PHCL 511 THERAPEUTIC DRUG MONITORING I (0 + 3)
A: Course Description
This course is designed to provide the student with experience in applying both theory and practical principles of clinical pharmacokinetics in patient care setting.
The course consists of short introductory session, monitoring patients and discussions in the ward areas.
B: Course Objectives
Upon successful completion of this course, student shall be able to:
1. Conduct pharmacokinetic and pharmacodynamic assessment of patients receiving drugs that have a narrow therapeutic index or marked variability in their disposition.
2. Define monitoring parameters to include drug concentrations as well as therapeutic endpoints for safe and efficacious use of each drug administer to patients.
3. Devise an initial dosage regimen and monitoring strategy using pharmacokinetic principles and methods for drugs with a narrow therapeutic range or marked variability in their disposition.
4. Assess and monitor the clinical pharmacokinetic parameters of drugs with a narrow therapeutic range or marked variability in their disposition; evaluate patient-specific pharmacokinetic parameter(s) and recommend modifications in drug therapy based upon the changes in the patients condition that alter drug pharmacokinetics.
5. Integrate pharmacokinetics and pharmacodynamics with the pathophysiology of a patients disease.
6. Monitor patients for adverse drug reactions and toxic responses using pharmacokinetic principles and measured drug concentrations.
7. Demonstrate competency in devising individualized dosage regimens using pharmacokinetic models and various support systems (e.g. hand-held calculators androcomputers.
8. Recommend appropriate blood sampling times and analytical methodologies for individualizing patient drug therapy.