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تحميل الدليل التدريبي

أسئلة شائعة


  Publications

  1. M.M.Sayed-Ahmed and M.N.Nagi, Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats, Clin. Exp. Pharmacol. Physiol 34 (2007) 399.                          

  2. M.M.Khattab and M.N.Nagi, Thymoquinone supplementation attenuates hypertension and renal damage in nitric oxide deficient hypertensive rats, Phytother. Res. 21 (2007) 410.                     

  3. S.T.Al-Rashood, I.A.Aboldahab, M.N.Nagi, L.A.Abouzeid, A.A.bdel-Aziz, S.G.bdel-Hamide, K.M.Youssef, A.M.Al-Obaid, and H.I.El-Subbagh,  Synthesis, dihydrofolate reductase inhibition, antitumor testing, and molecular modeling study of some new 4(3H)-quinazolinone analogs, Bioorg. Med. Chem. 14 (2006) 8608.      

  4. A.A.Al-Majed, F.A.Al-Omar, and M.N.Nagi,  Neuroprotective effects of thymoquinone against transient forebrain ischemia in the rat hippocampus, Eur. J. Pharmacol. 543 (2006) 40.             

  5. F.A.Al-Omar, M.N.Nagi, M.M.Abdulgadir, K.S.Al Joni, and A.A.Al-Majed,  Immediate and delayed treatments with curcumin prevents forebrain ischemia-induced neuronal damage and oxidative insult in the rat hippocampus, Neurochem. Res. 31 (2006) 611.       

  6. M.A.Mansour, A.G.El-Din, M.N.Nagi, O.A.Al-Shabanah, and A.M.Al-Bekairi,  Nomega-nitro-L-arginine methylester ameliorates myocardial toxicity induced by doxorubicin, J. Biochem. Mol. Biol. 36 (2003) 593.          

  7. A.M.Gamal el-din, A.M.Mostafa, O.A.Al-Shabanah, A.M.Al-Bekairi, and M.N.Nagi,  Protective effect of arabic gum against acetaminophen-induced hepatotoxicity in mice, Pharmacol. Res. 48 (2003) 631.     

  8. M.N.Nagi, M.A.Mansour, O.A.Al-Shabanah, and H.A.El-Kashef,  Melatonin inhibits the contractile effect of vanadate in the isolated pulmonary arterial rings of rats: possible role of hydrogen peroxide, J. Biochem. Mol. Toxicol. 16 (2002) 273.  

  9. A.R.bd-Allah, A.A.Al-Majed, A.M.Mostafa, O.A.Al-Shabanah, A.G.Din, and M.N.Nagi,  Protective effect of arabic gum against cardiotoxicity induced by doxorubicin in mice: a possible mechanism of protection, J. Biochem. Mol. Toxicol. 16 (2002) 254.    

10. M.A.Mansour, A.M.Mostafa, M.N.Nagi, M.M.Khattab, and O.A.Al-Shabanah,  Protective effect of aminoguanidine against nephrotoxicity induced by cisplatin in normal rats, Comp Biochem. Physiol C. Toxicol. Pharmacol. 132 (2002) 123. 

11. M.A.Mansour, M.N.Nagi, A.S.El-Khatib, and A.M.Al-Bekairi,  Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action, Cell Biochem. Funct. 20 (2002) 143.             

12. K.Alam, M.N.Nagi, O.A.Al-Shabanah, and A.M.Al-Bekairi,  Beneficial effect of nitric oxide synthase inhibitor on hepatotoxicity induced by allyl alcohol, J. Biochem. Mol. Toxicol. 15 (2001) 317.          

13. A.M.Mostafa, M.N.Nagi, A.C.Al Rikabi, O.A.Al-Shabanah, and H.A.El-Kashef,  Protective effect of aminoguanidine against cardiovascular toxicity of chronic doxorubicin treatment in rats, Res. Commun. Mol. Pathol. Pharmacol. 106 (1999) 193.     

14. M.N.Nagi and M.A.Mansour,  Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: a possible mechanism of protection, Pharmacol. Res. 41 (2000) 283.       

15. O.A.Al-Shabanah, K.Alam, M.N.Nagi, A.C.Al-Rikabi, and A.M.Al-Bekairi,  Protective effect of aminoguanidine, a nitric oxide synthase inhibitor, against carbon tetrachloride induced hepatotoxicity in mice, Life Sci. 66 (2000) 265. 

16. O.A.Badary, O.A.Al-Shabanah, M.N.Nagi, A.C.Al-Rikabi, and M.M.Elmazar,  Inhibition of benzo(a)pyrene-induced forestomach carcinogenesis in mice by thymoquinone, Eur. J. Cancer Prev. 8 (1999) 435

17. K.Alam, M.N.Nagi, O.A.Badary, O.A.Al-Shabanah, A.C.Al-Rikabi, and A.M.Al-Bekairi,  The protective action of thymol against carbon tetrachloride hepatotoxicity in mice, Pharmacol. Res. 40 (1999) 159.         

8. M.N.Nagi, K.Alam, O.A.Badary, O.A.Al-Shabanah, H.A.al-Sawaf, and A.M.Al-Bekairi,  Thymoquinone protects against carbon tetrachloride hepatotoxicity in mice via an antioxidant mechanism, Biochem. Mol. Biol. Int. 47 (1999) 153.    

19. O.A.Al-Shabanah, O.A.Badary, M.N.Nagi, N.M.al-Gharably, A.C.Al-Rikabi, and A.M.Al-Bekairi,  Thymoquinone protects against doxorubicin-induced cardiotoxicity without compromising its antitumor activity, J. Exp. Clin. Cancer Res. 17 (1998) 193.     

20. O.A.Badary, M.N.Nagi, O.A.Al-Shabanah, H.A.al-Sawaf, M.O.al-Sohaibani, and A.M.Al-Bekairi,  Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity, Can. J. Physiol Pharmacol. 75 (1997) 1356.      

21. O.A.Badary, M.N.Nagi, H.A.al-Sawaf, M.Al-Harbi, and A.M.Al-Bekairi,  Effect of L-histidinol on cisplatin nephrotoxicity in the rat, Nephron 77 (1997) 435.   PubMed  

22. M.N.Nagi, A.M.Al-Bekairi, and H.A.al-Sawaf,  Spectrophotometric assay for superoxide dismutase based on the nitroblue tetrazolium reduction by glucose-glucose oxidase, Biochem. Mol. Biol. Int. 36 (1995) 633.       

23. A.M.Al-Bekairi, M.N.Nagi, H.A.Shoeb, and H.A.al-Sawaf,  Evidence for superoxide radical production by a simple flavoprotein: glucose oxidase, Biochem. Mol. Biol. Int. 34 (1994) 233.      

24. L.Cook, M.N.Nagi, S.K.Suneja, A.R.Hand, and D.L.Cinti,  Evidence that beta-hydroxyacyl-CoA dehydrase purified from rat liver microsomes is of peroxisomal origin, Biochem. J. 287 ( Pt 1) (1992) 91.    

25. M.N.Nagi, S.K.Suneja, L.Cook, and D.L.Cinti,  Depletion of rat hepatic glutathione and inhibition of microsomal trans-2-enoyl-CoA reductase activity following administration of a dec-2-ynol and dec-2-ynoic acid, Arch. Biochem. Biophys. 293 (1992) 71.     

26. D.L.Cinti, L.Cook, M.N.Nagi, and S.K.Suneja,  The fatty acid chain elongation system of mammalian endoplasmic reticulum, Prog. Lipid Res. 31 (1992) 1.      

27. S.K.Suneja, M.N.Nagi, L.Cook, and D.L.Cinti,  Decreased long-chain fatty acyl CoA elongation activity in quaking and jimpy mouse brain: deficiency in one enzyme or multiple enzyme activities?, J. Neurochem. 57 (1991) 140.    

28. S.K.Suneja, M.N.Nagi, L.Cook, P.Osei, and D.L.Cinti,  Do rat kidney cortex microsomes possess the enzymatic machinery to desaturate and chain elongate fatty acyl-CoA derivatives?, Lipids 26 (1991) 359.   

29. S.K.Suneja, P.Osei, L.Cook, M.N.Nagi, and D.L.Cinti,  Enzyme site-specific changes in hepatic microsomal fatty acid chain elongation in streptozotocin-induced diabetic rats, Biochim. Biophys. Acta 1042 (1990) 81.   

30. M.N.Nagi, L.Cook, S.K.Suneja, P.S.Peluso, J.C.Laguna, P.Osei, and D.L.Cinti,  Evidence for two separate beta-ketoacyl CoA reductase components of the hepatic microsomal fatty acid chain elongation system in the rat, Biochem. Biophys. Res. Commun. 165 (1989) 1428.     

31. M.N.Nagi, L.Cook, S.K.Suneja, P.S.Peluso, J.C.Laguna, P.Osei, and D.L.Cinti,  Evidence for two separate beta-ketoacyl CoA reductase components of the hepatic microsomal fatty acid chain elongation system in the rat, Biochem. Biophys. Res. Commun. 164 (1989) 927.      

32. M.N.Nagi, L.Cook, S.K.Suneja, P.Osei, and D.L.Cinti,  Spectrophotometric assay for the condensing enzyme activity of the microsomal fatty acid chain elongation system, Anal. Biochem. 179 (1989) 251.     

33. P.Osei, S.K.Suneja, J.C.Laguna, M.N.Nagi, L.Cook, M.R.Prasad, and D.L.Cinti,  Topography of rat hepatic microsomal enzymatic components of the fatty acid chain elongation system, J. Biol. Chem. 264 (1989) 6844.

34. M.N.Nagi, J.C.Laguna, L.Cook, and D.L.Cinti,  Disruption of rat hepatic microsomal electron transport chains by the selenium-containing anti-inflammatory agent Ebselen, Arch. Biochem. Biophys. 269 (1989) 264.    

35. J.C.Laguna, M.N.Nagi, L.Cook, and D.L.Cinti,  Action of Ebselen on rat hepatic microsomal enzyme-catalyzed fatty acid chain elongation, desaturation, and drug biotransformation, Arch. Biochem. Biophys. 269 (1989) 272.    

36. M.N.Nagi, L.Cook, J.C.Laguna, and D.L.Cinti,  Dual action of 2-decynoyl coenzyme A: inhibitor of hepatic mitochondrial trans-2-enoyl coenzyme A reductase and peroxisomal bifunctional protein and substrate for the mitochondrial beta-oxidation system, Arch. Biochem. Biophys. 267 (1988) 1.     

37. D.Ghesquier, L.Cook, M.N.Nagi, T.J.MacAlister, and D.L.Cinti,  Source of the hepatic microsomal trans-2-enoyl CoA hydratase bifunctional protein: endoplasmic reticulum or peroxisomes, Arch. Biochem. Biophys. 252 (1987) 369.    

38. L.Cook, D.Ghesquier, M.N.Nagi, L.V.Favreau, and D.L.Cinti,  Biochemical and immunological identity of the hepatic peroxisomal and microsomal trans-2-enoyl CoA hydratase bifunctional protein, Arch. Biochem. Biophys. 252 (1987) 357.  

39. M.N.Nagi, L.Cook, M.R.Prasad, and D.L.Cinti,  Do rat hepatic microsomes contain multiple NADPH-supported fatty acid chain elongation pathways or a single pathway?, Biochem. Biophys. Res. Commun. 140 (1986) 74.      

40. M.N.Nagi, L.Cook, D.Ghesquier, and D.L.Cinti,  Site of inhibition of rat liver microsomal fatty acid chain elongation system by dec-2-ynoyl coenzyme A. Possible mechanism of inhibition, J. Biol. Chem. 261 (1986) 13598.   

41. M.N.Nagi, L.Cook, D.Ghesquier, and D.L.Cinti,  Induction of rat liver mitochondrial fatty acid elongation by the administration of peroxisome proliferator di-(2-ethylhexyl)phthalate: absence of elongation activity in peroxisomes, Arch. Biochem. Biophys. 248 (1986) 408.    

42. M.R.Prasad, M.N.Nagi, D.Ghesquier, L.Cook, and D.L.Cinti,  Evidence for multiple condensing enzymes in rat hepatic microsomes catalyzing the condensation of saturated, monounsaturated, and polyunsaturated acyl coenzyme A, J. Biol. Chem. 261 (1986) 8213.    

43. L.Cook, M.N.Nagi, J.Piscatelli, T.Joseph, M.R.Prasad, D.Ghesquier, and D.L.Cinti,  Hepatic subcellular distribution of short-chain beta-ketoacyl coenzyme A reductase and trans-2-enoyl coenzyme A hydratase: 25- to 50-fold stimulation of microsomal activities by the peroxisome proliferator, di-(2-ethylhexyl)phthalate, Arch. Biochem. Biophys. 245 (1986) 24.  PubMed      

44. M.N.Nagi, M.R.Prasad, L.Cook, and D.L.Cinti,  Biochemical properties of short- and long-chain rat liver microsomal trans-2-enoyl coenzyme A reductase, Arch. Biochem. Biophys. 226 (1983) 50.    

45. M.R.Prasad, M.N.Nagi, L.Cook, and D.L.Cinti,  Kinetic evidence for two separate trans-2-enoyl CoA reductases in rat hepatic microsomes: NADPH-specific short chain- and NAD(P)H-dependent long chain-reductase, Biochem. Biophys. Res. Commun. 113 (1983) 659.   

46. D.L.Cinti, M.N.Nagi, L.Cook, and R.E.White,  Evidence for a second microsomal trans-2-enoyl coenzyme A reductase in rat liver. NADPH-specific short chain reductase, J. Biol. Chem. 257 (1982) 14333.     


 

 
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