BCH 442, Molecular Biology – I
Credit hours – 2
Prerequisite – BCH 221
Syllabus for BCH 442, Molecular Biology
The discovery of nucleic acid and their relation to genetic information. The chemical constituents of nucleic acids.
Lecture 2 – 4:
The biosynthesis and degradation of purine and pyrimidine nucleotides and their metabolic disorders.
Lecture 5 – 6:
The cell cycle and cell divisions (mitosis and meiosis).
The structure of DNA, Watson & Crick double helix model, types of double helices, linear & circular DNA, physical properties of DNA double helix.
First Continuous Assessment
Lecture 8 – 9:
DNA replication, the enzymes and proteins of replication, role of template, the Okazaki fragments, mechanism of replication and the effect of antibiotics on it.
Lecture 10 – 11:
Transcription of DNA, various types of RNA, mechanism of transcription and enzymes involved, control of transcription.
The structure of tRNA and the ribosome.
Lecture 13 – 14:
The genetic code and its characteristics, wobble hypothesis.
Second Continuous Assessment
Lecture 15 – 16:
Gene expression. The enzymes, proteins, mechanism and control of translation. The effect of antibiotics on translation.
Lecture 17 – 18:
Regulation of gene expression and operon model.
Lecture 19 – 20:
Mutation of the gene, types, repair system and the effect of mutagens.
Lecture 21 – 22:
Post transcriptional and post-translational processes and their control.
Lecture 23 – 24:
Eukaryotic DNA, structure, role of histones etc.
1. Lippincot's Illustrated Reviews Biochemistry
2. Lechninger's Principles of Biochemistry 4th edition. D. L. Nelson and M.M. Cox, Worth Publishers.
3. Biochemistry & Molecular Biology by W. H. Elliot and D. C. Elliot.