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تحميل الدليل التدريبي

أسئلة شائعة


 

Camptothecin 

Introduction:    

 

Naturally Occuring Antitumor Agents:

 

     The plant kingdom is one of the attractive sources of novel anti-tumor compounds such as camptothecin (CPT) (1), baccharin, taxol, maytansine, vinblastine, vincristine and many others. However, the concentrations of these active compounds in plants are generally low (Table 1). In addition, the growth rate of plants is normally slow and the accumulation pattern of these compounds is highly susceptible to geographical or environmental conditions. Therefore, it is not an easy task to economically produce these compounds by mere extraction from intact plants1.

 

 

Table 1: Anti-tumor compounds isolated from higher plants and their concentration1.

 

 

Anti-tumor

Compound

 

 

Camptothecin

 

Baccharin

 

Maytansine

 

Taxol

 

Vinblastine

Vincristine

 

Plant yield in    (dry wt.%)

 

 

5.0x10-3

 

 

2.0x10-2

 

 

2.0x10-5

 

 

5.0x10-1

 

 

5.0x10-3

 

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