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Student’s Name: _______________________________ Number: _______________

Department of Family and Community Medicine

Mid Term Examination

COMM-421 (Females 1st batch)

Wednesday: 21.3.1427 (19.4.2006)

Time: 10:30 – 11:30


Part C:                                                                                        (4 marks)


Critical Reading Questions (CRQs)


Q1.       Read the attached article on the effect of topical diclofenac on the symptoms of primary osteoarthritis of the knee by Bookman AAM, et al, and answer the following question:


Are the results of this study valid? (you may use the relevant part of the attached worksheet).


Q2.       Calculate the following with the reference to provided data on the use of Sertraline among patients with major depressive disorder.


a.           Absolute benefit increase.


b.           The number needed to treat to achieve this benefit.







Student’s Name: _______________________________ Number: _______________


Q2.    A randomized double-blind placebo-controlled trial was carried out to answer the following question:


          In children and adolescents with major depressive disorder (MDD), is sertraline more effective than placebo for reducing the severity of patients’ depressive symptoms?


Patients:       376 children and adolescents (age range 6-17 yrs, 51% girls) who met criteria from MDD according to the DSM-1V and Kiddie Schedule for Affective Disorders and Schizophrenia for School Age Children.


Interventions: Tablets of sertraline 50-200 mg/d (n=189) or placebo (n=187)

                     for 10 weeks.


Outcome:      > 40% decrease in depression score.




Sertraline V placebo in major depressive disorder at 10 weeks.





Patients with

> 40% decrease in depression score








A.   Rate of benefit increase (ABI).











B.    The number needed to treat to achieve this benefit.































































































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