College of Nursing
King Saud University
Course of Advanced Biostatistics (Health 221)
The Instructor:
Dr. Hanan M. Aly, the head of the department of statistics for girls, Faculty of Science, King Saud University.
Email: h_m_hasan@hotmail.com
hmelmat@ksu.edu.sa
Course Description:
(Health 221) is an introductory level statistics course focus on the intuitive understanding of statistical concepts used in biostatistics. The student will be able to organize, summarize and analyze data numerically and using the statistical package (SPSS).
Evaluation:
The class participation and the homework done during the lectures will be considered. There will be two interms exams, each of them will cover a predetermined material. Real data are given to the student and she will be asked to make organization, summarization and analysis using SPSS in the computer lab. Final exam will include all topics covered in the lectures and also some results obtained from analyzing certain data using SPSS to comment on them. The distribution of points one can earn toward a final grade will be as follows:
The Work 
Points 
Quiz 1 
5 
Quiz 2 
5 
Interm exam 1 
12 
Interm exam 2 
13 
Computer Lab 
15 
Final Exam 
50 
Textbook: Daniel, W. (1999): A Foundation for Analysis in the Health Science, 7^{th} Edition, John Wiley & Sons Inc.
The Lectures Schedule
Estimated 
Topic 

Lecture Material 
Reading 
Time 
No. 
Title 


2^{nd} week
3 hours

1 
Introduction to Biostatistics 
1 Some Basic Concepts.
2 Measurement and Measurement Scales.
3 The simple Random Sample. 
Ch. 1
Sec 1.1  1.4 
3^{rd} week
2 hours

2 
Descriptive Statistics 
1 The Frequency Distributions.
2 Measurements of Central Tendency.
3 Measurements of Dispersion. 
Ch. 2
Sec 2.1 – 2.5 
4^{th} week
2 hour

3 
Probability
Concepts 
1 Objective and Subjective Probability.
2 Properties of Probability.
3 The Probability of an Event. 
Ch. 3
Sec 3.1 – 3.4 
5^{th} week
2 hours 
4 
Probability Distributions 
1 The Normal Distribution.
2 Normal Distribution Applications. 
Ch. 4
Sec 4.6 – 4.7 
6^{th} week
1 hour 
InTerm Exam 1. 
Topics: 1, 2, 3 and 4. 
All listed above sections 
6^{th} week
1 hour &
7^{th} week
2 hours &
8^{th} week
1 hour 
5 
Estimation 
1 C.I. for a Population Mean.
2 The t Distribution.
3 C.I. for the Difference between Two Population Means.
4 C.I. for a Population Proportion.
5 C.I. for the Difference between Two Population Proportions. 
Ch. 6
Sec 6.1 – 6.6

8^{th} week
1 hour &
9^{th} week
2 hours &
10^{th} week
2 hours 
6 
Hypothesis Testing 
1 H.T. of a single Population Mean.
2 H.T. of the Difference between Two Population Means.
3 H.T. of a single Population Proportion.
4 H.T. of the Difference between Two Population Proportions.
5 Type I and II errors and the power of a test. 
Ch. 7
Sec 7.1 – 7.6 & 7.9

11^{th} week
2 hours 
InTerm Exam 2.

Topics: 5 and 6. 
All listed above sections 
12^{th} week
2 hours 
7 
ANOVA 
1 Completely Randomized Design.
2 Randomized Complete Block Design. 
Ch. 8
Sec 8.1 – 8.2

13^{th} week
2 hours 
8 
Correlation 
1 The Correlation Model.
2 The Correlation Coefficient. 
Ch. 9
Sec 9.6 – 9.7 
14^{th} week
2 hours 
9 
Regression 
1 The Regression Model.
2 Sample Regression Equation.
3 Using the Regression Equation. 
Ch. 9
Sec 9.1 – 9.4 
According to the schedule
3 hours 
Final Exam. 
Topics: 1 to 9. 
All listed above sections 






The Lab Schedule
Estimated 
Topic 
Lecture Material 
Time 
No. 
Title 

3^{rd} week
1 hour 
1 
Introduction to SPSS 
1 Starting SPSS for Windows.
2 Dealing with Files. 
4^{th} week
1 hour 
2 
Creating Data Files 
1 Naming the Variables.
2 Labeling the Variables.
3 Scaling the Variables. 
5^{th} week
1 hour 
3 
Frequency Tables 
1 Frequency Tables.
2 Representing Data Graphically. 
6^{th} week
1 hour 
4 
Descriptive Statistics 
1 Measurements of Central Tendency.
2 Measurements of Dispersion. 
7^{th} week
1 hour 
5 
Explore Distributions 
1 Explore Statistics.
2 Graphical Displays. 
8^{th} week
1 hour 
6 
T.H. of Single Mean 
1 Calculating T test.
2 Finding C.I. 
9^{th} week
1 hour 
7 
T.H. of 2 Related Means 
1 Calculating Independent Samples T test.
2 Finding C.I. 
10^{th} week
1 hour 
8 
T.H. of 2 Indep. Means 
1 Calculating Independent Samples T test.
2 Finding C.I.

11^{th} week
1 hour 
9 
Oneway ANOVA 
1 Testing the Null Hypothesis.
2 Finding C.I. 
12^{th} week
1 hour 
11 
Correlation 
1 Calculating Pearson Corr. Coeff.
2 Finding C.I. 
13^{th} week
1 hour 
12 
Regression 
1 Linear Regression. 
14^{th} week
1 hours 
Training 
Topics: 1 to 12. 
15^{th} week
3 hours 
Lab Project 
Topics: 1 to 12. 
Homework
The homework will be solved from the text book; Daniel, W. (1999): A Foundation for Analysis in the Health Science, 7^{th} Edition, John Wiley & Sons Inc.
The exercises of chapters 8, and 9 will be solved using the statistical package, SPSS.
Chapter 2 Descriptive Statistics:
Exercise Page 48, no. 2.5.3, 2.5.4, 2.5.5, 2.5.6, and 2.5.14.
Exercise Page 50 no. 17, and no. 20.
Chapter 3 Probability Concepts:
Exercise Page 68 no. 3.4.1 (a), (d), no. 3.4.4 (a), (c), (d).
Exercise Page 76 no. 3 (a), (c), (d), no. 4 (a) 1, 2, 4, (b) 1, 2, 4, 7, and
no. 5 (a), (b), (c), (d), (f), (g) and (h).
Chapter 4 Probability Distributions:
Exercise Page 113 no.4.6.1 to 4.6.10.
Exercise Page 119 no.4.7.1, 4.7.3, 4.7.4, and 4.7.6.
Chapter 6 Estimation:
Exercise Page 160 no.6.2.1, 6.2.3, and 6.2.4.
Exercise Page 165 no.6.3.1, and 6.3.2 (a), (b), and (d).
Exercise Page 172 no.6.4.3, 6.4.5 and 6.4.6.
Exercise Page 177 no.6.5.1, and 6.5.2.
Exercise Page 179 no.6.6.1, and 6.6.4.
Chapter 7 Hypothesis Testing:
Exercise Page 225 no.7.2.2, 7.2.5, 7.2.9, and 7.2.11.
Exercise Page 237 no.7.3.4, 7.3.5, 7.3.6, and 7.3.7.
Exercise Page 247 no.7.4.1, and 7.4.3.
Exercise Page 251 no.7.5.2, and 7.5.3.
Exercise Page 254 no.7.6.4.
Chapter 8 Analysis of Variance:
Exercise Page 318, no.8.2.1, and 8.2.3.
Exercise Page 331, no.8.3.1, and 8.3.5.
Chapter 9 Simple Linear Regression and Correlation:
Exercise Page 440, no.9.7.4, and 9.7.6.
Exercise Page 410, no.9.3.2, and 9.3.6.