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تحميل الدليل التدريبي

أسئلة شائعة


 

Name: Nikhat Jamal Siddiqi

Nationality: Indian

Address:                     

Department of Biochemistry,

King Saud University, PO Box 22452,

Riyadh-11495, Saudi Arabia

Phone: 00966-1-4771548;  Extension - 1393

Email: nikhat@ksu.edu.sa

 Education;

Ph. D. (Biochemistry):   Dr. R. M. L. Avadh University, Faizabad, India.          

Thesis entitled “Studies on oxidative stress/antioxidant defence systems and interferons during malaria infection.”

Supervisor: Prof. Bechan Sharma

M. Sc. (Biochemistry):   University of Madras, Chennai, India.

B. Sc: University of Madras, Chennai, India.

 

Present position: Professor, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.

Membership of Scientific Societies

Member, British Society for matrix Biology

 Life member, Indian society for parasitology.

Member, Indian Society of Biological Chemists

Member, Saudi Chemical Society

Member, Saudi Biological Society

Scholarship and Awards

Senior Research Fellowship (National Institute of Health, Bethesda, Maryland, USA) Sept. 1994-Sept. 1997 at CDRI, Lucknow, India.

Junior Research Fellowship (National Institute of Health, Bethesda, Maryland, USA) Sept. 1992-Sept. 1994 at CDRI, Lucknow, India.

 Current Research Interest;

Biochemistry of hydroxyproline and collagen in various tissues of animals from different species, heavy metal toxicity, sodium fluoride toxicity, atherosclerosis and its effect on aortic collagen.

Research Experience

Maintenance of malarial parasite (Plasmodium yoelii nigeriensis) in vivo in rodents.

Basic techniques of biochemistry viz., enzymology, electrophoresis, protein purification, etc.

Molecular Biology techniques like isolation of RNA, PCR, RTPCR etc.

Knowledge of biochemistry of malaria parasite, parasite enzymes and metabolic pathways as possible drug targets, role of oxidative stress in causing pathology, biochemistry of collagen and hydroxyproline.

Papers

 

 

  1. El-Ansary A,  Shaker G, Siddiqi NJ,  Al-Ayadhi LY Possible ameliorative effects of antioxidants on propionic acid / clindamycin – induced  neurotoxicity in Syrian hamsters.  Gut Pathogens,  2013, 5:32.
  2. Loke SY, Siddiqi NJ, Alhomida AS, Kim HC, Ong WY.  Expression and localization of duodenal cytochrome b in the rat hippocampus after kainate-induced excitotoxicity.  Neuroscience, 2013 15;245:179-90.
  3. Sharma RK, Upadhyay G, Siddiqi NJ, Sharma B.  Pesticides-induced biochemical alterations in occupational North Indian suburban population. Human and Experimental Toxicology, 2013, 1–15.
  4.   Sharma RK, Jaiswal SK, Siddiqi NJ, Sharma B. Effect of carbofuran on some biochemical indices of human erythrocytes in vitro.  Cell Mol Biol (Noisy-le-grand). 2012, 2;58(1):103-9.
  5. Sharma RK, Siddiqi NJ, Sharma B.  Protective effect of silymarin on human erythrocytes against tertbutyl hydroperoxide induced oxidative stress in vitro. American Journal of Biochemistry and Molecular Biology 2012.
  6. Al-Omireeni EA, Siddiqi NJ, Alhomida AS.  Effect of different doses of sodium fluoride on various hydroxyproline fractions in rat kidneys.  Kidney Research Journal 2009; 1-7. ISSN 1819 - 3374 (USA). http://scialert.net/qredirect.php doi=krj.0000.13409.13409&linkid=pdf
  7.  Al-Madani WA, Siddiqi NJ, Alhomida AS.  Renal Toxicity of Mercuric Chloride at Different Time Intervals in Rats.  Biochemistry Insights 2009:2, 37-45.  (New Zealand).  http://www.la-press.com/article.php?article_id=1514
  8. AL-Omairini EA, Al-Afaleg NO, Siddiqi NJ.  Use of Collagen breakdown products in the diagnosis of some connective tissue diseases.  J of King Saud University 2009; 21, 67-73.
  9. Siddiqi NJ, Alhomida AS.  A study on hydroxyproline concentration in humsn erythrocytes. Saudi Journal of Biological Sciences 2008; 12 (2): 149-154.(Saudi Arabia) 
  10. Siddiqi NJ, Abdelhalim MAK,Alhomida AS, Al-Ayed MS. Effect of high cholesterol diet on aortic hydroxyproline and collagen content in rabbits.  Accepted for publication in Research & Reviews in BioSciences 2008.
  11. Siddiqi NJ, Alhomida AS.  Determination of indoleamine 2, 3-dioxygenase activity in tissues of Arabian Camel (Camelus dromedarius).  Arabian Journal of Chemistry 2008: 1(2), 2-13. (Saudi Arabia)
  12. Abdelhalim MAK, Siddiqi NJ, Alhomida AS, Al-Ayed MS.  Effects of feeding periods of high cholesterol and saturated fat diet on blood biochemistry and hydroxyprline fractions in rabbits.  Bioinformatics and Biology Insights 2008: 2, 239 - 244. (New Zealand)
  13. Siddiqi NJ. Free, peptide bond, protein bond, total hydroxyproline and total collagen in rat tissues.  Egyptian Pharmaceutical Journal 2007; 6 (1), 77-85.(Egypt)
  14. Siddiqi NJ, Alhomida AS.  Changes in various htdroxyproline fractions in rat kidneys after mercuric chloride treatment.  International journal of Biological Chemistry 2007; 1 (2), 84 – 90. (Australia)
  15. Siddiqi NJ, Alhomida AS.  Effect of mercuric chloride on urinary excretion of free hydroxyproline.  Medical Science Monitor 2006; 12 (3), 95-101. (USA)
  16. Siddiqi NJ, Alhomida AS.  Effect of mercuric chloride on various hydroxyproline fractions in rat serum.  Molecular and Cellular Biochemistry 2005; 271, 159-165.(Netherland)
  17. Siddiqi NJ, Alhomida AS.  Hydroxyproline concentrations in ocular tissues of Arabian camel ( Camelus dromedaries Linn. ).  Indian Journal of Biochemistry & Biophysics 2003; 40, 451-454. (India)
  18. Siddiqi NJ, Alhomida AS.  Investigation into the Distribution of Total, Free, Peptide-bound, Protein-bound, Soluble- and Insoluble-Collagen Hydroxyproline in Various Bovine Tissues. Journal of Biochemistry and Molecular Biology 2003; 36, 154 - 158. (South Korea) 
  19. Siddiqi NJ, Alhomida AS, Pandey VC.  Hydroxyproline distribution in the Plasma of Different Mammals.  Journal of Biochemistry, Molecular Biology and Biophysics 2002; 6 (2), 159-162. (USA)
  20. Siddiqi NJ.   A Comparitive Study on the distribution of Hydroxyproline in the tissues of two desert animals viz., Arabian Camel (Camelus dromedarius) and Arabian Sand Gazelles (Gazella subgutturosa marica).  Journal of Saudi Chemical Society 2002; 6, 21-26.(Saudi Arabia)
  21. Srivastava S, Alhomida AS, Siddiqi NJ, Puri SK, Pandey VC.  Methemoglobin reductase activity and in vitro sensitivity towards oxidant induced methemoglobinemia in Swiss mice and Beagle dogs erythrocytes.  Molecular and Cellular Biochemistry  2002; 232: 81-85. (UK)
  22. Siddiqi NJ, Alhomida AS.  Distribution of total, free, peptide-bound and protein bound hydroxyproline in the erythrocytes from different species.  Comparitive Clinical Pathology.  2002; 11: 123-128.(USA)
  23. Siddiqi NJ, Alhomida AS, Dutta GP,  Pandey VC.  Antagonist effect of Chloroquine and Tumor Necrosis Factor on Hepatic Oxidative Stress and Antioxidant Defense in normal and Plasmodium yoelii nigeriensis infected mice.  In Vivo.  2002; 16: 67- 70. (Greece)
  24. Srivastava S, Alhomida AS, Siddiqi NJ, Pandey VC.  Changes in rodent-erythrocyte Methemoglobin reductase system produced by two malaria parasites, viz. Plasmodium yoelii nigeriensis and Plasmodium berghei.  Comparative Biochemistry and Physiology Part B 2001; 129: 725-731(UK)
  25. Srivastava S, Alhomida AS, Siddiqi NJ, Pandey VC, Puri SK.  Effect of beta-arteether treatment on erythrocytic methemoglobin reductase in Plasmodium yoelii nigeriensis infected mice.  Drug and Chemical Toxicology. 2001; 24 (2): 181-190. (USA)
  26. Siddiqi NJ, Alhomida AS, Maheshwari RK, Pandey VC.  Effect of poly ICLC treatment on hepatic oxidative stress and antioxidant defense indices in Plasmodium yoelii nigeriensis infected mice.  In Vivo. 2001; 15 (1): 77-80.(Greece)
  27. Siddiqi NJ, Alhomida AS.  A study of the distribution of total, free, peptide-bound and protein-bound hydroxyproline in the plasma of Arabian camel (Camelus dromadarius).  Comparitive Haematology International. 2000; 10: 144-147. (UK)
  28. Siddiqi NJ, Sharma B, Alhomida AS.  A study on distribution of different hydroxyproline fractions in bovine ocular tissues.  Molecular and Cellular Biochemistry  2001; 217 (1-2): 67-71. (Netherland) 
  29. Siddiqi NJ, Al-Jafari AA, Alhomida AS.  Investigation of total, free, peptide-bound, protein-bound, soluble and insoluble collagen hydroxyproline content in tissues from the Arabian camel (Camelus dromadarius).  Cell Biochemistry Function  2000; 18 (4): 243-248. (Canada)
  30. Siddiqi NJ.  Determination of total, free, peptide-bound, protein-bound, soluble and insoluble collagen hydroxyproline content in tissues from Arabian sand gazella (Gazella subgutturosa marica).  Saudi Journal of Biological Sciences 2000; 7 (1): 104-112.(Saudi Arabia) 
  31. Siddiqi NJ, Alhomida AS, Sharma B, Pandey VC.  Effect of tumor necrosis factor on hepatic oxidative stress and antioxidant defense indices in normal and Plasmodium yoelii nigeriensis infected mice.  Drug and Chemical Toxicology 2000; 23 (4): 671-678. (USA)
  32. Srivastava S, Alhomida AS, Siddiqi NJ.  Studies on erythrocytic methemoglobin reductase systems in  Plasmodium yoelii nigeriensis infected mice.  In Vivo.  2000; 14 (4): 547-550. (Greece)
  33. AL-Madani HA, Al-Jafari AA, Alhomida AS, Siddiqi NJ, Sobki SH, AL-Khader AA.  A comparative study of carnitine removal rate during haemodialysis with two different membranes.  Medical Science Research 2000; 28: 23-27. (UK)
  34. Siddiqi NJ, Alhomida AS.  Status of hepatic oxidative stress and antioxidant defense systems during chloroquine treatment of Plasmodium yoelii nigeriensis infected mice.  In Vivo. 1999; 13 (6): 547-550.(Greece)
  35. Al-Madani HA, AL-Jafari AA, Alhomida AS, Siddiqi NJ, Sobki SH, Al-Khader AA, Popovich WF.  Impact of haemodialysis membranes on human serum total, free, short-chain acyl and long-chain acyl carnitine concentrations.  Medical Science Research 1999; 27: 485-488. (UK)
  36. Siddiqi NJ, Pandey VC.  Studies on hepatic oxidative stress and antioxidant defence systems during arteether treatment of Plasmodium yoelii nigeriensis infected mice.  Molecular and Cellular Biochemistry 1999; 196: 169-173. (Netherland)
  37. Siddiqi NJ, Puri SK, Dutta GP. Maheshwari RK, Pandey VC.  Studies on hepatic oxidative stress and antioxidant defence system during chloroquine/poly ICLC treatment of Plasmodium yoelii nigeriensis infected mice.  Molecular and Cellular Biochemistry 1999; 194: 179-183.(Netherland)
  38. Siddiqi NJ, Saxena JK, Tripathi LM, Dutta GP, Pandey VC.  Partial purification and characterization of hepatic xanthine oxidase of Plasmodium yoelii nigeriensis infected mice.  J Parasitic Dis. 1996; 20 (2): 155-158. (India) 

Conferences

 

 

2nd International Summit on Toxicology (7-9th October, 2013 Las Vegas, USA).  Studies on the neurochemical effects of propionic acid and clindamycin- induced bacterial overgrowth alone and in combination with antioxidants in hamsters.

 

7th International Conference on Proteoglycans, (16th – 20 October 2011, Sydney, Australia)

N. J.  Siddiqi*. Studies on effects the of sodium fluoride on collagen content in various rat tissues.

 

XII nd Meeting of Federation of European Connective Tissue Societies, Davos, Switzerland (3-7 July, 2010) Siddiqi NJ. Effect of sodium fluoride and magnesium chloride on collagen content of rat kidneys.

 

National Conference on Emerging Trends in Biochemistry and Satellite Symposia of the Academy of Environmental Biology, Allahabad, India (23 -24 January, 2010) Siddiqi NJ.  Effect of sodium fluoride on rat lung collagen.

 Nanostructured Advanced Materials, University of Jordan, Amman, Jordan (10 – 13th  November, 2008) Siddiqi NJ.  Nanoparticles and Collagen.

Brain Function and Repair, National University of Singapore, Singapore, 1st – 5th September, 2008.

Siddiqi NJ.  Biomedical Uses of Collagen.Third Saudi Science Conference (New Horizons in Science and their Applications), King Saud University, Riyadh, Saudi Arabia (10 – 13th March, 2007)

Al-Omairini EA, Al-Afaleg NO, Siddiqi NJ.  Use of collagen breakdown products in the diagnosis of various diseases. Third Saudi Science Conference (New Horizons in Science and their Applications), King Saud University, Riyadh, Saudi Arabia (10 – 13th March, 2007)

 The 9th international pharmaceutical sciences conference & exposition, King Saud University, Riyadh, Saudi Arabia (17 – 21 December, 2005):Siddiqi NJ, Alhomida AS.  Effect of mercuric chloride and 2, 3-dimercaprto-1-propanesulfonic acid treatment on free hydroxyproline levels in rats.

The international conference on date palm, King Saud University  Al - Qaseem Branch, AL-Qaseem, Saudi Arabia (6 - 9 April, 2003):Twaijri IM, Siddiqi NJ, Alhomida AS.  Determination of ascorbic acid concentrations in various species of local palm cultivars.

International conference on role of free radicals and anti-oxidants in health and disease & II nd Annual Conference of SFRR - India, Lucknow, India ( February 10 - 12, 2003):Siddiqi NJ, Alhomida AS.  Hepatic hydroxyproline as a marker for free radical damage and free radical induced fibrosis

Experimental Biology 2002; Translating the gene, New Orleans, Lousiana, USA (April 20-24, 2002):Siddiqi NJ, Alhomida AS. Distribution of the distribution of total, free, peptide-bound and protein-bound hydroxyproline in the plasma of different mammals.

Symposium on the effect of modern science and technology on human life, King Saud University, Riyadh, Saudi Arabia (March 2002):Siddiqi NJ.  Genetically modified foods.

Second international conference of comparative physiology and biochemistry in Africa: how animals work, Botswana, South Africa (August 18-24, 2001):Siddiqi NJ, Alhomida AS, Pandey VC.  A comparative study of the distribution of total, free, protein-bound and peptide-bound hydroxyproline in the plasma of different mammals.

18th International congress of biochemistry and molecular biology: Beyond the gene.  Birmingham, UK (July 16-20, 2000):Alhomida AS, Siddiqi NJ.  Investigations of total, free, peptide-bound, protein-bound,  soluble and insoluble collagen hydroxyproline content in ocular tissues of the bovine.

Biological Chemistry, Beyond 2000 AD, Dr. R. M. L. Avadh University, Faizabad, India (Nov 27-28, 1999):  Siddiqi NJ, Al-Jafari AA, Alhomida AS.  Investigation of total, free, peptide-bound, protein-bound, soluble and insoluble collagen hydroxyproline content in tissues frm the Arabian camel (Camelus dromadarius).

 International conference on oxidative stress in skin biology and medicine. Attiki, Greece (September 13-16, 1999):  Siddiqi NJ, Alhomida  AS.  Comparative effects of chloroquine and tumor necrosis factor treatment on hepatic oxidative stress and antioxidant defense indices in Plasmodium yoelli nigeriensis infected mice.

 Second Global Meet on Parasitic Diseases with Focus on Malaria, Hyderabad, India (August 18-22 , 1997):  Nikhat J. Siddiqi, S. K. Puri, R. K. Maheshwari, G. P. Dutta and V. C. Pandey. Synergistic effect of Arteether and poly ICLC treatment on hepatic oxidative stress and antioxidant defence indices during Plasmodium yoelii nigeriensis infection in mice.

 65th Annual Meeting of the Society of Biological Chemists, Bangalore, India ( November 20-23, 1996): Nikhat J. Siddiqi.  Effect of inhibitors of hepatic xanthine oxidase from normal and Plasmodium yoelii nigeriensis infected mice.

 Global Meet on Parasitic Diseases, New Delhi,India (March 18-22, 1996):Nikhat J. Siddiqi, J. K. Saxena, L. M. Tripathi, G. P. Dutta and V. C. Pandey. Characterization of hepatic xanthine oxidase of normal and Plasmodium yoelii nigeriensis infected mice.

 XII National Congress of Parasitology, Goa, India (January 23-25, 1995):Nikhat J. Siddiqi, J. K. Saxena, L. M. Tripathi,  G. P. Dutta and V. C. Pandey.  Effect of tumor necrosis factor (TNF) on hepatic oxidative stress and antioxidant defence indices during Plasmodium yoelii nigeriensis infection in mice.

 XI National Congress of Parasitology, Udaipur, India (February 22-24, 1994):Nikhat J. Siddiqi, Pratima Srivastava, J. K. Saxena, G. P. Dutta and V. C. Pandey. Hepatic Biochemical changes due to Plasmodium yoelii nigeriensis infection in mice.

 

 Other Scientific activities:

Reviewer of manuscripts for many international and national scientific journals.

 Past supervisor to MSc student Eman Al-Omeraini for her project entitled "The effect of sodium fluoride administration on hydroxyproline concentration in  rat kidneys".

Examiner

Examiner for the MSc thesis entitled "Hemostatic and fibrinolytic profile in type 2 diabetes mellitus: effect on the incidence and severity of diabetic Complications" by Ms Samha Mohamed Zohair Al-Ayoubi for the defence held on 17/1/2010.

Examiner for the MSc thesis entitled "Oxidative stress and antioxidant status in Saudi asthamatic patients" by Ms Nouf Al-Afaleg for the defence held on 3/1/2010.

Training

1.One month (7/8/2008 to 5/9/2008) training in "Studies on the Effect of Nanoparticles in Biological System" at National University of Singapore, Centre for Life Sciences (CeLS) in the research group headed by Associate Professor Wei-Yi ONG.

2. One week training at National Chemical Laboratory, Pune, India on preparation of Nanoparticles by chemical and hydrothermal methods.

This page was last updated on 6/2/2014

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