بسم الله الرحمن الرحيم
نموذج إمتحان نهائي لمادة الكيمياء الحيوية للمسرطنات
Please mark the correct statements with (T) and the incorrect one with (X):
1- In development of colon cancer, the benign formed after the polyp formation.
2- Direct-acting carcinogens chemically modify certain nucleotides by reacting
with nitrogen and oxygen atoms in DNA.
3- Quinolines found in an industrial products and they found in tobacco smoke.
4- The malignant tumor site contains invasive tumor cells and normalepithelial
5- The aromatic or heterocyclic amines metabolism can lead to ring epoxy
derivatives by reducing the hydrodiols ar rearrange the diphenols.
6- The hyperactive mutant protein produces from altered coding sequence on the
7- In animals, activation of indirect-acting carcinogens like insecticides often is
carried out by lung enzymes.
8- Aromatic amines are analogs of aniline and they activated to nitrenium (N+) ion.
9- The class II adenoma is the last stage before malignancy development.
10-The epigenetic carcinogens have direct interaction with genetic materials.
11- Benzo(a)pyrene activated by epoxide hydralase in human cells.
12- Because they easily detoxified, the polycyclic arylamines are not
13- Major classes of cancers derived from epithelial cells because they are surface
cells and they suffer exposure to dangerous chemicals and harmfull radiation
14- The heterocyclic amines consist from single or multiple ring systems with
exocyclic amino group.
15- Many carcinogens are or can be biotransformed to electrophiles that react
covalently with DNA.
16- Cocarcinogens are agents which have strong carcinogenicity effect.
17- Tumor known when regulated cells have descendants that inherit the
propensity to proliferate without responding regulation.
18- The undifferentiated cancer is the last step in neoplastic development.
19- Azo compounds are synthetic chemicals found in nature including 4
20- The halo ethers are halogens and they do not activated by electron transfer.
21- Benign tumor referring to a tumor containing cells that closely similar to the
22- Cis-Platinum is complex chelating divalent platinum with chloride anion and
three amino groups.
23- Anesthetic gases like halothane, nitrous oxide and metofane have embryotoxic
24- Indirect-acting carcinogens acts as potent cancer inducers only after conversion
to ultimate carcinogens.
25-Under an aqueous condition, Nitrosamides can be hydrolytic decomposition.
Q2; Each question has four multiple choices. Please mark the correct and the incorrect one:
1- The lumen of colon in malignant tumor development contains of:
A- Blood vessel.
B- Invasive tumor cells.
C- The polyp.
D- Basal lamina.
2- STEVIA is:
C- Powdered dietary.
3- N-acetyltransferase system found in;
B- Heterocyclic amines
4- Cancer ;
A- Caused by a mutation in somatic cells.
B- Caused by an accumulation of 3 to 20 mutations.
C- Caused by a mutation in both somatic and germ cells.
D- Caused by a single mutation.
5- The enzymes shown below are activated or deactivated many chemical
Carcinogens in cellular compartments:
A- Epoxide hydrolase. .
C- Glucuronation enzyme.
6- Many of indirect-acting carcinogens are;
A- fat-soluble compounds
B- accumulate in fat cells and lipid membranes.
C- Excreted from the body as they are
D- Converted to water-soluble derivatives
7- In malignancy:
A- Refer to tumor cells that invade surrounding normal tissue.
B- The malignant cells express special proteins.
C- Cells divided more rapid.
D- The cells start to died fast.
8- The DNA adducts effect by;
A- Activation dependent compounds
B- Promoter compounds
C- Inorganic compounds
D- Cytotoxic compounds
9- The aromatic structure carcinogens;
A- Nitrogen mustard
B- Methyl nitrosourea
C- Dimethyl sulfate
10- The metastasis:
A- Known as spread of tumor cells and establishment of secondary
area of growth.
B- All malignant cells have an ability to metastasized.
C- Charachterized from benign ones by invasiveness and spread.
D- Is the last step in tumor development.
11- The Acesulfame-K:
A- Is artificial color.
B- Found in chewing gum.
C- Found in gelatine.
D- Occur in nature.
12- The carcinogens promotion stage includes:
A- Activated carcinogens binds to DNA.
B- Alteration in DNA structure.
C- Stimulation of DNA replication
D- Transformed cell formation.
13- Most of mutagenic chemicals found in the Salmonella Typhimurium TA98 are;
14- Malignant tumors classes:
A- Sarcomas derived from endoderm.
B- Carcinomas derived from endoderm and mesoderm.
C- All malignant tumors are solid masses.
D- Leukemias is a class of ectoderm.
A- Form reactive carbonium (C+) ions.
B- Contaminates of cereal grains and peanuts.
C- Analogs of aniline.
D- Formed by reaction of nitrite with amines at low pH.
16- The epigenetic carcinogens is;
C- Activation dependent
D- Peroxisome proliferators
17- Yellow 6 is artificial coloring found in:
A- Cherries in fruit cocktail.
B- Baked goods. C- Pet food.
18- Genes and cancer:
A- Proto-oncogenes are mutant genes that promotes cancer.
B- Tumor-suppressor genes work as anti-proto-oncogene.
C- Proto-oncogenes produce from mutated an oncogene.
D- Both oncogenes and proto-oncogenes prevent unwanted cell
19- Carcinogene Stages:
A- In the initiation stage leads to deactivation and excretion.
B- In the initiation stage covalent binding to DNA leads to error and
C- In promotion stage start with derepression of chromosomal
D- In promotion stage transformed cells leads to immune surveillance.
A- Formed by combustion of carbonaceous materials.
B- Activated by epoxidation.
C- Have promoter activity.
D- Cause skin and lung cancer.
A- Activation independent carcinogens.
B- Inorganic carcinogens.
C- Hormone modifying carcinogens.
D- Activation dependent carcinogens.
22- The plastics is;
A- DNA reactive carcinogens.
B- Epigenetic carcinogens.
C- Solid state carcinogens.
23- Nitroso compounds ;
A- Derived from primary amines or amides.
B- Have carcinogenic effects.
C- Cause alkylation of DNA in liver cells.
D- Do not found in antibiotic drugs.