Name: Mohamed Mohamed Sayed-Ahmed
MAILING ADDRESS: Pharmacology and Experimental Oncology Unit, National Cancer Institute, Kaser El-Aini St., Foum El-Khalig, Cairo, Egypt.
Home Tel. 002024900159
DATE OF BIRTH: 09/03/1962
MARITAL STATUS: Married to Dr. Amira Zakzouk in 1992. Have Two Children, Walaa and Ahmed Mohamed Sayed-Ahmed
LANGUAGES: Arabic and English.
1980-1985 B. Pharmaceutical SC. Hon., Zagazig Faculty of Pharmacy.
1988-1992 Master of Pharmacology and Experimental Oncology, Faculty of Pharmacy, Cairo University. Thesis: Effect of local Hyperthermia and some Anticancer drugs in the treatment of Solid Ehrlich Carcinoma.
1992-1995 Ph.D. Pharmacology and Experimental Oncology, National Cancer Institute, Cairo University.Thesis: Pharmacological and Biochemical Studies on the Mechanisms of Adriamycin Induced-Cardiotoxicity.
1988-1992: Demonstrator of Pharmacology and Experimental Oncology, Cancer Biology Department, National Cancer Institute, Cairo University.
1992-1997: Assistant Lecturer of Pharmacology and Experimental
Oncology, Cancer Biology Department, National Cancer Institute, Cairo University.
1994-1997: Ph.D student at Duke University, Medical Center, USA.
1997-2002: Lecturer of Pharmacology and Experimental Oncology, Cancer Biology Department, National Cancer Institute, Cairo University.
2002-2007: Assistant Professor of Pharmacology and Experimental Oncology, Cancer Biology Department, National Cancer Institute, Cairo University.
2004-Now: Associate Professor of Pharmacology, Pharmacology Department, College of Pharmacy, King Saud University, Kingdom Saudi Arabia.
2007-Now: Professor of Pharmacology and Experimental Oncology, Cancer Biology Department, National Cancer Institute, Cairo University.
1- Teaching experience in pharmacology and Toxicology for undergraduate
students at 6Th of October Faculty of Pharmacy, Cairo, Egypt.
2- Teaching experience in Toxicology, Pharmacology and Experimental Oncology for
Postgraduate students, National Cancer Institute, Cairo University.
3- Teaching experience in Pharmacology and Toxicology for Postgraduate students,
Faculty of pharmacy, Ain Shams University
4- Teaching experience in Clinical pharmacology and Toxicology for Clinical Pharmacy
Students at National Cancer Institute, Cairo University.
5- Teaching experience in Toxicology, Pharmacology and Experimental Oncology for
M.D. student, South Egypt Cancer Institute, Assuit University.
6- Experience in Teaching Rotation Laboratories for M.D. and Ph.D. students, National Cancer Institute, Cairo University.
7- Teaching experience in Clinical pharmacology and Toxicology, Pharmacology
Department, College of Pharmacy, King Saud University, Kingdom Saudi Arabia.
1- Research Experience in using L-carnitine and Propionyl-l-carnitine as protective
agents against Anticancer drug-induced organs toxicity.(Duke University, Medical Center, USA).
2- Research Experience in modulation of Anticancer drugs-induced organ toxicity.
(Duke University, Medical Center, USA).
3- Research Experience in study the effects of anticancer drugs on cardiac and hepatic
metabolism using isotopic dilution technique (Duke University,Medical Center, USA).
4- Research Experience in isolation of Cardiac myocytes and liver hepatocytes as
toxicity model to study radioactive substrate oxidation in response to anticancer drugs (Duke University, Medical Center, USA).
5- Research Experience in modulation of tumour cell drug resistance and in tissue culture Technique dealing with the growth of human tumour cells, tumour cell cycle phase determination using flowcytometery.
6- Good experience in screening the potentially antiangiogenic and antimetastatic agents as biological therapy of cancer and in screening anticancer agents and the interaction between anticancer drugs and other drugs using different tumour cell lines.
7- Good experience in using HPLC technique for determination of plasma level of
anticancer drugs, Antibiotics, Narcotics, and L-carnitine as a routine used for the treatment and follow up of Egyptian Cancer Patients.(Therapeutic drug monitoring).
List of Publications
1- Osman, A. M. ; Sayed-Ahmed, M. M. ; Khayyal, M. T. and El- Merzabani, M. M.: Hyperthermic Potentiation of Cisplatin on Solid Ehrlich Carcinoma. Tumori 1993, 79: 268-272.
2- Shouman, S. A.; Sayed-Ahmed, M. M. and El-Merzabani, M.M: Potentiation of the Chemotherapeutic Effect of Methotrexate by Hyperthermia in Experimental Animal Tumour Model. J. Egypt. Nat. Cancer Inst. 1994 , 6: 868-876.
3- Abdel-aleem, S. ; Sharawi, S. ; Badr, M. ; Sayed-Ahmed, M. M. ; Anstadt, M. P. and
Lowe, J.E.: Reduced Induction of Carbohydrate Utilization by Inhibition of Fatty Acid Oxidation in Myocytes From Diabetic Animals. Horm. Metab. Res. 1994, 27: 104-106.
4- Abdel-aleem, S. ; Sayed-Ahmed, M. M. ; Nada, M. A. ; Hendrickson, S. C. ; Louis, J. S. and Lowe, J.E.: Stimulation of Non-Oxidative Glucose Utilization by
L-carnitine in Isolated Myocytes. J. Mol. Cell. Cardiol. 1995, 27: 2465-2472.
5- Abdel-aleem, S. ; Sayed-Ahmed, M. M. ; Nada, M. A. ; Hendrickson, S. C. ; Louis, J. S., Walthhall, H.P. and Lowe, J.E.: Regulation of Fatty Acid Oxidation by Acetyl-CoA Generated From Glucose Utilization in Isolated Myocytes.
J. Mol. Cell. Cardiol. 1996, 28: 825-833.
6- Abdel-aleem, S. ; El-Merzabani, M. M. ; Sayed-Ahmed, M. M. ; Taylor, D. A.
and Lowe, J. E.: Acute and Chronic Effects of Adriamycin on Fatty Acid Oxidation in Isolated Cardiac Myocytes. J. Mol. Cell. Cardiol. 1997, 29: 789-797.
7 - Abidli, N., Sayed-Ahmed, M.M., El-Gerzawy,S.M.,El-Didi, M.M. Benlatreche,C.,El-Merzabani,M.M. and Osman,A.M: Verapamil
enhancement of the cytotoxic and cell cycle perturbation of doxorubicin in Ehrlich ascites carcinoma cells in vivo.
J. Egyptian National Cancer Institute 1999; 10: 433-438.
8- Sayed-Ahmed, M.M. ,Sharawy, S.,Shouman,S.A. And Osman,A.M..: Reversal
of doxorubicin-induced cardiac metabolic damage by l-carnitine. Pharmacol. Res. 1999, 39: 289-295.
9- Sayed-Ahmed, M.M., Khattab, M., Khalifa, A., El-Khabany, M. and Osman, A.M: Potenial promise of using L-carnitine and Coenzyme Q10 as protective agents against Cisplatin-induced nephrotoxicity. J. Egyptian National Cancer Institute 1999; 11: 167-173.
10- Hanafy M., Sayed-Ahmed, M.M. and Osman A.M.: The protective effect
of methimazole against cisplatin-induced chromosomal abberrations. Sc. J. Az. Med. Fac.(Girls) 1999, 20: 637-645.
11 - Sayed-Ahmed M.M., Shouman, S.A., Rezk, B.M., Khalifa, M.H.,Osman, A.M.
and El-Merzabani, M.M: Propionyl-L-carnitine as potential protective agent against adriamycin-induced impairment of fatty acid beta-oxidation in isolated heart mitochondria. Pharmacol. Res. 2000, 41: 143-150.
12- Salman T.M. and Sayed-Ahmed M.M.: Effects of trichloroactate,
water chlorination by-product, on liver peroxisomes and antioxidant status in rats and mice. Sc. J. Az. Med. Fac.(Girls) 2000, 21: 631-648.
13- Osman,A.M. Mohamed M.A., Abdel-Wahab A.A.,and Sayed-Ahmed M.M.
Modulation by verapamil of doxorubicin induced expression of multidrug
resistance gene (MDR-1 P-glycoprotein) in murine tumour mode.
J. Egyptian Nat. Cancer Inst. 2000; 12: 221-227.
14- Sayed-Ahmed MM, Kishk AM, Soloma S and Abdel-aleem S: Protection
by L-carnitine against the inhibition of gene expression of heart fatty acid
binding protein by chronic administration of doxorubicin. J. Egyptian Nat. Cancer
Inst. 2000, 12: 275-281.
15- A.M.Osman, H.Gaballa, N.H.Mohamed,N.M.Ali., M.M.Sayed-Ahmed,and H.
M.Arafa : Plasma endothelin( ET-1) as a marker for doxorubicin-induced
cardiotoxicity in Egyptian patients. J.Egypt Soc.Toxicol 2000; 23: 59-64.
16- Ramadan LA, El-Habit O, Arafa H and Sayed-Ahmed MM : Effect of
cremophor-El on cisplatin induced organs toxicity in normal rats.
J. Egyptian Nat. Cancer Inst. 2001, 13: 11-17.
17- Sayed-Ahmed, M.M., Salman T.M., Gaballah, H.E., Abo El-Nagah,
S.A., Nicolia, R. and Calvani, M.: Propionyl-l-carnitine as protector against
adriamycin-induced cardiomyopathy. Pharmacol. Res. 2001, 43: 513-520.
18- Ramadan LA, Shouman SA, Sayed-Ahmed Mmand El-Habit OH :
Modulation of radiation induced organs toxicity by Cremophor-El in experimental
animals. Pharmacol Res 2001, 43: 185-191.
19- Sayed-Ahmed M.M., Khattab M.M., Gad M.Z. and Osman A.M.: Increased
plasma endothelin-1 and cardiac nitric oxide during doxorubicin-
inducedcardiomyopathy. Pharmacology & Toxicology 2001, 89: 140-144.
20- Sayed-Ahmed M.M. , Khattab M.M., Gad M.Z. and Mostafa N.: L-carnitine
prevents the progression of Atherosclerotic lesions in hypercholesterolemic
rabbits. Pharmacol Res 2001; 44: 235-242.
21- Sayed-Ahmed M.M., Shouman S.A., and Ramadan L.A.: Contribution of nitric
oxide in doxorubicin-related cytotoxicity in murine tumour model.
J Egyptian Nat Cancer Inst 2002; 14: 111-116.
22- Arafa H.M. and Sayed-Ahmed M.M.: Protective role of carnitine esters
against alcohol-induced gastric lesions in rats.
Pharmacol Res 2003; 48: 285-290.
23- El-Demerdash E., Ali A.A., Sayed-Ahmed M.M. and Osman A.M.: New
aspects in probucol cardioprotection against doxorubicin-induced cardiotoxicity.
Cancer Chemother and Pharmacol 2003; 52: 411-416.
24- Sayed-Ahmed M.M., Eissa M.A., Kenawy S.A., Mostafa M., Calvani M. and
Osman A.M.: Progression of cisplatin-induced nephrotoxicity in carnitine-
depleted rat model. Chemotherapy 2004; 50: 162-170.
25- Sayed-Ahmed M.M., Mansour H.H., Gharib O.A. and Hafez F.H:
Acetyl-L carnitine Modulates bleomycin-induced oxidative stress and energy
depletion in lung tissues. J Egyptian Nat Cancer Inst 2004; 16: 237-243.
26- El-Demerdash E., Awad A.S, Taha R.M, El-Hady A.M., and Sayed-Ahmed
M.M. Probucol attenuates oxidative stress and energy decline in
isoproterenol-induced congestive heart failure in rat.
Pharmacol Res 2005; 51: 311-318.
27- Sayed-Ahmed M.M and Mohamed A. M.: Contribution of nitric oxide and
epidermal growth factor receptor in antimetastatic potenial of paclitaxel in human
liver cancer cells (Heb G2). J Egyptian Nat Cancer Inst 2005; 17: 35-41.
28- Al-Majed A.A., Sayed-Ahmed M.M., Al-Yahya A.A., Aleisa A.M., Al-Rejaie S.S.
Al-Shabanah O.A. Propionyl-L-carnitine prevents the progression of cisplatin-
induced cardiomyopathy in a carnitine-depleted rat model.
Pharmacol Res 2006; 53: 278-286.
29- Al-Majed A.A., Sayed-Ahmed M.M., Al-Omar F.A., Al-Yahya A.A., Aleisa A.M.
and Al-Shabanah O.A.: Carnitine esters prevent oxidative stress damage and energy
depletion following transient forebrain ischemia in the rat hippocampus. Clin Exp
Pharmacol Physiol 2006; 33: 725-733.
30- Sayed-Ahmed M.M. and Nagi M.N. Thymoquinone supplementation prevents the
development of gentamicin-induced acute renal toxicity in rats. Clin Exp
Pharmacol Physiol 2007; 34: 399-405.
31- Kamel M.W., Salama S.A., Saleh S., Osman A.M., Sayed-Ahmed M.M.,
Al-Hendy A. Reversal of doxorubicin resistance by adenovirus-mediated transfer of
cyclooxygenase-2 antisense in multidrug-resistant MCF-7 cells. Cancer Therapy
2007; 5: 1-10.
32- Sayed-Ahmed MM: Increased Serum and Cardiac Acyl-carnitine/Free Carnitine
ratio During Development of Doxorubicin-Induced Cardiotoxicity.
Saudi Pharmaceutical Journal 2007: 15: 120-126.
33- Sayed-Ahmed MM: Multidrug resistance to cancer chemotherapy: Genes involved
and blockers. Saudi Pharmaceutical Journal 2007: 15: 161-175.