442 BCH
(2+0) credit-hours
Dr Mohamed AL Anazi- KSU
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Course Description:
This course covers fundamental aspects of molecular biology with emphasis on human genome: composition, chemical and physical properties, genes, and gene products. The course covers most DNA-associated processes such as replication, transcription, translation, as well as DNA transposition, recombination and rearrangements, gene expression, and recent advances in molecular biology. The course aims at providing basic knowledge necessary to understand the importance of the central dogma in molecular biology and the more advanced concepts such as genetic engineering or recombinant DNA technology.
Text Book:
1) Nelson, DL; Cox, ML. Lehninger : Principles of Biochemistry. Worth Publishers; New York. 2004 or later
Reference Books:
1) Watson, Baker, Gann, Levine, and Losick: Molecular Biology of the gene. Benjamin Cummings; USA. 2003 or later
2) Tropp, B; Molecular Biology genes to proteins. Jones and Bartlett Publisher. 2008.
Lectures Table ( 1428-1429):
|
Time |
Lecture |
Date |
|
|
Introduction to molecular biology |
10-02-1429 |
|
Discovering the chemical nature of the genetic material |
12-02-1429 |
|
Chemical structure of nucleosides and nucleotides and their nomenclature |
17-02-1429 |
|
Primary and secondary structure of nucleic acids and different form of DNA conformations |
19-02-1429 |
|
Tertiary structure of nucleic acids |
24-02-1429 |
|
DNA melting and annealing |
26-02-1429 |
|
Nucleotide metabolism I |
01-03-1429 |
|
Nucleotide metabolism II |
03-03-1429 |
|
Nucleotide metabolism Syndrome |
08-03-1429 |
|
Cell cycle an introduction |
10-03-1429 |
|
Oncogenes and tumor suppressor genes |
15-03-1429 |
|
Cell Cycle and Cancer |
17-03-1429 |
|
DNA replication I |
22-03-1429 |
|
DNA replication II |
24-03-1429 |
|
Telomeres and telomerase |
29-03-1429 |
|
Review |
02-04-1429 |
|
Exam. ( 1 ) |
02-04-1429 |
|
No class Spring Break |
07-04-1429 |
|
No class Spring Break |
09-04-1429 |
|
DNA damage and mutagenesis |
14-04-1429 |
|
DNA Repair I |
16-04-1429 |
|
DNA Repair II |
21-04-1429 |
|
DNA Repair syndrome |
23-04-1429 |
|
Transcription an introduction |
28-04-1429 |
|
Transcription in prokaryotes |
01-05-1429 |
|
Transcription in eukaryotes |
06-05-1429 |
|
Posttranscriptional modification and transcription syndrome |
08-05-1429 |
|
Exam. ( 2 ) |
13-05-1429 |
|
Translation an introduction |
15-05-1429 |
|
Translation in prokaryotes |
20-05-1429 |
|
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Translation in eukaryotes |
22-05-1429 |
|
Prelude to recombinant and DNA technologies |
27-05-1429 |
|
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Review |
29-05-1429 |
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Exam |
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