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تحميل الدليل التدريبي

أسئلة شائعة


 

Supported by Research Center
College of Science

 

1- Adipocytokine profile in metabolic syndrome as defined by various criteria (2005-2007)

Omar S.Al-Attas Ph.D1;Nasser M. Al-Dagrhi Ph.D2 Khalid Al-Rubeaan MD3

1,2 College of Science Department of Biochemstry, King Saud University

Riyadh 11451, PO Box 2455 Kingdom of Saudi Arabia; 3King Abdul-aziz University Hospital Riyadh, KSA

Tel no. 0096614675939 Fax no. 0096614675931

E-mail: omrattas@ksu.edu.sa 

Background

Studies on assessing predictive powers of the different definitions of metabolic syndrome to clinical conditions were identified. Its relation to adipocytokines and inflammatory markers however has not been documented. Such markers are potential therapeutic targets for both diabetes and cardiovascular disease. This study aims to correlate the definitions of metabolic syndrome to pathological levels of leptin, adiponectin, resistin, TNF-@, and CRP among type 2 diabetic patients.

Subjects and Methods

305 (160 males and 145 females) type2 diabetic Saudis participated in this prospective and cross-sectional study. Anthropometrics were measured and blood parameters by routine lab procedures. Leptin, adiponectin, resistin, TNF-@ and CRP were analyzed using enzyme-linked immunosorbent assays (ELISA). Each participant was screened for metabolic syndrome based on definitions of WHO, NCEP-ATPIII and IDF.

Results

IDF criteria identified most patients [190 cases (62.3%)] in both males [197 (67.9%)] and females [83 (57.2%)]. In males, leptin and adiponectin were higher [1.97 (0.51-7.57); 2.49 (0.3-21.76) respectively] using the criteria set by NCEP-ATPIII. Resistin and CRP however were most elevated [1.28 (0.32-5.04); 2.04 (0.46-9.04) respectively] using the WHO definition. In females, IDF-defined has the strongest association in 3 of 4 parameters analyzed compared to other criteria: leptin [2.09 (0.14-30.71)]; adiponectin [6.00 (0.47-76.17)] and CRP [3.07 (0.21-45.10)]. The risk of hyperresistinemia on the other hand was highest using NCEP-ATPIII [0.53 (0.20-1.37)].

Conclusion

Gender differences exist in assessing risk of various metabolic abnormalities in relation to different metabolic syndrome criteria. Proper selection of definition is essential for more accurate health care strategies and intervention.

 

2- Correlation of serum adipocytokines to family history of diabetes mellitus and smoking history in non-diabetic subjects

(2005-2007)

Nasser M. Al-Daghri1*, Omar S. Al-Attas1, Mohammad Al-Onazi 1, Khalid Al-Rubeaan2, Hussein Al-Najjar1

Address: 1* College of Science Biochemistry Department, King Saud University Riyadh, KSA, 2Diabetes Center, King Abdul-Aziz University Hospital, Riyadh, KSA

Abstract 

Background

The controversial roles played by major adipocytokines such as resistin, leptin and adiponectin in obesity and insulin resistance were extensively studied. This paper aims to explore for the first time the possible effect of a family history of diabetes mellitus and smoking on non-diabetic individuals and associations to other metabolic parameters.

Results

In females there were significantly lower adiponectin levels among those with family history compared to those without (p 0.045); BMI and family history of diabetes contributed significantly to adiponectin levels with 43.7% variance (r2 19.1; p 0.018). In males there was a near-significant decrease in resistin levels of smokers compared to non-smokers (p 0.05). Linear regression showed a correlation between log resistin and LDL, and ApoA1 in all subjects (p-values 007, 0.0009 and R2 0.12, 0.08 respectively).

 

Conclusion

This study showed for the first time that among the three adipocytokines, adiponectin was the only one to exhibit variations in females alone with regard to a family history of diabetes; the rest were independent of smoking. This study supports the view that adiponectin is a risk marker for diabetes.

 

 

 

4- Fasting homocysteine levels in adults with type 1 diabetes mellitus link with cardiovascular complications and other risk enhancers. (2006)

Abstract

High Homocysteine levels in the blood have recently been recognized as an independent risk factor for the development of cardiovascular disease. In diabetes mellitus cardiovascular disease accounts for most diabetes associated mortality. Conflicting reports appear in the literature correlating high homocysteine levels with diabetes mellitus and subsequently it’s associated cardiovascular complication. Homocysteine levels seem to be related to ethnicity and susceptibility to genetic polymorphisms of Methylenetetrahydrofolate reductase gene mutations. It is also related to diet, age and the development of nephropathy in diabetes mellitus. Recent studies in the Saudi diabetic population found a correlation between plasma homocysteine levels and type II diabetes mellitus without the usual correlation to cardiovascular disease.

 

Our study sets out to assess whether homocysteine is increased in type 1 diabetes mellitus, which is characterized by a higher prevalence of cardiovascular complications, and whether there exist a correlation between homocysteine, type 1 diabetes mellitus and cardiovascular disease in a cohort of Type 1 Diabetics of this population. The result of this research will add valuable information to the health literature available to physicians and experts who manage patients with both diabetes mellitus and cardiovascular disease complication in this population.

 

مستوى الهيموسيستين في حاله الجوع لدى البالغين المصابين بالنوع الأول:- بداء السكري – العلاقة مع مضاعفات أمراض القلب المخاطر المعززة الأخرى.(2006م)

 

يعتبر ارتفاع مستوى الهيموسيستين في الدم أحد أهم العوامل المسببة لأمراض القلب المسببة للوفاة خاصة عند المصابين بداء السكري. هناك دراسات توضح أن ارتفاع مستوى الهيموسيستين لدى مرضى السكري له علاقة بمضاعفات أمراض القلب. هناك علاقة أيضا بين مستوى الهيموسيستين وكلا من: العرق وحساسية الهيموسيستين إلى تعدد الأشكال الجينية والتغيرات لجين (ميثايلين تتراهيدروفولات ردكتاز) إضافة إلى الحمية والعمر وتطور الإصابة بالكلى عند مرضى السكري. دراسة حديثة لمرضى السكري السعوديين وجدت علاقة قوية بين الهيموسيستين وداء السكري من النوع الثاني وعلاقة ضعيفة بين الهيموسيستين وأمراض القلب.

في هذه الدراسة سنحدد هل الهيموسيستين يزداد عند مرضى السكري من النوع الأول – الذين هم أكثر عرضة للإصابة بمضاعفات أمراض القلب – وهل هناك علاقة بين الهيموسيستين لدى مرضى القلب المصابين بداء السكري من النوع الأول. نتائج هذا البحث ستضيف معلومات قيمة للأطباء والمهتمين في كيفية التعامل مع المرضى المصابون بداء السكري من النوع الأول و أمراض القلب

 

 

5- Effects of Cadmium Toxicity on the Activities of Lactate Dehydrogenase and Monoamine Oxidase in the lung of Adult Male Rats (2007)

 

تأثير سمية الكادميوم على مستوى نشاط الإنزيم المزيل لحامض اللبنيك وإنزيم أحادي أكسيد الأمين وعلاقتهما بتراكم الجذور الحرة في رئة الجرد

 

                              

 

 

 

 
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