Course Number and Symbol: Chem. 106 2(2+0)
Course Name: Organic Chemistry-for Health Sciences
Specific course aims at providing the student in the Health Sciences with the basic concepts of organic chemistry relevant to their further studies.
a) Alkanes and Cycloalkanes (4 lectures)
Sp3–hybridization, nomenclature (common, IUPAC), physical properties (boiling points, solubility, sources, synthesis ( in out line only), reaction (oxidation and free radical halogenation (no mechanism required).
b)Alkenes and Cycloalkenes(4 lectures)
Sp2–hybridization, nomenclature (common, IUPAC), physical properties (boiling points, solubility), synthesis [dehydrohalogenation of alkyl halides, dehydration of alcohols], reaction [halogenations, hydrogenation, addition of hydrogen halides, halohydrin formation, oxidation, epoxidation, ozonololysis].
c)Alkynes and Cycloalkynes(2 lectures)
Sp–hybridization, nomenclature(common, IUPAC), physical properties (boiling points, solubility), sources, synthesis [from CaC2, dehydrohalogenation of alkyl halides, from sodiumacetylides], reaction [hydrogenation, addition of HX, H2O, X2].
2-Benzene and aromatic compounds (3 lectures):
Structure and stability of benzene, aromatic character, Nomenclature, reactions [aromatic( halogenations, alkylation's, nitration, sulphonation) and side chain (halogenations of alkyl side chain, oxidation )
3-Halogen containing compounds (2 lectures):
Classification, nomenclature(common, IUPAC), physical properties (boiling points, solubility),synthesis [halogenations of alkanes, addition of HX to alkenes and alkynes, from alcohol( SOCl2 , PX3, PX5)], reactions(nucleophilic substitution, elimination, grignards reagent, reduction by metal and acids)
4-Oxygen containing compounds
a) Alcohol, Phenol, Ether, Epoxides (7 lectures)
Classification, structure, nomenclature(common, IUPAC), physical properties (solubility, hydrogen bonds, b.pts), synthesis of alcohols( review from alkenes and alkyl halides , Grignard reagent with aldehyde , ketone and esters, reduction of aldehyde, ketones , acids and esters). Synthesis of phenols ( hydrolysis of diazonium salt, alkali fusion, of sodium benzenesulfonates). Synthesis of ether ( dehydration of alcohols , William synthesis of epoxide, synthesis from alkenes and alcohol , reaction of alcohols( salt formation, oxidation, ester formation) reaction of phenol(salt formation, oxidation, ester formation), reaction of ethers(with HI, reaction of epoxide(three member ring ) with H2O, ROH, HX, LiAlH4, phenol, Grignard reagent.
b) Aldehyde and ketones (3 lectures)
Structure, nomenclature (common, IUPAC), physical properties (solubility, b.pts), synthesis [ oxidation of alcohols, ozonolysis of alkenes, hydration of alkynes, hydrolysis of alkyl dihalides], reaction of aldehyde and ketones [ rection of carbonyl compounds, addition of Grignard reagent, addition of alkynide ions, addition of HCN(hydrolysis of the product), addition of alcohol,(hemiacetal, cital, hemiketal, and ketal formation, no mechanism , addition of ammonia and it's derivatives, synthesis of amino acids , acidity of aldehaydes and ketones, aldol condensation.
c) Carboxylic acids and it's derivatives (7 lectures)
Structure, nomenclature (common, IUPAC), physical properties (solubility, b.pts), synthesis [ oxidation of aldehyde], carbonation of Grignard reagent, hydrolysis of nitrile, and carbonation of acetylide ion, reaction of carboxylic acid( salt formation, formation of acid derivatives: acid chloride, acid anhydride, amide, ester. Reaction of acid derivatives [elimination reaction, hydrolysis of acid chloride, ester, reaction with acid chloride, acetylation , reduction.
5-Nitrogen-contaning compounds (2 lectures)
Classification, structure, nomenclature(common, IUPAC), physical properties (solubility, hydrogen bonds, b.pts), basicity of aliphatic amine and aniline, quaternary ammonium salt, synthesis, of amines[ reduction of nitro, nitrile, oxime, amide, alkylation of ammonia], reaction [ salt formation, alkylation, reaction with nitrous acid, amide formation.
distribution of marks
Exam. I after 6 weeks………. 25
Exam. II after 11 weeks……….. 25
Final Exam. ………………….. 50