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تحميل الدليل التدريبي

أسئلة شائعة


 

CURRICULUM VITAE

 

 

Name:                          Mohamed Mohamed Sayed-Ahmed

                                                           

 

MAILING ADDRESS:         Pharmacology and Experimental Oncology Unit, National Cancer Institute, Kaser El-Aini St., Foum El-Khalig, Cairo, Egypt.

                                                FAX.           002023644720

                                                Home Tel.  002024900159

                                                                    002024916028

                                                Mobile.       0020101720659

                                                e.mail: mmsayedahmed@hotmail.com

 

DATE OF BIRTH:                 09/03/1962

 

SEX:                                       Male.

 

NATIONALITY:                   Egyptian.

 

MARITAL STATUS:            Married to Dr. Amira Zakzouk in 1992.  Have Two Children, Walaa and Ahmed Mohamed Sayed-Ahmed

 

LANGUAGES:                      Arabic and English.

 

 

EDUCATION:

 

1980-1985                               B. Pharmaceutical SC. Hon., Zagazig Faculty of Pharmacy.

 

1988-1992                               Master of  Pharmacology and Experimental Oncology, Faculty of Pharmacy, Cairo University. Thesis: Effect of local Hyperthermia and some Anticancer       drugs in the treatment of Solid Ehrlich Carcinoma.

 

1992-1995                               Ph.D. Pharmacology and Experimental Oncology, National Cancer Institute, Cairo University.Thesis: Pharmacological and Biochemical Studies on the Mechanisms of Adriamycin Induced-Cardiotoxicity.

EMPLOYMENT RECORDS:

 

1988-1992:                              Demonstrator of Pharmacology and Experimental Oncology, Cancer Biology Department, National Cancer Institute, Cairo University.

 

1992-1997:                              Assistant Lecturer of Pharmacology and Experimental

Oncology, Cancer Biology Department, National Cancer Institute, Cairo University.

 

1994-1997:                              Ph.D student at Duke University, Medical Center, USA.

 

1997-2002:                              Lecturer of Pharmacology and Experimental Oncology, Cancer Biology Department, National Cancer Institute, Cairo  University.

 

2002-2007:                              Assistant Professor of  Pharmacology and Experimental Oncology, Cancer Biology Department, National Cancer Institute, Cairo  University.

 

2004-Now:                              Associate Professor of  Pharmacology, Pharmacology Department, College of Pharmacy, King Saud University, Kingdom Saudi Arabia.

 

2007-Now:                              Professor of  Pharmacology and Experimental Oncology, Cancer Biology Department, National Cancer Institute, Cairo  University.

 

 

TEACHING EXPERIENCES:

1- Teaching experience  in pharmacology and Toxicology for undergraduate

students at 6Th  of  October Faculty of Pharmacy, Cairo, Egypt.

 

2- Teaching experience in Toxicology, Pharmacology and Experimental Oncology for

Postgraduate students, National Cancer Institute, Cairo University.

 

3- Teaching experience in Pharmacology and Toxicology for Postgraduate students,

Faculty of pharmacy, Ain Shams University

 

4- Teaching experience in Clinical pharmacology and Toxicology for Clinical Pharmacy

 Students at National Cancer Institute, Cairo University.

 

5- Teaching experience in Toxicology, Pharmacology and Experimental Oncology for

M.D. student, South Egypt Cancer Institute, Assuit University.

 

6- Experience in Teaching Rotation Laboratories for M.D. and Ph.D. students, National Cancer Institute, Cairo University.

 

 

7- Teaching experience in Clinical pharmacology and Toxicology, Pharmacology

 Department, College of Pharmacy, King Saud University, Kingdom Saudi Arabia.

 

 

 

 

 

 

RESEARCH EXPERIENCES:

 

1- Research Experience in using L-carnitine and Propionyl-l-carnitine as protective

agents against Anticancer drug-induced organs toxicity.(Duke University, Medical Center, USA).

 

2- Research Experience in modulation of Anticancer drugs-induced organ toxicity.

(Duke University, Medical Center, USA).

 

3- Research Experience in study the effects of anticancer drugs on cardiac and hepatic

metabolism using isotopic dilution technique (Duke University,Medical Center, USA).

 

4- Research Experience in isolation of Cardiac myocytes and liver hepatocytes as

toxicity model to study radioactive substrate oxidation in response to anticancer drugs (Duke University, Medical Center, USA).

 

5- Research Experience in modulation of tumour cell drug resistance and in tissue culture Technique dealing with the growth of human tumour cells, tumour cell cycle phase determination using flowcytometery.       

 

6- Good experience in screening the potentially antiangiogenic and antimetastatic agents as biological therapy of cancer and in screening anticancer agents and the interaction between anticancer drugs and other drugs using different tumour cell lines.

 

7- Good experience in using HPLC technique for determination of plasma level of

anticancer drugs, Antibiotics, Narcotics, and L-carnitine as a routine used for the treatment and follow up of Egyptian Cancer Patients.(Therapeutic drug monitoring).

    

List of  Publications

1- Osman, A. M. ; Sayed-Ahmed, M. M. ; Khayyal, M. T. and El-    Merzabani, M. M.:  Hyperthermic Potentiation of Cisplatin on Solid Ehrlich Carcinoma.  Tumori 1993, 79:  268-272.

2- Shouman, S. A.; Sayed-Ahmed, M. M. and El-Merzabani, M.M:  Potentiation of the Chemotherapeutic Effect of             Methotrexate by Hyperthermia in Experimental Animal Tumour Model. J. Egypt. Nat. Cancer Inst. 1994 , 6:  868-876.

3- Abdel-aleem, S. ; Sharawi, S. ; Badr, M. ; Sayed-Ahmed, M. M. ; Anstadt, M. P. and

Lowe, J.E.:  Reduced Induction of       Carbohydrate Utilization by Inhibition of Fatty Acid Oxidation in Myocytes From Diabetic Animals. Horm. Metab. Res. 1994, 27:  104-106.

4- Abdel-aleem, S. ; Sayed-Ahmed, M. M. ; Nada, M. A. ;   Hendrickson, S. C. ; Louis, J. S. and Lowe, J.E.:  Stimulation of Non-Oxidative Glucose Utilization by

L-carnitine in Isolated Myocytes. J. Mol. Cell. Cardiol. 1995, 27: 2465-2472.

5- Abdel-aleem, S. ; Sayed-Ahmed, M. M. ; Nada, M. A. ;   Hendrickson, S. C. ; Louis, J. S., Walthhall, H.P. and Lowe, J.E.:  Regulation of Fatty Acid Oxidation by Acetyl-CoA Generated From Glucose Utilization in Isolated Myocytes.

J. Mol. Cell. Cardiol. 1996, 28:  825-833.

6- Abdel-aleem, S. ; El-Merzabani, M. M. ; Sayed-Ahmed, M. M. ; Taylor, D. A.

 and Lowe, J. E.:  Acute and Chronic Effects of Adriamycin on Fatty Acid Oxidation in Isolated Cardiac Myocytes.  J. Mol. Cell. Cardiol. 1997, 29:  789-797.

 

7 - Abidli, N., Sayed-Ahmed, M.M., El-Gerzawy,S.M.,El-Didi, M.M.           Benlatreche,C.,El-Merzabani,M.M. and Osman,A.M: Verapamil

 enhancement of the cytotoxic and cell cycle perturbation of doxorubicin in Ehrlich ascites carcinoma cells in vivo. 

            J. Egyptian National Cancer Institute 1999; 10: 433-438.

8- Sayed-Ahmed, M.M. ,Sharawy, S.,Shouman,S.A. And Osman,A.M..: Reversal

of doxorubicin-induced cardiac metabolic damage by l-carnitine.  Pharmacol. Res. 1999, 39: 289-295.

9- Sayed-Ahmed, M.M., Khattab, M., Khalifa, A., El-Khabany, M. and Osman, A.M: Potenial promise of using L-carnitine and Coenzyme Q10 as protective agents against Cisplatin-induced nephrotoxicity. J. Egyptian National Cancer Institute 1999; 11: 167-173.

10-  Hanafy M., Sayed-Ahmed, M.M. and Osman A.M.:  The protective effect

of methimazole against cisplatin-induced chromosomal abberrations. Sc. J. Az. Med. Fac.(Girls) 1999, 20: 637-645.

11 - Sayed-Ahmed M.M., Shouman, S.A., Rezk, B.M., Khalifa,        M.H.,Osman, A.M.

and El-Merzabani, M.M: Propionyl-L-carnitine as potential protective agent against adriamycin-induced impairment of fatty acid beta-oxidation in isolated heart mitochondria. Pharmacol. Res. 2000, 41: 143-150.

12- Salman T.M. and Sayed-Ahmed M.M.:  Effects of trichloroactate,

 water chlorination by-product, on liver peroxisomes and antioxidant status in rats and mice. Sc. J. Az. Med. Fac.(Girls) 2000, 21: 631-648.

13- Osman,A.M. Mohamed M.A., Abdel-Wahab A.A.,and Sayed-Ahmed M.M.

        Modulation by verapamil of doxorubicin induced expression of  multidrug

        resistance gene (MDR-1 P-glycoprotein) in murine tumour mode. 

      J. Egyptian Nat. Cancer Inst. 2000; 12: 221-227.

14- Sayed-Ahmed MM, Kishk AM, Soloma S and Abdel-aleem S: Protection

       by L-carnitine against the inhibition of gene expression of heart fatty acid

       binding protein by chronic administration of doxorubicin. J. Egyptian Nat. Cancer

       Inst. 2000, 12:  275-281.

15-  A.M.Osman, H.Gaballa, N.H.Mohamed,N.M.Ali., M.M.Sayed-Ahmed,and H.

       M.Arafa : Plasma endothelin( ET-1) as a marker for doxorubicin-induced

       cardiotoxicity in Egyptian patients. J.Egypt Soc.Toxicol 2000; 23:  59-64.

16- Ramadan LA, El-Habit O, Arafa H and Sayed-Ahmed MM :  Effect of

       cremophor-El on cisplatin induced organs toxicity in normal rats.

       J. Egyptian Nat.   Cancer Inst. 2001, 13: 11-17.

17- Sayed-Ahmed, M.M., Salman T.M., Gaballah, H.E., Abo El-Nagah,

       S.A., Nicolia, R. and  Calvani, M.:  Propionyl-l-carnitine as protector against

      adriamycin-induced cardiomyopathy. Pharmacol. Res. 2001, 43:  513-520.

18- Ramadan LA, Shouman SA, Sayed-Ahmed Mmand El-Habit OH :

       Modulation of radiation induced organs toxicity by Cremophor-El in experimental

       animals. Pharmacol Res 2001, 43:  185-191.

19- Sayed-Ahmed M.M., Khattab M.M., Gad M.Z. and Osman A.M.:  Increased

       plasma endothelin-1 and cardiac nitric oxide during doxorubicin-

        inducedcardiomyopathy. Pharmacology & Toxicology 2001, 89:  140-144.

20- Sayed-Ahmed M.M. , Khattab M.M.,  Gad M.Z. and  Mostafa N.:  L-carnitine

         prevents the progression of Atherosclerotic lesions in hypercholesterolemic

         rabbits.  Pharmacol Res  2001; 44:  235-242.

21- Sayed-Ahmed M.M., Shouman S.A., and Ramadan L.A.: Contribution of nitric

       oxide in doxorubicin-related cytotoxicity in murine tumour model.

       J Egyptian Nat Cancer Inst 2002; 14:  111-116.  

22- Arafa H.M. and Sayed-Ahmed M.M.: Protective role of carnitine esters

       against alcohol-induced gastric lesions in rats.

       Pharmacol Res 2003;  48:  285-290.

 

23-  El-Demerdash E., Ali A.A., Sayed-Ahmed M.M. and Osman A.M.:  New

         aspects in probucol cardioprotection against doxorubicin-induced cardiotoxicity.

        Cancer  Chemother and Pharmacol  2003; 52:  411-416.

24- Sayed-Ahmed M.M., Eissa M.A., Kenawy S.A., Mostafa M., Calvani M. and

       Osman A.M.: Progression of cisplatin-induced nephrotoxicity in carnitine-

       depleted rat model. Chemotherapy 2004; 50:  162-170.

25- Sayed-Ahmed M.M., Mansour H.H., Gharib O.A. and Hafez F.H: 

       Acetyl-L carnitine Modulates bleomycin-induced oxidative stress and energy

       depletion in lung tissues.  J Egyptian Nat Cancer Inst 2004; 16:  237-243.

26- El-Demerdash E., Awad  A.S, Taha R.M,  El-Hady A.M., and Sayed-Ahmed

       M.M.  Probucol attenuates oxidative stress and energy decline in

       isoproterenol-induced congestive heart failure in rat.

       Pharmacol Res 2005;  51:  311-318.

27- Sayed-Ahmed M.M and Mohamed A. M.: Contribution of nitric oxide and

       epidermal growth factor receptor in antimetastatic potenial of paclitaxel in human

       liver cancer cells (Heb G2). J Egyptian Nat Cancer Inst 2005; 17:  35-41.

28-  Al-Majed A.A., Sayed-Ahmed M.M., Al-Yahya A.A., Aleisa A.M., Al-Rejaie S.S.

       Al-Shabanah O.A.  Propionyl-L-carnitine prevents the progression of cisplatin-

        induced cardiomyopathy in a carnitine-depleted rat model.

      Pharmacol Res 2006; 53:  278-286.

29- Al-Majed A.A., Sayed-Ahmed M.M.,  Al-Omar F.A., Al-Yahya A.A., Aleisa A.M.

       and Al-Shabanah O.A.:  Carnitine esters prevent oxidative stress damage and energy

       depletion following transient forebrain ischemia in the rat hippocampus. Clin  Exp

       Pharmacol Physiol 2006; 33:  725-733.

30- Sayed-Ahmed M.M. and Nagi M.N.  Thymoquinone supplementation prevents the

       development of gentamicin-induced acute renal toxicity in rats. Clin  Exp

       Pharmacol Physiol 2007; 34:  399-405.

31- Kamel M.W., Salama S.A., Saleh S., Osman A.M., Sayed-Ahmed M.M.,

      Al-Hendy A.  Reversal of doxorubicin resistance by adenovirus-mediated transfer of

      cyclooxygenase-2 antisense in multidrug-resistant MCF-7 cells.  Cancer Therapy

      2007; 5: 1-10.

32- Sayed-Ahmed MM:  Increased Serum and Cardiac Acyl-carnitine/Free Carnitine

      ratio During Development of  Doxorubicin-Induced Cardiotoxicity.

      Saudi Pharmaceutical Journal 2007: 15:  120-126.

33- Sayed-Ahmed MM: Multidrug resistance to cancer chemotherapy: Genes involved

       and blockers. Saudi Pharmaceutical Journal 2007: 15:  161-175.

 

 

 

 

 

 

           

 

 

 

 

           

                                   

 

 

 

 

 

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