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442 BCH
(2+0) credit-hours
 

Dr Mohamed AL Anazi- KSU

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Course Description:

This course covers fundamental aspects of molecular biology with emphasis on human genome: composition, chemical and physical properties, genes, and gene products. The course covers most DNA-associated processes such as replication, transcription, translation, as well as DNA transposition, recombination and rearrangements, gene expression, and recent advances in molecular biology. The course aims at providing basic knowledge necessary to understand the importance of the central dogma in molecular biology and the more advanced concepts such as genetic engineering or recombinant DNA technology.

 

Text Book:

1)     Nelson, DL; Cox, ML. Lehninger : Principles of Biochemistry. Worth Publishers; New York. 2004 or later

 

Reference Books: 

1)     Watson, Baker, Gann, Levine, and Losick: Molecular Biology of the gene. Benjamin Cummings; USA. 2003 or later

2)     Tropp, B; Molecular Biology genes to proteins. Jones and Bartlett Publisher. 2008.

 

  

Lectures Table ( 1428-1429):

 Time

Lecture

Date

 

Introduction to molecular biology

10-02-1429

Discovering the chemical nature of the genetic material

12-02-1429

Chemical structure of nucleosides and nucleotides and their nomenclature

17-02-1429

Primary and secondary structure of nucleic acids and different form of DNA conformations

19-02-1429

Tertiary structure of nucleic acids

24-02-1429

DNA melting and annealing

26-02-1429

Nucleotide metabolism I

01-03-1429

Nucleotide metabolism II

03-03-1429

Nucleotide metabolism  Syndrome

08-03-1429

Cell cycle an introduction

10-03-1429

Oncogenes and tumor suppressor genes

15-03-1429

Cell Cycle and Cancer

17-03-1429

DNA replication I

22-03-1429

DNA replication II

24-03-1429

Telomeres and telomerase

29-03-1429

Review

02-04-1429

Exam. ( 1 )

02-04-1429

 No class Spring Break

07-04-1429

No class  Spring Break

09-04-1429

DNA damage and mutagenesis

14-04-1429

DNA Repair I

16-04-1429

DNA Repair II

21-04-1429

DNA Repair syndrome  

23-04-1429

Transcription an introduction

28-04-1429

Transcription in prokaryotes

01-05-1429

Transcription in eukaryotes

06-05-1429

Posttranscriptional modification and transcription syndrome

08-05-1429

Exam. ( 2 )

13-05-1429

Translation an introduction

15-05-1429

Translation  in prokaryotes

20-05-1429

 

Translation in eukaryotes

22-05-1429

Prelude to recombinant and DNA technologies

27-05-1429

 

Review

29-05-1429

 

 

 

 

Months

 

Exam