King Saud University
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تحميل الدليل التدريبي

أسئلة شائعة



Course contents:


I- applications of modern NMR techniques:

1- spectral editing by the APT experiment

Basic principle, interpretation, applications in the identification of functional groups of terpenoids, steroids and cannabinoids.

2- homonuclear correlation techniques cosy, inadequate, noesy, basic principle interpretation, applications in the structure elucidation of selected examples of antibiotics, complex alkaloids and macrocyclic lactones.

3- polarization transfer experiments

INEPT, DEPT, DEPTGL, basic principles, interpretation, applications in the characterization of terpens, steroids, carotenoids and vitamins

4- heteronuclear shift correlation techniques, HMQC, HMBC, TOCSY, principle interpretation, applications in the structure elucidation and mechanism of action of selected examples of antibiotics, carbohydrates and sesquiterpenes.


II- Chemical and spectroscopic techniques used for stereochemical assignments.

1-      chemical degradation as a means of determining absolute stereochemistry literature examples from the fields of alkaloids and carbohydrates.

2-      Optical rotatory dispersion (ORD) and CD.

3-      Application of Horeaus and the benzoate rule for the determination of the absolute stereochemistry of terpenes.


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