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تحميل الدليل التدريبي

أسئلة شائعة


 

Course Syllabus

 

I- Course Identification and General Information

 

Institution

King Saud University, College of Pharmacy

Department

Pharmacognosy

Course title and code

 Pharmacognosy II  (322 PHG)

Credit hours

3 hrs/week (2 +1)

Program in which the course is offered

 

Bachelor degree of pharmaceutical science

Name of faculty member responsible for the course

 

Dr. Wafaa Hassan

Dr. Hanan Al-Youssef

Level at which this course is offered

Level 6

Pre-requisites for this course

 

 251 PHG

 

II- Objectives:  

The main learning outcomes for students enrolled in the course:

1-     Mention the plant origins of medicinally active alkaloids, glycosides and mention the plant origins of some toxic, hepatotoxic plants and drugs of obtuse.

2-     Describe the general methods of extraction and purification of alkaloids and glycoside

3-     Illustrate the qualitative and quantitative methods of assay of selected alkaloids and glycosides.

4-     Describe the pharmacological uses with some of the already marketed alkaloids and glycosides pharmaceutical products.

5-     Describe the toxic effects, as well as methods of treatment of some toxic plants

6-      Mention the effects of  drugs of abuse as well as some  hepatotoxic drugs and toxic mushrooms.

7-     Know the marine origins, pharmacological action, uses as well as clinical trial of some pharmacologically active marine natural products.

 

III-  Course Description  

 

Theoretical Course

Topic

No of

Weeks

Contact hours

Activity

Degree

Toxic plants,

 phytotoxins chemistry, toxic plants containing glycosides(cyanogenic, thioglycosides, cardiac, saponin, anthraquinone glycosides), toxic symptoms and methods of treatment

1/2

1

 

 

Toxic plants containing different classes of alkaloids, hepatotoxic plants

1/2

1

 

 

Drugs of abuse, toxic mushrooms

1/2

1

 

 

Alkaloids:

Definition, occurrence, chemistry, methods of isolation and, evaluation and medicinal uses, classification and nomenclature.

1

2

 

 

Non heterocyclic and heterocyclic alkaloids,

Tropolone, Ephedra, Khat, capsicum, mescaline, amanita alkaloids, tobacco,  lobelia alkaloids

1/2

1

 

 

Pepper, pomegranate, conium, trigonelline, cinchona,

1/2

1

 

 

Ipecaquanha, hydrastis, curare, opium alkaloids

1/2

1

 

 

Tropane alkaloids,  coca alkaloids

1/2

1

 

 

Xanthine alkaloids,  Indole alkaloids

Nux vomica,

1/2

1

 

 

Calabar beans, vinca, rauwolfia alkaloids,,

1/2

1

 

 

Ergot alkaloids, steroidal alkaloids, imidazole and terpenoid alkaloids

1/2

1

 

 

Marine derived drugs

Biomedical potential of marine natural products

1/2

1

 

 

Biologically active substances from marine sponges

1/2

1

 

 

Microalgae as drug source

1/2

1

 

 

Glycosides:

Definition, classification, methods of isolation and evaluation

1/2

1

homework

 

Cardiac glycosides

1/2

1

homework

 

Anthracene glycosides

1/2

1

homework

 

Flavonoidal glycosides

1/2

1

homework

 

Saponin glycosides

1/2

1

homework

 

Miscellaneous glycosides and related compounds

Glucosinolate, cyanogenic glycosides

Furocoumarines and furanochromes e.g. xanthotoxin and khellin

1

2

homework

 

 

Herb- drug interaction

3

6

Group discussion

 

Total Theoretical course

14

28

 

 

Practical Course

Topic

No of

Weeks

Contact hours

Activity

Degree

Assay of nicotine

1

3

 

 

Qualitative identification of glycoside

1

3

 

 

Assay of senna

1

3

 

 

Assay of cardiac glycosides

1

3

 

 

UV spectrum of flavonoids

1

3

 

 

Qualitative identification of alkaloids

1

3

 

 

Qualitative identification of alkaloids

1

3

 

 

Exam. Unknown glycoside +alkaloid+ quiz

1

3

 

 

Assay of morphine

1

3

 

 

Assay of reserpine

1

3

 

 

Assay of tropane alkaloids

1

3

 

 

Exam assay + quiz

1

3

 

 

Herbal – drug interaction

2

6

 

 

Total Practical course

14

 

 

 

 

IV- Learning Outcomes (Knowledge and skills):

 

1-Carry out separation, qualitative and quantitative determination of alkaloids and glycosides

 

2- Mention some alkaloids as start for semi-synthetic products

 

3- Discuss example for medicinally valuable marine natural products

 

4- Know the signs of toxicity and methods of treatment of toxicity of the described toxic plants.

5- Discuss the side effects and dangerous of drugs of abuse.

 

6- Debate chemical constituents of drugs containing glycosides.

7- Estimate the botanical source of these glycosides.

8- Assess the medicinal important of glycosides.

9- Determine the adverse effects and toxicity of glycosides.

10- Interpretation the possibility of the herb-drug interaction in-vivo.

11- specify the mechanism of action.

12- Evaluate the potential hazard of herb-drug interaction.

13 - Recommendation and advisement.

 

 IV- Schedule of Assessment Tasks for Students during the Semester:

 

Assessment

Assessment task

Date

Degree

1

 

First midterm exam

18\4\1430

12-1 PM 

2

 

Practical exam

9\5\1430

 10-1 am

3

 

Quiz

9\5\1430

10-1 am

4

 

Second Midterm

 

 

5

 

Practical exam

 

 

6

 

Quiz

 

 

7

 

Practical reports

 

 

8

Presentation

Group discussion

 Per week

 

9

Homework

Per day

 

            10

 

Final exam

 

 

 

 

VI- Student Support:

 

Office hours (Dr. Wafaa Hassan)

 

Day

Hour

Saturday

9-11

Sunday

8-10

Monday

-

Tuesday

8-10

Wednesday

-

 

                                                          Office hours (Dr. Hanan Al-Youssef)

 

Day

Hour

Saturday

------------

Sunday

11-1

Monday

--------

Tuesday

11-1

Wednesday

11-1

 
VII- Learning Resources

 

Required Text(s)

1-      Pharmacognosy 15thedition, Trease & Evans, (1996).

 

Essential References

1-      Pharmacognosy 15thedition, Trease & Evans, (1996).

2-      Drugs from the Sea, N. Fusetani, (2000).

3-      Natural product chemistry, Kurt, B.G. Torssel (1997)

4-      Alkaloids, chemical and biological perspectives, vol. 9, 10, S. William Pelletier (1995, 1996 respectively)

5-      The chemistry of natural products 2nd Ed. R.H. Thomson (1993).

6-      Pharmacognosy and pharmacobiotechnology, J.E. Robbers et.al (1996).

Recommended Books and Reference Material (Journals, Reports, ….)

Fitotherapia, Die Phrmazie, phytochemistry, Journal of natural products, Planta medica

Electronic Materials, Web Sites, …..

Scincedirect.com

Chemvillage.org.com

Kasct.com

Silverplatter.com

Other learning material such as computer-based programs/CD, professional standards/regulations:

 

 

 

Course Coordinator: Dr. Hanan Al-Youssef & Wafaa Hassan

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