical Chemistry, Marriot Hotel, Cairo, Egypt (5-7 December 1998).

6)      The meeting of the Egyptian Pharmaceutical Society, Meridian Hotel, Cairo, Egypt (8 -10 December 1998).

7)      The 13th annual meeting of Saudi Heart Association, Riyadh Intercontinental Hotel, Riyadh, Saudi Arabia (22-24 January 2002).

8)      9th International Pharmaceutical Sciences, Riyadh, Kingdom of Saudi Arabia (17-21, December, 2006).

9)          7th International Saudi Pharmaceutical Conference, Alfaisaliah Hotel, Riyadh, Kingdom of Saudi Arabia (19-21, March, 2007).

 

SCIENTIFIC SYMPOSIUMS

 

Attendance of the following symposiums:

*      Drugs, the case and the solution. Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.

*      Aids. Faculty of Pharmacy, Zagazig University, Zagazig, Egypt (21/10/1997).

*      Endothelium and the endothelium-derived relaxing factors. Faculty of pharmacy, Zagazig University, Zagazig, Egypt, (March 1998).

*      Recent advances in the treatment of diabetes. Sharkeia club, Zagazig, Egypt- (17/3/1999).

*      Return to Nature. College of Pharmacy, Zagazig University, Zagazig, Egypt- (20/3/1999).

*      Drugs education. College of Medicine, King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia (17-27/10/2000).

*      Heart health. College of Medicine, King Khalid University, Riyadh, Kingdom of Saudi Arabia (11-16/11/2000).

*      Natural products, Advantages and disadvantages. Medical Studies and Science Departments for Girls, Riyadh, Kingdom of Saudi Arabia (26-28/9/2001).

*      International symposium about Islamic Youths, King Abd. El. Aziz Library, Riyadh, Kingdom of Saudi Arabia (17-20/3/2002).

*      International Day of Diabetes. King Abd-El-Aziz Hospital, Riyadh, Kingdom of Saudi Arabia (10-11/11/2001).

*      Islamic and Civilizations Conversations. King Abd-El-Aziz Library, Riyadh, Kingdom of Saudi Arabia (17-20/3/2002).

*      The 7th symposium for medical studies and sciences departments for Girls-Recent techniques and its effect on human being and the environments. Riyadh, Kingdom of Saudi Arabia (1-3/4/2002).

 

LECTURES:

Attendance of the following lectures

*      A lecture entitled “The nation future and the need for scientific advances” for Dr. Ahmed Zeuil-Intercontinental, Riyadh, Kingdom of Saudi Arabia (15/10/2000).

*      Lecture entitled “Educational and social changes in Youth”. King Abd-El-Aziz Library, Riyadh, Kingdom of Saudi Arabia (12/2/2001).

*      Lecture entitled “Radiation around us”. Medical studies and sciences Departments for girls. Riyadh, Kingdom of Saudi Arabia (17/2/2001).

*      Lecture entitled “Synthesis of C-glycosides based therapeutics”. By Prof. Robert Lynhart-Medical studies and sciences departments, Riyadh, Kingdom of Saudi Arabia (17/2/2002).

*      Lecture entitled “Standardization of examination”. By Prof Sultan Faroukey the head of Pakistan Medical College King Khalid Hospital, Riyadh, Kingdom of Saudi Arabia (11/11/2001).

*      Lecture entitled “Osteoporosis and dental health”. Dental College, Kingdom of Saudi Arabia (10/4/2002).

*      Lecture entitled “Bringing out the best in medicine”. By Prof Tore K Kvien, the head of Department of Rheumatology, University of Oslo, Norway, College of Medicine, King Khalid Hospital, Riyadh, Kingdom of Saudi Arabia (11/11/2001).

*      Establishment of embryonic stem cells and its use. Medical Studies and Science Departments for Girls, Riyadh, Kingdom of Saudi Arabia (11/3/2007).

 

ABSTRACTS:

Participation in the following meetings:

1)      Endonuclease induced DNA damage and cell death in chemical hypoxic injury to LLC-PK1 cells.  28th annual meeting of the American society of Nephrology, San Diego-California- (5-7 / 11 / 1995).

 

2)      Effect of melatonin on gentamycin- induced oxidative stress and nephrotoxicity. The 26th annual meeting of the Egyptian pharmaceutical sciences, Meridian Hotel. Cairo, Egypt (8-10 / 12 / 1998).

 

3)      Folic acid and vitamin B12 supplementation attenuates   isoprenaline-induced myocardial infarction in experimental hyperhomocysteinemic rats. The 13th scientific session of the Saudi Heart Association, Riyadh Intercontinental Hotel, Riyadh, Kingdom of Saudi Arabia (22-24, 1/2002).

 

4)      Evaluating the prophylactic potential of zafilurkast against the toxic effects of acetic acid on the rat colon. 7th Saudi Gastroenterology Association Meeting, King Fahad Hospital, Riyadh, Kingdom of Saudi Arabia (1-3 /10 / 2002, Poster).

 

5)      The in vivo and in vitro anti-oxidant activity of ghrelin: Attenuation of gastric ischemic injury in the rat. (APDW 2005) Asian Pacific Digestive Week 2005 COEX Center, Seoul, Korea (25-28/9/2005, Oral presentation).

 

6)      Taurine attenuates hypertension and renal dysfunction induced by cyclosporine A in rats. 9th International Pharmaceutical Sciences, Riyadh, Kingdom of Saudi Arabia (17-21, December, 2006, Poster).

 

7)      Attenuation of bleomycin-induced lung fibrosis in rats by mesna. 9th International Pharmaceutical Sciences, Riyadh, Kingdom of Saudi Arabia (17-21, December, 2006, Poster).

 

8)      Effect of pyrrolidine dithiocarbamate on experimental colitis in rats. 9th International Pharmaceutical Sciences, Riyadh, Kingdom of Saudi Arabia (17-21, December, 2006, Oral presentation).

 

9)      Leukotriene receptor blocker, zafirlukast attenuates lipopolysaccharide-induced multiple organ dysfunction in rats. 7th International Saudi Pharmaceutical Conference, Alfaisaliah Hotel, Riyadh, Kingdom of Saudi Arabia (19-21, March, 2007, Poster). (This poster was donated the second prize of the meeting).

 

10)  Attenuation of thioacetamide-induced liver fibrosis by aminoguanidine. 7th International Saudi Pharmaceutical Conference, Alfaisaliah Hotel, Riyadh, Kingdom of Saudi Arabia (19-21, March, 2007, Poster).

                                            

PUBLICATION

 

1-        Rasha H. Abdel-Ghany, Mohamed N. Zakareia, Salah A. Ghareib and Hanan Hagar: Does lithium modulate the antihypertensive action of captopril in renal hypertensive rats?  Egypt. J. AppL. Sci. 7 (3) : 370-380, 1992.

 

2-        Mohamed N. Zakareia Rasha H. Abdel-Ghany; Salah A. Ghareib and Hanan Hagar: Effect of lithium, captopril and their combination on blood pressure of normotensive rats:  A contribution to the mechanism of action of lithium on blood pressure. Egypt.  J.  AppL.  Sci. 7 (3): 381-394, 1992.

 

3-         Hanan H. Hagar, Norishi Ueda, and Sudhir V. Shah: Endonuclease induced DNA damage and cell death in chemical hypoxic injury to LLC-PK1 cells.  Kidney International, 49: 355-361, 1996.

 

4-         Hanan H. Hagar, Norishi Ueda and Sudhir V. Shah: Tyrosine phosphorylation in DNA damage and cell death in hypoxic injury to LLC- PK1 cells. Kidney International, 51: 1747-1753, 1997.

 

5-        Hanan H. Hagar, Norishi Ueda and Sudhir V. Shah: Role of reactive oxygen metabolites in DNA damage and cell death in chemical hypoxic injuny to LLC PK cells. American Journal of Physiology, 271: F209-F215, 1996.

 

6-        Ahmed F. Ahmed, Mohamed N Zakeria, Nabila N. El-Maraghy and Hanan H. Hagar: Role of calcium chelators in DNA damage and cell death induced by chemical hypoxic injury in renal tubular epithelial cells. Under publication.

 

7-        Hanan H. Hagar, Sahar E. El-Swefey, S. and Atef S. Gharabawy: Protective effect of melatonin against gentamycin- induced oxidative stress and nephrotoxicity. The New Egyptian Journal of Medicine. 19 (5) : 271-278, 1998.

 

8-        Hoda, E. Mohamed and Hanan H. Hagar: Renal ischemia-reperfusion injury Contribution of nitric oxide and reactive oxygen species. The New Egyptian Journal of Medicine. 20 (3) : 147-154,1999.

 

9-        Hoda, E.  Mohamed, Sahar  E.El-Swefey, and  Hanan H. Hagar:  The  protective  effect  of  glutathione administration on adriamycin-induced acute cardiac toxicity in rats. Pharmacological Research. 42 (2): 115-121, 2000.

 

10-      Hanan H. Hagar, Mervat Asskar and Atef S. Gharabawy:  Effect of melatonin on acetaminophen-induced oxidative stress and hepatotoxicity. Zagazig University Medical Journal, 6 (6): 451-466, 2000.

 

11-     Ebtisam A. Ahmed and Hanan H. Hagar: Endothelial dysfunction in ovariectomized rats: Role of estrogen on nitric oxide and angiotensin converting enzyme. Zagazig University Medical Journal, 6 (7): 177-199, 2000.

 

12-     Hanan H. Hagar and Azza H. Fahmy: A biochemical, histochemical and ultrastructural evaluation of the effect of dimethoate intoxication on rat pancreas. Toxicology letters, 133 (2-3): 161-170, 2002.

 

13-          Hanan H. Hagar: Folic acid and vitamin B12 supplementation attenuates   isoprenaline-induced myocardial infarction in experimental hyperhomocysteinemic rats. Pharmacological Research, 46 (3): 213 - 219, 2002.

 

14-         Azza H. El Medany and Hanan H. Hagar: Effect of fluconazole on the fertility of male rabbits. Arzeneimittel–Forschung / Drug Research, 52 (8): 636-640, 2002.

 

15-         Afaf M. Maghoub, Azza H. El Medany, Hanan H. Hagar and Dorea M. Sabah : Protective effect of natural honey against acetic acid- induced colitis in rats.  Tropical Gastroenterology, 23: 82- 87, 2002.

 

16-         Afaf M. Maghoub, Azza H. El Medany, Hanan H. Hagar, Ali A Mustafa and Dorea M. Sabah: Evaluating the prophylactic potential of zafilurkast against the toxic effects of acetic acid on the rat colon. Toxicology Letters 14: 79 – 87, 2003.

 

17-         Azza H. El Medany, Hanan H. Hagar, Faten A.Zakaria: Cardioprotective effects of ATP sensitive potassium channel opener, nicorandil and the long acting potassium channel opener KRN 4884 in ischemic reperfused isolated rabbit’s heart. Saudi Pharmaceutical Journal, 11 (3): 77 – 86, 2003.

 

18-         Hanan H. Hagar: The protective effect of taurine against cyclosporine A- induced oxidative stress and hepatotoxicity in rats. Toxicology Letters, 151: 335-343, 2004.

 

19-         Azza El-Medany , Hanan H Hagar, Mahmoud Moursi, Raeesa A.Muhammed, Fatma El-Rakhawy, Gamila El-Medany. Attenuation of bleomycin– induced lung fibrosis in rats by mesna. Eur J of Pharmacol 9: 61-70, 2005.

 

20-         Eman El Eter, Hanan H Hagar, Ali Al-Tuwaijiri, Maha Araf. NF-кB inhibition by pyrrolidine dithiocarbamate attenuates gastric ischemia/ reperfusion injury in rats. Can J Physiol Pharmacol  83: 1-10; 2005.

 

21-         Hanan H Hagar, Eman El Etter, and Maha Arafa. Taurine attenuates hypertension and renal dysfunction induced by cyclosporine in rats. Clinical and Experimental Physiol and Pharmacol 33,189-196, 2006.

 

22-         Ali Mustafa, Azza El-Medany, Hanan H Hagar, Gamila El-Medany. Ginkgo biloba attenuates mucosal damage in a rat model of ulcerative colitis. Pharmacol Res 53: 324-330, 2006.

 

23-         Eman El Eter, Hanan H Hagar, Ali Al-Tuwaijiri, Maha Araf. The in vivo and in vitro anti-oxidant activity of ghrelin: Attenuation of gastric ischemic injury in the rat. J Gastroenterology and Hepatology, 2006 1440-1746, 2006.

 

24-         Hanan H Hagar, Azza El-Medany, Eman El Eter, and Maha Araf. Ameliorative effect of pyrrolidine dithiocarbamate on acetic acid-induced colitis in rats. Eur J of Pharmacol 554: 69-77, 2007.

 

25-         Hanan H Hagar. Leukotriene receptor blocker, zafirlukast ameliorates lipopolysaccharide- induced multiple organ dysfunction in rats. Under submission.

 

26-         Hanan H Hagar, Eman ElEter and Raeesa Abd El Tawab. Leukotriene receptor blocker, zafirlukast protects against ischemia/reperfusion injury in rats. Under submission.

 

27-         Hanan H Hagar. Role of resveratrol in cisplatin-induced nephrotoxicity in rats. Under submission.

 

 

 

       

 
King   Saud University. All rights reserved, 2007 | Disclaimer | CiteSeerx