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Molecular Genetics

BCH 550 

 (3+0) credit-hours

Time

Saturday 8:30 - 11:00

Monday  10:30 - 12:00

 Class Room  B:
 

  

 

 

The course is divided into 9 modules(3 hours each) which in turn are grouped into three sessions. A session will be allocated to certain instructor. Each instructor is asked to discuss with students one review article and a minimum of one research paper during his/her session

   Mark distributions. Each instructor has 100 marks ×3 =300, the final marks of instructors divided by factor (3). The letter grade for the course will be based on the results of one exam (60%). In addition (20%) for one presented research that is now based on research paper (and/or review article), the evaluation process depends on the assigned staff member. The last (20%)evaluation of an original research proposal written by the student in collaboration with the course instructor that is composed of 5-10 pages and includes: Title (suggested by the staff member), Literature Review, Aims(S), Methodology, Expected Outcome and References. Evaluation of this proposal will be totally by the assigned staff member.               

 

Module

Topics

1

Elements of DNA:

genes, pseudo-genes transposable elements, repetitive DNA, etc. Eukaryotic and prokaryotic  genome; Fundamental features of eukaryotic  and prokaryotic genes.

2

Gene interaction:

from genes to phenotypes, diagnostic test for alleles, interactions between the alleles of one gene.

3

DNA recombination, rearrangements:

Independent Assortment, Crossing-Over, Linkage Maps, Mitotic Crossing-Over, The Mechanism of Crossing-Over , etc

4

DNA replication:

the cell cycle; control and defects, apoptosis, DNA repair: mechanisms, methods to study DNA repair, syndromes.

5

Chromosome mutations:

introduction, changes in chromosome number, chromosomal rearrangements, the overall incidence of human chromosome mutations and evolution of the genome

6

Cytogenetics:

understanding the disease progression process, classical and molecular cytogenetic methods, chromosome segregation, the abnormalities in clinical syndromes and cancer

7

Transcription:

machinery and regulation (activators and repressors, histone modification, methylation). Epigenetic modification of the genome. Control of gene expression.  RNA interference as a mechanism for control of gene expression, splicing and connections with human diseases.

8

Translation:

mechanisms, regulation, post-translational modifications.

9

Bioinformatics

 

 Lectures (2nd Semester 1430/1431)

 
 

 Lectures BCH550

 
  
  
  
Student presentation Amani.pptStudent presentation Amaniد. جيهان جاويش الحسيني
student presentation 3.pptxstudent presentation 3د. جيهان جاويش الحسيني
Student presentation 2.pptStudent presentation 2د. جيهان جاويش الحسيني
student presentation 1.pptxstudent presentation 1د. جيهان جاويش الحسيني
Student Topic 1.pdfStudent Topic 1د. جيهان جاويش الحسيني
Student presentation 1.pptStudent presentation 1د. جيهان جاويش الحسيني
Student Topic 2.pdfStudent Topic 2د. جيهان جاويش الحسيني
Student Genetic recombination.docStudent Genetic recombinationد. جيهان جاويش الحسيني
Transposons.pptxTransposonsد. جيهان جاويش الحسيني
 

 Research Papers

 
 

 Review Articles

 
 

 Articles Within Chromosomes and Cytogenetics