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تحميل الدليل التدريبي

أسئلة شائعة


 

CURRICULUM VITAE

Majed Saleh Abdullah Alokail

 

Nationality:                Saudi Arabia.

e-Mail Address:         msalokail@yahoo.com.

Current Position:        Associate Professor

Present Address:       Department of Biochemistry, College of Science #5,

King Saud University, P.O. Box 2455, Riyadh 11451

Tel. ++9661-467-5943, Fax. ++9661-467-5931

Qualifications:

1-  BSc., Biochemistry, King Saud University in Riyadh, Saudi Arabia.

2-  MSc., Biochemistry, King Saudi University in Riyadh, Saudi  Arabia.

3- High diploma in Insulin Gene Therapy, Gunma University, Maebashi, Japan

4- Ph.D in Molecular Pharmacology at University of Southampton, UK.

5- Canadian Breast Cancer Society for post-doctoral fellowship.

 

Research Interest:

1-     Cancer Molecular Biology

2-     Molecular Pharmacology

3-     Apoptosis and Molecular Signalling

4-     Endocrinology

 

Membership of Scientific Associations:

American Diabetes Association                                               

American Bone and Mineral Research                                   

American Association for Cancer Research                           

American Endocrine Society

British Endocrine Society

Federation of American Societies for Experimental Biology 

 

Awards and Fellowships:

1-     Sabbatical leave at Cancer Science Center at University of Southampton, Southampton, UK and Endocrine Unit at Harvard Medical School, Boston, MA, USA between June 2005 and September 2006.

2-     AACR – AVON Breast Cancer Foundation Award for a presented paper entitle " Induction of erbB1 and erB2 Receptors by PTHrP in Breast Cancer Cells" in the 96th Annual Meeting of American Cancer Research (AACR) in Los Angeles, CA.USA, 2005.

3-     British Airspace Summer Postdoctoral Fellowship on at Cancer Science Center at University of Southampton, Southampton, UK. June – September, 2005.

4-     Postdoctoral fellowship for summer visit to Southampton University June 16, 2004 until August 18, 2004.

5-     British Airspace Summer Postdoctoral Fellowship on 2002 at Cancer Science Center at University of Southampton, Southampton, UK. June 9, 2002 until September 7th  2002.

6-     British Airspace Summer Postdoctoral Fellowship on at Cancer Science Center at University of Southampton, Southampton, UK. June 11, 2003 until September 11th  2003.

7-     Postdoctoral fellowship for summer visit at Dept., of Pharmacology, University of Texas Medical Branch, Galveston, Texas. USA. From June 16, 2001 until August 31, 2001.

8-     Canadian Breast Cancer Society for post-doctoral fellowship in Department of Biochemistry and Molecular Biology at University of Manitoba, Winnipeg, Canada

9-     Japanese Government Scholarship (MONBUSHO) from March, 1991 to September,1992.

 

Research Grants:

 

1-     Research Grant from College of Science Research Centre. ''The relationship between obesity and breast cancer.''

2-     Research Grant from College of Science Research Centre. ''The relationship between obesity and prostate cancer.''

3-     Research Grant by College of Science Research Centre. ''The relationship between the expression of PTHrP receptor and EGF receptor in breast cancer cells.''

4-     Research Grant from King Abdulaziz City for Science and Technology (KACST). "Obesity causes in school children" For a period of one year.

5-     Research Grant from King Abdulaziz City for Science and Technology (KACST). "Effect of Parathyroid hormone-related peptide (PTHrP) in breast cancer MCF7 cells proliferation." For a period of one year.

6-     Research Grant from King Abdulaziz City for Science and Technology (KACST).The comparative effects of vitamin D and its analogs in prostate and breast cancer cells proliferation and the expression of parathyroid hormone-related peptide (PTHrP) in these cells. For a period of one year.

7-     Research Grant from SABEC."Effect of Polycyclic aromatic hydrocarbons in breast cancer genetic damage and tumor development.'' For a period of two years.

 

Collaboration insititues:

          1- Abdulaziz City for Science and Technology

          2- King Faisal Specialist Hospital and Research Center

          3- Southampton University

          4- University of TexasGalveston

 

Book publication.

Title of the chapter: Molecular Signaling of PTHrP in Tumor, MS Alokail. In Novel aspects of PTHrP physiopathology; Editors: C. Luparello,  Novapublishers, This book will release on the 17th of December 2007.

 

Research Papers:

O.S. Al-Attas and M.S. Alokail. Features of insulin receptor interaction in       placenta from normal, overt and poorly controlled gestational diabetic    patients. Molecular & Cellular Biochemistry. (Netherlands) 1991, 126: 135-142.

M.S. Alokail and O.S. Al-Attas. Histological changes in Placental        Syncytiotrophoblast of poorly controlled gestational diabetic patients.           Endocrine Journal.(Japan) 1994, 41(4), 355-360.

M.S. Alokail. Modefied Iodo-Gen method for peptide hormones iodination.    Journal of Saudi Chememical Society, 2002, 6:15-20.

M.S. Alokail. Potential regulation of PTH/PTHrP receptor expression in          choriocarcinoma JAR cell line. Saudi Medical Journal, 2004, 25: 615-         620.

M.S. Alokail and S.A. Alarifi. Histological changes in lung of Wistar albino rats            (Rattus norvegicus) after exposure to the Arabian incense (Genus Boswellia).         Annals of Saudi Medicine, 2004, 24: 217-219.

M.S. Alokail. PTHrP Gene Transfection Regulates Colon Cancer Cells           Proliferation. Portugal.Medimond International Proceedings. 2004,       1467-1471.

S.A. Alarifi M. Mubarak and M.S. Alokail. Ultrastructural changes of pneumocytes of rat exposed to Arabian incense (Bakhour). Saudi Medical        Journal. 2004 Nov;25(11):1689-93..

S.A. Alarifi, M. Mubarak, M.S. Alokail. Ultrastructure of the Pulmonary Alveolar        cells of rats exposed to Arabian mix incense (Ma'amoul). Journal of            Biological Sciences. In press. 4:6: 694-697, 2004.

M.S. Alokail and M. Alhasan. Thermo Stable Characteristics of Arabian Palm             Date (Phoenix Dactylifera L.) Peroxidase.Saudi Journal of Biological           Sciences. 2005: 12; 1; 25-31.

Alokail MS. Transient transfection of epidermal growth factor receptor gene into          MCF7 breast ductal carcinoma cell line. Cell Biochemistry and  Function.            2005;23(3):157-61.

Barnes, J.D., Arhel, N.J., Lee, S-S., Sharp, A., Alokail, M.S, Packham, G.,   Hague, A., Paraskeva, C and Williams, A.C. Nuclear BAG-1 expression          inhibits apoptosis in colorectal adenoma derived epithelial cells: Implications in colorectal tumour development. Apoptosis. 2005          Mar;10(2):301-11.

Alokail MS. Influence of parathyroid hormone-related peptide gene in colon    cancer cell line growth. Saudi Med J. 2005 May;26(5):714-717.

Al-Mansouri LJ, and Alokail MS. Molecular basis of breast cancer. Saudi      Med J. 2006 Jan;27(1):9-16.

Ahmed MH, Osman MM, and Alokail MS. Statins and breast cancer: a smoking gun or guilt by association? Expert Opinion Drug Safety. 2006 Sep;5(5):599-601.

Alokail MS and Peddie MJ. Characterisation of ligand binding to the   parathyroid hormone /parathyroid hormone-related peptide receptor in        MCF7 breast cancer cells and SaOS-2 osteosarcoma cells. Cell           Biochemistry and  Function. 2007;25: 139-147.

Alokail MS. Comparative effects of vitamin D and EB1089 analoge in mRNA             expression of parathyroid hormone-related peptide in prostate and breast   cancer cells. Endocrine Abstracts. 2007: 13; P120.

Alokail MS. Molecular Signalling of PTHrP in Breast Cancer MCF7 Cells       Transfected with EGFR and erbB2 Receptor Genes. Submitted for publication.

Alokail MS. comparative effects of vitamin D and EB1089 analoge in mRNA expression of parathyroid hormone-related peptide in prostate and breast   cancer cell lines. Submitted for publication.

Alokail MS. Cobalt Chloride (CoCl2), a Chemical Inducer of Hypoxia-Inducible         Factor-1 gene and Hypoxia Apoptotic Cell Death in many Cancer Cell Lines.          Submitted for publication.

 

Poster or Oral Presentation in International Conferences:

M.S. Alokail and OS. Al-Attas (1990) Characterization of insulin-receptor interaction in Saudi diabetic pregnancy. On Fourth Kuwait International Medical Science Conference: Diabetes Mellitus. March 4-8, Univeristy of Kuwait Faculty of Medicine, Kuwait.

M.S. Alokail and OS. Al-Attas. (1992) Biochemical, Histological and Histochemical changes in diabetic placenta. On first international union of biochemistry and molecular biology (IUBMB): Biochemistry and diseases. June 1-6, Nagoya Congress Center, Japan.

M.S. Alokail and MJ. Peddie (1997) Parathyroid hormone-related peptide (PTHrP) as an autocrine growth factor in breast cancer MCF7 cells. in Growth Factor Group symposium, November 26TH, St.Thomas's Hospital in London.

MS. Alokail and MJ. Peddie. (1998) The role of Epidermal Growth Factor. Estradiol and 1,25 Dihydroxycholecalciferol in Production of PTHrP from breast cancer MCF7 Cells.  Journal of Endocrinology. 156: P113.

M.S. Alokail and MJ. Peddie 1998).Characterisation of parathyroid hormone / parathyroid hormone-related peptide receptors in the breast cancer MCF7 cells. In 80TH annual meeting of American Endocrine Society meeting. P3-143, June 24-27, 1998 in New Orleans, USA

M.S. Alokail and M.J. Peddie (1998). Effect of parathyroid hormone (1-34) and parathyroid hormone-related peptide (1-34) on epidermal growth factor receptor expression in breast cancer MCF7 cells. In 80TH annual meeting of American Endocrine Society meeting. P3-323, June 24-27, 1998 in New Orleans, USA

M.S. Alokail and M.J. Peddie (1998). Characterization of the PTHrP specific receptor in MCF-7 breast cancer cells.  Journal of Endocrinology. 159: P42

M.S. Alokail and JM. Peddie (1999). Regulation of PTH/PTHrP receptor expression in MCF-7 breast cancer and SaOS-2 osteosarcoma cells by dexamethasone, 1,25 DHCC, EGF, E2, and PTHrP-1-34.  Journal of Endocrinology. 160: P183

M.S. Alokail and MJ. Peddie (1999). Effect of EGF, estradiol, 1,25 dihydroxycholicalciferol, and dexamethasone on PTH/PTHrP receptor affinity in MCF-7 breast cancer and SaOS-2 osteosarcoma cells.  Journal of Endocrinology. 160: P184

M.S. Alokail and MJ. Peddie (1999). Effect of Trp23-PTHrP-1-36 and Ile5-Trp23-PTHrP-1-36 on displacement of 125I-PTHrP-1-34 on breast cancer MCF7 cells and osteosarcoma SaOS-2 cells. In 81st annual meeting of American Endocrine Society, P-118, June 12-15, 1999, San Diego, CA, USA

M.S. Alokail and MJ. Peddie (2001). Investigation of PTH and PTHrP interactions to the PTH/PTHrP receptor in the choriocarcinoma JAR cell line. In 83rd annual meeting of American Endocrine Society, P2-635, June 20-23, Denver, Co, USA

M.S. Alokail (2002). Regulation of  choriocarcinoma JAR cell line  proliferation and  PTH/PTHrP receptor expression with EGF, E2, DEX or 1,25 DHCC. In 84th annual meeting of American Endocrine Society (Genome on Endocrinology), P2-230, June 19-22, San Francisco, CA, USA.

M.S. Alokail (2003) Influence of parathyroid hormone-related peptide gene on proliferation of human colonic cancer cells. The 94th Annual Meeting of American Cancer Research in Toronto, Ontario, Canada

MS. Alokail. Application of insulin gene therapy in non-endocrine cell line, COS-7. In 6th Saudi Pharmaceutical international conference. 6-9, October, 2003, Riyadh, Saudi Arabia

M.S. Alokail. Resistin hormone and type II diabetes mellitus. In 6th Saudi Pharmaceutical international conference. 6-9, October, 2003, Riyadh, Saudi Arabia

M.S. Alokail. New application for iodo-gen iodination with single or multi tyrosine residues in peptide hormones. In the 2nd International conference on chemistry and its applications. 6-9 of December, 2003, Doha, Qatar.

MS. Alokail. Parathyroid hormone-related peptide gene transfer and colon cancer cell proliferation. In the 23rd Joint Meeting of the British Endocrine Societies. 22nd-24th March 2004 in Brighton, UK

M.S. Alokail. Parathyroid hormone-related peptide stimulates signal transduction  pathway of ErbB1 and ErbB2 receptors in breast cancer cells.  The 86th Annual Meeting of The American Endocrine Society, P3-34, 16-19, June, 2004, New Orleans, USA.

M.S. Alokail (2005) Induction of erbB1 and erB2 Receptors by PTHrP in Breast Cancer Cells. The 96th Annual Meeting of American Cancer Research (AACR) in Los Angeles, CA.USA, P5780, page 383.

M.S. Alokail. PTHrP Induced the Signalling of Breast Cancer MCF7 Cells Transfected with EGFR and erbB2 Receptor Genes. Meeting of The American Endocrine Society,June, 2006: P1-376.

O.M. Aboulwafa, KM. Youssef, A.M. Al-Okbeid and M.S. Alokail. Modified Estrogens: Synthesis of alkylamino- and alkylthioacetylamino estrone derivatives as anticancer agents. The 7th International Saudi Pharmaceutical Conference. March, 2007, Riyadh. KSA

O.M. Aboulwafa, m.s. Al-mutairi, KM. Youssef, H.I. Al-Subbagh, O.A. Al-Deeb, A.J. Fatani and M.S. Alokail. Synthesis of some 2- and 4-peptidylestrone derivatives of potential therapeutic activity. The 7th International Saudi Pharmaceutical Conference. March, 2007, Riyadh. KSA

      Alokail MS. Comparative effects of vitamin D and EB1089 analoge in mRNA    

       expression of parathyroid hormone-related peptide in prostate and breast cancer 

       cells. British endocrine society meeting (BES07). March 5th to March    8th, 2007.

      Birmingham, UK.

 

Papers in Arabic Language:

1-     ماجد بن صالح العقيل. التحالفات البحثية وأهميتها الاقتصادية في المملكة العربية السعودية. مؤتمر الشراكة بين الجامعات والقطاع الخاص في البحث والتطوير. 1-3 ربيع الاول 1426هـ الموافق 10-12 أبريل 2005م  صفحة 123 –144.

2-     ماجد بن صالح العقيل. الاهمية الإقتصادية في إسترتيجيات تكوين التكتلات البحثية في دول مجلس التعاون الخليجي. تحديات التنمية الإقتصادية لدول مجلس التعاون الخليجي. معهد الكويت للأبحاث العلمية. مارس 2006 صفحة 39 – 59.

3-     ماجد بن صالح العقيل. التحالفات البحثية والواقع العربي. الثقافية. العدد 63 ربيع الآخر، جمادى الاولى 1427هـ / مايو، يونيو 2006م صفحة 22 – 25.

  

 
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