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Molecular Genetics

BCH 550 

 (3+0) credit-hours

Time

 Class Room  B:
 

   The course is divided into 9 modules(3 hours each) which in turn are grouped into three sessions. A session will be allocated to certain instructor. Each instructor is asked to discuss with students one review article and a minimum of one research paper during his/her session

   Mark distributions. Each instructor has 100 marks ×3 =300, the final marks of instructors divided by factor (3). The letter grade for the course will be based on the results of one exam (60%). In addition (20%) for one presented research that is now based on research paper (and/or review article), the evaluation process depends on the assigned staff member. The last (20%)evaluation of an original research proposal written by the student in collaboration with the course instructor that is composed of 5-10 pages and includes: Title (suggested by the staff member), Literature Review, Aims(S), Methodology, Expected Outcome and References. Evaluation of this proposal will be totally by the assigned staff member.   

Module

Topics

1

Elements of DNA:

genes, pseudo-genes transposable elements, repetitive DNA, etc. Eukaryotic and prokaryotic  genome; Fundamental features of eukaryotic  and prokaryotic genes.

2

Gene interaction:

from genes to phenotypes, diagnostic test for alleles, interactions between the alleles of one gene.

3

DNA recombination, rearrangements:

Independent Assortment, Crossing-Over, Linkage Maps, Mitotic Crossing-Over, The Mechanism of Crossing-Over , etc

4

DNA replication:

the cell cycle; control and defects, apoptosis, DNA repair: mechanisms, methods to study DNA repair, syndromes.

5

Chromosome mutations:

introduction, changes in chromosome number, chromosomal rearrangements, the overall incidence of human chromosome mutations and evolution of the genome

6

Cytogenetics:

understanding the disease progression process, classical and molecular cytogenetic methods, chromosome segregation, the abnormalities in clinical syndromes and cancer

7

Transcription:

machinery and regulation (activators and repressors, histone modification, methylation). Epigenetic modification of the genome. Control of gene expression.  RNA interference as a mechanism for control of gene expression, splicing and connections with human diseases.

8

Translation:

mechanisms, regulation, post-translational modifications.

9

Bioinformatics

             

 

 Lectures